Navigation Links
Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients
Date:12/8/2008

SAN FRANCISCO, Dec. 8 /PRNewswire-FirstCall/ -- Amgen Inc. (Nasdaq: AMGN) today released updated results from the ongoing, open-label extension study of the long-term safety and efficacy of Nplate(TM) (romiplostim) in adult patients with chronic immune thrombocytopenic purpura (ITP). Chronic ITP is a chronic and serious autoimmune disorder characterized by lower than expected platelet counts in the blood, sometimes leading to serious bleeding events. The results were presented today as an oral presentation at the 50th Annual Meeting of the American Society of Hematology (ASH Abstract # 402). Results from a study of Nplate in myelodysplastic syndromes (MDS) also were presented.

"These data show Nplate increased platelet counts in most patients for most of the time, and clinically relevant bleeding was reduced over time," said David J. Kuter, M.D., Chief of Hematology, Massachusetts General Hospital, Boston. "This is significant because Nplate can be a long-term treatment for adult chronic ITP patients, who are at risk of serious bleeding events if their platelet counts drop to less than 30,000 per microliter. These patients have had limited availability to long term treatment options."

These study results showed that overall 74 percent of patients (160/215) achieved a platelet response defined as a platelet count of 50,000 platelets per microliter and doubling of the baseline platelet count (median:17,000 platelets per microliter). A platelet response was achieved by 30 percent (61/207) of patients after the first dose and by 47 percent (94/199) of patients after the third dose. The average treatment period was 76 weeks and the longest duration of treatment was 204 weeks.

Additional key findings from the Extension study show:

-- Platelet counts increased: Platelet counts of Nplate-treated pati
'/>"/>

SOURCE Amgen Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine technology :

1. GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP
2. Schering-Plough Unveils Top-Line Study Results for SAPHRIS(TM) (asenapine) Demonstrating Efficacy in Long-Term Schizophrenia Relapse Prevention
3. Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients
4. Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults
5. CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohns Disease Patients
6. Continuous Treatment With Abbotts HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment
7. Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain
8. Medivation Presents Positive New Data on Dimebons Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimers Disease
9. Precise Low-Dose Drug Monitoring Essential for Long-Term Kidney Transplant Success
10. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
11. Patients Own Infection-Fighting T Cells Put Late-Stage Melanoma Into Long-Term Remission - Without Chemotherapy or Radiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015 Oramed Pharmaceuticals Inc. ... pharmaceutical Company focused on the development of oral drug ... been screened in the Company,s Phase IIb trial of ... will be performed under the active Investigational New Drug ... Drug Administration (FDA). The Phase IIb study ...
(Date:6/30/2015)... , June 30, 2015  July 4 th ... of independence, and the spirit and people behind it. To ... has partnered with USA Medical Card, ... increase funding for programs that empower independence for our disabled ... and help more people afford their prescriptions. "Due ...
(Date:6/30/2015)... June 30, 2015  EnteroMedics Inc. (NASDAQ: ETRM ... neuroblocking technology to treat obesity, metabolic diseases, and other ... public offering  of 40,229,886 units. Each unit consists of ... A warrant to purchase one share of common stock, ... one share of common stock, at a purchase price ...
Breaking Medicine Technology:Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 3Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 3
... 3 Australian researchers have developed gene expression ... colorectal growths from non-cancerous controls. , , ... conference in Chicago, the preliminary findings are the ... Flinders University and Australian healthcare company, Clinical Genomics ...
... Day 3 And All Subsequent Study Visits - , ... Pharma Co., Ltd., (DSP) announced today that positive results from ... of patients with schizophrenia have been published in The ... placebo-controlled trial, involving 180 patients with acute schizophrenia, evaluated a ...
Cached Medicine Technology:Advance in Bowel Cancer Test Research 2Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 2Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 3Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 4
(Date:7/1/2015)... (PRWEB) , ... July 01, ... ... in the communities of southeast Alabama, southwest Georgia and the Florida Panhandle, ... TelmedIQ as its primary secure text messaging and clinical communications workflow solution ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... the legal medical cannabis space, created a web-based resource where legal cannabis ... Harvest Financial brings together visionary entrepreneurs and medical marijuana advocates looking to strategically ...
(Date:7/1/2015)... ... ... Effective June 9, 2015, the Radiology Business Management Association (RBMA) ... process has been in place since the RBMA was founded in 1968 with all ... succeeds Keith E. Chew, MHA, CMPE, as president. Ms. Taylor has been an RBMA ...
(Date:6/30/2015)... , ... July 01, 2015 , ... Carey Danis ... lawsuits being managed in a West Virginia federal court. The court document outlined ... trial date for the 26 cases.¹ , Carey Danis & Lowe is a personal ...
(Date:6/30/2015)... ... ... Down is a reputable source of authentic Kid Rock tickets at the DTE Energy ... road again this summer in what is one of the most affordable summer tours in ... this year at the XFINITY Theatre in Hartford, CT on June 24th and the blockbuster ...
Breaking Medicine News(10 mins):Health News:Southeast Alabama Community Health System Chooses TelmedIQ to Meet Secure Text Messaging Challenges for Healthcare 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 3Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 2Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 3Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 4Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 2Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 3Health News:Cheap Kid Rock Tickets at the DTE Energy Music Theatre in Clarkston: Ticket Down Has Slashed Prices On All Kid Rock Tickets at DTE in the Detroit Metro Area 2
... 2,000,000 Minnesotans have designated their wishes to donate,on their ... April 1, 2008 When,Minnesotans apply for or renew ... with the opportunity to check the,box designating themselves organ ... taken that important step and said yes to the,life-saving ...
... CA, April 1, 2008 Rap music has gone from ... substance abuse to one that often glorifies illegal drug use, ... genre covering nearly two decades. The study is published ... a peer reviewed scientific journal., Positive portrayals of drug use ...
... protein helps virus conceal itself from body,s defenses , , ... discovered how HIV -- the virus that causes AIDS -- ... body,s immune cells. , They explained that when a normal ... immune system responds and produces cells that quickly eliminate the ...
... With Melanin-Rich Skin Tones, SKILLMAN, N.J., April 1, 2008 ... skin tones between,the ages of 25 and 54 experience dry ... only skin concern for these women. Women with,richer skin tones ... due to the excess melanin in their skin that often ...
... NEW YORK, April 1 SpongeTech Delivery,Systems, Inc. ... Darryl,Strawberry Foundation are pleased to announce corporate involvement ... for the New,York Mets, I am excited about ... have been a great tool for children with,autism, ...
... April 1, 2008 Valensa International,introduced Crannose(TM) ... Natural Products Expo West Conference. This patent-pending,supplement, ... known benefits of cranberry with D-mannose, a ... Larch tree. The,product is available in bulk, ...
Cached Medicine News:Health News:Minnesotans Demonstrate Commitment to Organ and Tissue Donation 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 3Health News:Scientists Uncover How HIV Hides Inside Cells 2Health News:AMBI(R) Introduces SOFT & EVEN(TM) 2Health News:AMBI(R) Introduces SOFT & EVEN(TM) 3Health News:SpongeTech Delivery Systems, Inc. to Donate to The Darryl Strawberry Foundation!! 2Health News:Crannose(TM) Extra Strength Women's Health Formula Targets Urinary Tract Infections 2
Used for internal biliary drainage. Supplied sterile in peel-open packages. Intended for one-time use....
... Marker directly to the biopsy site helps ... performed. ,The MICROMARK® II Tissue Marker is ... for use with the MAMMOTOME Biopsy System. ... site after a biopsy with the MAMMOTOME ...
... wrap than VICRYL knitted mesh. Especially suitable ... contained. Predictable absorption. Polyglactin 910 has been ... ,VICRYL (polyglactin 910) woven mesh is prepared ... and lactide, derived respectively from glycolic and ...
Used for implantation to reinforce soft tissue. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: