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Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
Date:12/10/2007

Study Shows that Long-Term Soliris Therapy Continued to Be Associated with Reductions in Thrombosis and Improvements in Fatigue, Quality of Life, and

Anemia in PNH Patients Data Presented at the American Society of Hematology (ASH) Annual Meeting

Posters: 897-III & 891-III

CHESHIRE, Conn., Dec. 10 /PRNewswire-FirstCall/ -- Patients with a rare blood disorder called paroxysmal nocturnal hemoglobinuria (PNH) were found to be six times more likely than the general public to have chronic kidney disease (CKD), as shown in an ongoing open-label clinical study of patients with PNH. Additionally, results from clinical studies in patients with PNH presented today at the American Society of Hematology (ASH) Meeting in Atlanta indicated that long-term treatment with Soliris(R) (eculizumab) was associated with significant improvement and stabilization of kidney function. In a separate presentation of results from the same clinical studies, the long-term reduction in hemolysis with Soliris therapy was associated with sustained reduction in thrombosis and improvements in fatigue, overall quality of life, as well as anemia as measured by reductions in transfusions in a diverse population of patients with PNH. Soliris continued to be safe and well- tolerated throughout this open-label study.

The data were presented in two poster presentations titled, "High Incidence of Progression to Chronic Renal Insufficiency in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)" and "Sustained Improvements in Transfusion Requirements, Fatigue and Thrombosis with Eculizumab Treatment in Paroxysmal Nocturnal Hemoglobinuria."

Soliris, Hemolysis and PNH

Soliris, developed by Alexion Pharmaceuticals, Inc. (Nasdaq:

SOURCE Alexion Pharmaceuticals, Inc.
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