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Long-Term Data Updates Show Further Extensions of Survival and Delays in Recurrence in Brain Cancer Patients Who Received DCVax(R)-Brain
Date:10/21/2009

BETHESDA, M.D., Oct. 21 /PRNewswire-FirstCall/ -- Northwest Biotherapeutics, Inc. ("NWBT" or the "Company") (OTC Bulletin Board: NWBO) today announced further long-term follow-up data, for the period from January through September 2009, from its prior Phase I and Phase I/II clinical trials conducted at UCLA with DCVax®-Brain in patients with Glioblastoma multiforme ("GBM"). GBM is the most rapid and lethal type of brain cancer. During the update period, only one of the twenty patients treated with DCVax®-Brain (in addition to standard of care) died, and that patient had survived for nearly 7 years (80.5 months). Overall, 85% of the patients treated with DCVax®-Brain in the Company's prior trials have lived longer than the median survival of only 14.6 months which is achieved with the full standard of care treatment available today (i.e., surgery plus radiation and chemotherapy). Furthermore, 22% of the patients treated with DCVax®-Brain have now reached or exceeded the 6-year survival mark. With standard of care treatment, less than 5% of GBM patients are still alive at 5 years.

The median survival time of the patients treated with DCVax®-Brain in the prior trials is 36.4 months. The difference between this median survival and the median survival achieved with full standard of care treatment has a "p value" of 0.0004. This means that, as a matter of statistical significance, there is only a 4 in 10,000 chance that the DCVax® results are random.

In addition to showing such extended survival, patients treated with DCVax®-Brain in the prior clinical trials have shown striking delays in progression (recurrence) of their cancer. Typically, in spite of surgical removal of the initial tumor, as well as radiation and chemotherapy, GBM brain tumors recur in just 6.9 months. In contrast, in the patients treated with DCVax®-Brain in NWBT's clinical trials, so far 74% of the patients have been fre
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SOURCE Northwest Biotherapeutics, Inc.
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