Navigation Links
Long-Term Data Show Novartis Once-Yearly Reclast Preserves Bone Mass and Provides Fracture Protection in Postmenopausal Osteoporosis
Date:10/16/2010

ence of accelerated bone loss.(1) This builds upon existing data from extensive clinical studies and confirms that Reclast helps preserve bone turnover, the balanced process by which the bone is constantly renewed and remodeled throughout adult life.

"Reclast is highly effective at protecting patients against osteoporotic fractures for a long period of time and its once-yearly dosing represents an important improvement for patients and doctors in terms of compliance for an entire year," said Trevor Mundel, MD, Global Head of Development at Novartis AG. "These long-term data affirm our confidence in the efficacy and safety profile of this medicine."

Osteoporosis is a condition in which bones become weak and break more easily.(4)  According to the National Osteoporosis Foundation (NOF), approximately 10 million people(4) in the US are affected by this disease, which caused approximately 547,000 vertebral fractures in the US in 2005.(4)

This long-term study, which extended the HORIZON (Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly) Pivotal Fracture Trial by three years, is a multi-center, double-blind, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of Reclast in the treatment of postmenopausal osteoporosis.(1) The extension study evaluated more than 1,200 women aged 68 years or older.(1) After three years of therapy, participants were randomized to either receive a Reclast infusion (n=616) or an annual placebo infusion (n=617) for an additional three years.(1)

The primary endpoint of the study was the percentage change in the BMD at the femoral neck at year six vs. year three.(1) Secondary endpoints included evaluation of BMD at other sites, fractures, changes in bone turnover markers and overall safety.(1) The incidence of adverse events was comparable between groups.(1) There was no long-term effect on renal function or increase in risk of osteonecrosis of the jaw or atria
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Long-Term Data on Cimzia® (certolizumab pegol) for Moderate to Severe Crohns Disease to be Highlighted at ACG Meeting
2. Archimedes Pharma Announces Publication of Long-Term Safety and Tolerability Clinical Study of Fentanyl Pectin Nasal Spray (FPNS) in the Journal of Opioid Management
3. NCPA Announces New Division Dedicated to Long-Term Care Pharmacies, Patients
4. Boston Scientific Welcomes Publication of Analysis Demonstrating Long-Term Survival Benefit for ICD Therapy
5. Long-Term Data Show Advantages for TAXUS® Liberte® Stent in Small Vessels and Long Lesions
6. New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years
7. Study of Long-Term Efficacy and Safety of New PyratineXR™ Moisturizing Lotion Featured in Journal of Drugs in Dermatology
8. Partnership for Quality Medical Donations Commits to Long-Term Recovery in Haiti
9. Novus Scientific Announces the Sales Launch for TIGR™ Matrix Surgical Mesh - Worlds 1st Long-Term Resorbable Synthetic Mesh
10. FIRMAGON® Results in Fast, Long-Term Suppression of Testosterone in Prostate Cancer Patients Without Initial Testosterone Surge
11. FDA: Possible Fracture Risk With High Dose, Long-term Use of Proton Pump Inhibitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014  IBM (NYSE: IBM ... ( DESY ), a leading national research center in ... and storage of massive volumes of x-ray data. The ... on IBM software defined technology can handle more than ... and help scientists worldwide gain faster insights into the ...
(Date:8/21/2014)... MISSION, Kan. , Aug. 21, 2014 /PRNewswire-iReach/ ... Information Trust Alliance (HITRUST) under its Common Security ... ScriptPro,s Enterprise Security and Privacy Manager, "We appreciate ... the level of commitment that this certification signifies. ... compliant." ABOUT THE CSF CERTIFICATION PROCESS: ...
(Date:8/21/2014)... percent of Americans believe the abuse of strong prescription pain ... safety issue in the United States , ... & Partners, a Cincinnati based research ... the prescription medication abuse problem and the need for medical ... facing our country," Rex Repass , CEO of the ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3ScriptPro Achieves HITRUST Certification 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... Inc. (Nasdaq: IDIX ), a biopharmaceutical company engaged ... of human viral diseases, today announced that two abstracts have ... the European Association for the Study of the Liver (EASL, ... can now be viewed at the EASL website at www.easl.eu. ...
... (Nasdaq: IDIX ) announced today that management will ... Stock Conference on Monday, March 14, 2011 at 12:00 p.m. ... California and at the Barclays Capital 2011 Global Healthcare Conference ... the Loews Miami Hotel, Florida. The live and ...
Cached Medicine Technology:Idenix Announces Data Presentations at the 46th Annual Meeting of the European Association for the Study of the Liver (EASL) 2Idenix Announces Data Presentations at the 46th Annual Meeting of the European Association for the Study of the Liver (EASL) 3
(Date:8/21/2014)... Albany, NY (PRWEB) August 21, 2014 ... 2020 - Novel Therapeutic Approaches Target High Unmet ... provides in-depth analysis of the Glioblastoma Multiforme (GBM) ... Australia, China, India and Japan. The report provides ... market forecasts until 2020. It also covers disease ...
(Date:8/21/2014)... August 21, 2014 Dr. ... Corporate Health, was recently recognized as one ... in the field of workers’ compensation. , ... Compensation and Occupational Medicine Conference was created ... physicians, nurses, case managers, disability specialists, physical ...
(Date:8/21/2014)... Texas (PRWEB) August 21, 2014 One ... market is likely to experience is an increasing adoption ... increases the compliance of the patient through their convenient ... drug delivery system is a medical device used for ... diseases in the nose and paranasal sinus such as ...
(Date:8/21/2014)... As part of a continuing mission ... has joined with the Alliance for Safe Online Pharmacies ... online sale of medicines. , “Helping to ensure the ... is a core mission for USP and an important ... Ronald T. Piervincenzi, chief executive officer of USP. “The ...
(Date:8/21/2014)... 21, 2014 Hospital officials, community leaders ... ceremony for the new building at Mount Sinai Queens, ... the $125 million expansion and modernization project. During ... from George S. Kaufman, Chairman of the nearby Kaufman ... Ambulatory Care Pavilion will be named. The project, ...
Breaking Medicine News(10 mins):Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 2Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 3Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 4Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 5Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 6Health News:Asia-Pacific Glioblastoma Multiforme (GBM) Market Size Industry Analysis, Share, Growth, Trends and Forecast to 2020: MarketResearchReports.biz 7Health News:Dr. Vasili Gatsinaris Named One of the Top 50 Most Influential in Workers’ Compensation 2Health News:Intranasal Drug Delivery Market 2014 – 2018 Global Forecasts and Analysis in New Research Report at Sandlerresearch.org 2Health News:Intranasal Drug Delivery Market 2014 – 2018 Global Forecasts and Analysis in New Research Report at Sandlerresearch.org 3Health News:Intranasal Drug Delivery Market 2014 – 2018 Global Forecasts and Analysis in New Research Report at Sandlerresearch.org 4Health News:Intranasal Drug Delivery Market 2014 – 2018 Global Forecasts and Analysis in New Research Report at Sandlerresearch.org 5Health News:USP Joins Efforts to Halt Illegal Online Drug Sales 2Health News:“Topping Off” Ceremony Marks Major Milestone in Mount Sinai Queens Construction Project 2Health News:“Topping Off” Ceremony Marks Major Milestone in Mount Sinai Queens Construction Project 3Health News:“Topping Off” Ceremony Marks Major Milestone in Mount Sinai Queens Construction Project 4
... ON, Sept. 17 /PRNewswire-FirstCall/ - AlphaRx Inc. ... to developing the next,generation of therapeutic products ... candidate, Streptomycin nanoparticles,will be the subject of ... in,Treatment and Pathogenesis of Mycobacterial Infections" at ...
... Company Serves as a Free Resource to Employees Seeking Senior ... ... the nation,s largest,referral service of senior care options, was recently recognized in ... to when an,employer does not offer eldercare assistance as a part of ...
... genes can work in more powerful and sneaky ways than ... JAK that is closely related to a common cancer-causing gene ... manner. JAK disrupts the activity of an organisms DNA on ... on in an embryos development. , A team from the ...
... Hotel, Washington, D.C.,National and International Health Care Professionals will Convene to ... ... Failure Patients, WASHINGTON, Sept. 17 ... convenes Sunday, September,16, 2007 at the Marriott Wardman Park Hotel in ...
... out of 4 Slept Better on New Sleep Better(TM) ... effort to test the,connection between a new, quality bed ... townspeople of Pillow, Pa. let go of one of ... Sleep Better(TM),Project. Residents of this central Pennsylvania bedroom ...
... 16, 2007 New findings by UT Southwestern Medical ... interferes with the beneficial effects estrogen has on the ... between cholesterol and estrogen in heart disease. , The ... October issue of the journal Nature Medicine , ...
Cached Medicine News:Health News:AlphaRx To Present at 47th Annual ICAAC 2Health News:A Place for Mom, Nation's Largest Senior Care Referral Service, Fills a Gap in Employee Benefits 2Health News:If you think cancer genes are simple, you don't know JAK 2Health News:If you think cancer genes are simple, you don't know JAK 3Health News:If you think cancer genes are simple, you don't know JAK 4Health News:If you think cancer genes are simple, you don't know JAK 5Health News:Heart Failure Society of America 11th Annual Scientific Meeting to Focus on Heart Failure Guidelines, Innovation and New Research 2Health News:Heart Failure Society of America 11th Annual Scientific Meeting to Focus on Heart Failure Guidelines, Innovation and New Research 3Health News:Pillow, PA's Great American Sleep Better(TM)Project Reports Results 2Health News:Pillow, PA's Great American Sleep Better(TM)Project Reports Results 3Health News:Cholesterol byproduct blocks heart health benefits of estrogen 2Health News:Cholesterol byproduct blocks heart health benefits of estrogen 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: