Navigation Links
Long-Term Data Show Novartis Once-Yearly Reclast Preserves Bone Mass and Provides Fracture Protection in Postmenopausal Osteoporosis
Date:10/16/2010

ence of accelerated bone loss.(1) This builds upon existing data from extensive clinical studies and confirms that Reclast helps preserve bone turnover, the balanced process by which the bone is constantly renewed and remodeled throughout adult life.

"Reclast is highly effective at protecting patients against osteoporotic fractures for a long period of time and its once-yearly dosing represents an important improvement for patients and doctors in terms of compliance for an entire year," said Trevor Mundel, MD, Global Head of Development at Novartis AG. "These long-term data affirm our confidence in the efficacy and safety profile of this medicine."

Osteoporosis is a condition in which bones become weak and break more easily.(4)  According to the National Osteoporosis Foundation (NOF), approximately 10 million people(4) in the US are affected by this disease, which caused approximately 547,000 vertebral fractures in the US in 2005.(4)

This long-term study, which extended the HORIZON (Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly) Pivotal Fracture Trial by three years, is a multi-center, double-blind, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of Reclast in the treatment of postmenopausal osteoporosis.(1) The extension study evaluated more than 1,200 women aged 68 years or older.(1) After three years of therapy, participants were randomized to either receive a Reclast infusion (n=616) or an annual placebo infusion (n=617) for an additional three years.(1)

The primary endpoint of the study was the percentage change in the BMD at the femoral neck at year six vs. year three.(1) Secondary endpoints included evaluation of BMD at other sites, fractures, changes in bone turnover markers and overall safety.(1) The incidence of adverse events was comparable between groups.(1) There was no long-term effect on renal function or increase in risk of osteonecrosis of the jaw or atria
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Long-Term Data on Cimzia® (certolizumab pegol) for Moderate to Severe Crohns Disease to be Highlighted at ACG Meeting
2. Archimedes Pharma Announces Publication of Long-Term Safety and Tolerability Clinical Study of Fentanyl Pectin Nasal Spray (FPNS) in the Journal of Opioid Management
3. NCPA Announces New Division Dedicated to Long-Term Care Pharmacies, Patients
4. Boston Scientific Welcomes Publication of Analysis Demonstrating Long-Term Survival Benefit for ICD Therapy
5. Long-Term Data Show Advantages for TAXUS® Liberte® Stent in Small Vessels and Long Lesions
6. New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years
7. Study of Long-Term Efficacy and Safety of New PyratineXR™ Moisturizing Lotion Featured in Journal of Drugs in Dermatology
8. Partnership for Quality Medical Donations Commits to Long-Term Recovery in Haiti
9. Novus Scientific Announces the Sales Launch for TIGR™ Matrix Surgical Mesh - Worlds 1st Long-Term Resorbable Synthetic Mesh
10. FIRMAGON® Results in Fast, Long-Term Suppression of Testosterone in Prostate Cancer Patients Without Initial Testosterone Surge
11. FDA: Possible Fracture Risk With High Dose, Long-term Use of Proton Pump Inhibitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 2014 BreedIT Corp (OTC: BRDT), ... distributor of highly sophisticated agro-breeding solutions for plant breeders ... the Company,s board of directors appointed chemistry and pharmaceutical ... new member of the board. From 1975 ... Pharmaceutical Industries Ltd (NYSE: TEVA ) and ...
(Date:1/15/2014)... -- Tegra Medical is very pleased to announce the ... its new Chief Executive Officer.  Mark was promoted from ... he has overseen the company,s four facilities in ... and Costa Rica.  Mr. King joined Tegra Medical in ... and manufacturing experience in medical device businesses, both in ...
(Date:1/15/2014)... 2014 The Cadence Fitness & Health ... Center by the Medical Fitness Association, a non-profit ... to achieve their full potential. The Cadence Fitness ... center in the western suburbs and second in ... the Cadence Fitness & Health Center meets guidelines ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... Cochlear, the global leader in implantable hearing ... Clark Cochlear Scholarship. Presented by Cochlear Americas, the Graeme ... seniors who,ve demonstrated exceptional achievements both in the classroom ... implant and will receive financial assistance toward their chosen ...
... PHILADELPHIA , May 4 ... SHPGY ), the global specialty biopharmaceutical company, today announced ... a change to the prescribing information for its once-daily ... ® (lisdexamfetamine dimesylate) Capsules CII, to include supplemental ...
Cached Medicine Technology:Cochlear Americas Honors Achievements of Cochlear Implant Recipients during May's Better Hearing & Speech Month 2Cochlear Americas Honors Achievements of Cochlear Implant Recipients during May's Better Hearing & Speech Month 3Cochlear Americas Honors Achievements of Cochlear Implant Recipients during May's Better Hearing & Speech Month 4FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 2FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 3FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 4FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 5FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 6FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 7FDA Approves Labeling Change for Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII to Include Supplemental Data Demonstrating Significant Efficacy at Two Hours Through 14 Hours After Administration in Adults with ADHD 8
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... of the reasons why bladder cancer is so much more ... that is much more active// in men than women plays ... could open the door to new types of treatment with ... of the National Cancer Institute, Chawnshang Chang, Ph.D., of the ...
... pancreatic cancer developed has successfully stalled the disease from ... The results provide promising evidence that the vaccine can ... pancreatic cancer and offer new insights into how the ... ,"Pancreatic cancer is extremely resistant to chemotherapy ...
... of international health experts issues a bold call to the ... to fund the salaries of health workers or else risk ... made available in poor countries but there are no health ... inside of the Global Fund," say Gorik Ooms (Medecins Sans ...
... Water scarcity has become a universal problem. With a ... been taken up in the country.// ,In a ... average annual rainfall in India is about 1170 mm. ... rainfall. ,The release further said that there had ...
... rise of the central nervous system [CNS] in animal ... worms evolved// from the same ancestor, but their CNSs ... after their lineages had split during evolution. Researchers from ... reveal that the vertebrate nervous system is probably much ...
... family turmoil, violence, noise, poor housing or other chronic ... organs and tissues than other young people. ... not experience these negative physiological changes, reports a new ... also found that the cardiovascular systems of youths who ...
Cached Medicine News:Health News:Scientists Find Clue for the Prevalence of Bladder Cancer More in Men 2Health News:Scientists Find Clue for the Prevalence of Bladder Cancer More in Men 3Health News:Scientists Find Clue for the Prevalence of Bladder Cancer More in Men 4Health News:Vaccine for Pancreatic Cancer Halts Progression of Disease in Some Patients 2Health News:Health Expert’s Appeal to Global Fund to Fight HIV, TB and Malari 2Health News:Stress on Storage and Conservation of Rain Water by Govt of India 2Health News:The Origin of the Brain Lies in a Worm 2Health News:Family Turmoil and Violence Results in Stress-induced Physical Problems in Young, Cornell Psychologist Finds 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: