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Long Term Data Presented at EuroPCR 2009 from Randomized Study Attest to Durability of Results of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Compared to Drug-Eluting Stents
Date:5/20/2009

mm) and/or chronic total occlusions. Two year follow up was obtained in all patients, with the exception of one.

The next generation of pro-healing stent technologies was highlighted in separate presentations, one focusing on pre-clinical results of an endothelial cell capture (EPC) surface on an abluminal, low dose sirolimus eluting stent (pro-healing SES), the other focusing on the company's bioabsorbable stent developments.

Greg Kaluza, M.D., Ph.D., Director of Operations at the Jack H. Skirball Center for Cardiovascular Research in New York, presented the pro-healing SES's pre-clinical results from multiple models supporting the soon to be initiated first in human study. The pro-healing SES demonstrated significantly lower neointimal hyperplasia, while also showing improved endothelial coverage relative to two other commercially available DES. There was also a noticeably lower presence of inflammation and foreign body reaction. "These data are remarkably promising across all criterion," said Kaluza. "For the first time, a DES appears effective at inhibition of neointima while enhancing endothelial coverage early on."

Development of the company's bioabsorbable stent program was presented by Robert Cottone, vice president of intellectual property and technologies. Angiographic and optical coherence tomography (OCT) imagery were reviewed illustrating the new stent platform's deliverability, design features, and vessel scaffolding. "The nature of the polymeric materials allows for tremendous innovation in stent design and functionality," said Cottone. "With this new platform, combined with our coating technologies, we will be able to achieve clinical vascular restoration therapies simply not possible with metal."

Unlike drug-eluting stents, Genous, which is coated with an antibody, captures a patient's EPCs to accelerate the natural healing process. EPCs circulate in the bloodstream an
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