Logical Therapeutics to Present Data on LT-NS001 at American College of Gastroenterology Annu...( WALTHAM Mass. Oct. 20 -- Logical The...),Health

WALTHAM, Mass., Oct. 20 /PRNewswire-USNewswire/ -- Logical Therapeutics, Inc. (Logical), a biopharmaceutical company focused on developing products that treat medical conditions associated with inflammation, has been selected to present the results of its clinical study comparing the gastrointestinal (GI) safety of its lead product LT-NS001, vs. naproxen at the American College of Gastroenterology's (ACG) Annual Scientific Meeting on October 27, 2009.

LT-NS001 is the first in a new class of bio-activated pro-drugs. It is a novel, patented new chemical entity (NCE) pro-drug of the popular non-steroidal anti-inflammatory drug (NSAID) naproxen, which is being developed by Logical Therapeutics to significantly reduce the gastrointestinal (GI) safety risks, including the formation of ulcers, associated with naproxen.

"We are very encouraged by the results of the LT-NS001 vs. naproxen study, and we look forward to sharing them later this month at the ACG meeting," said Peter A. Lankau, chief executive officer of Logical Therapeutics. "This novel, bio-activated pro-drug is being developed to fulfill an unmet need in the marketplace - to provide a single agent capable of delivering relief to those who suffer from chronic inflammatory conditions like arthritis, while significantly improving the GI safety and tolerability as compared to naproxen."

LT-NS001 Well-Tolerated with No Serious Adverse Events

LT-NS001 is unique among NSAIDs as it is pharmacologically inactive as a Cox inhibitor in the GI tract, but once absorbed into the bloodstream, it is converted rapidly and quantitatively to naproxen. In previous clinical studies, LT-NS001 was well-tolerated with no serious adverse events. In pre-clinical testing, LT-NS001 demonstrated significantly less damage to the gastrointestinal tract than equivalent doses of naproxen. Naproxen is widely regarded as the NSAID with the most favorable cardiovascular safety prof
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