Navigation Links
Logical Therapeutics to Present Data on LT-NS001 at American College of Gastroenterology Annual Meeting

WALTHAM, Mass., Oct. 20 /PRNewswire-USNewswire/ -- Logical Therapeutics, Inc. (Logical), a biopharmaceutical company focused on developing products that treat medical conditions associated with inflammation, has been selected to present the results of its clinical study comparing the gastrointestinal (GI) safety of its lead product LT-NS001, vs. naproxen at the American College of Gastroenterology's (ACG) Annual Scientific Meeting on October 27, 2009.

LT-NS001 is the first in a new class of bio-activated pro-drugs. It is a novel, patented new chemical entity (NCE) pro-drug of the popular non-steroidal anti-inflammatory drug (NSAID) naproxen, which is being developed by Logical Therapeutics to significantly reduce the gastrointestinal (GI) safety risks, including the formation of ulcers, associated with naproxen.

"We are very encouraged by the results of the LT-NS001 vs. naproxen study, and we look forward to sharing them later this month at the ACG meeting," said Peter A. Lankau, chief executive officer of Logical Therapeutics. "This novel, bio-activated pro-drug is being developed to fulfill an unmet need in the marketplace - to provide a single agent capable of delivering relief to those who suffer from chronic inflammatory conditions like arthritis, while significantly improving the GI safety and tolerability as compared to naproxen."

LT-NS001 Well-Tolerated with No Serious Adverse Events

LT-NS001 is unique among NSAIDs as it is pharmacologically inactive as a Cox inhibitor in the GI tract, but once absorbed into the bloodstream, it is converted rapidly and quantitatively to naproxen. In previous clinical studies, LT-NS001 was well-tolerated with no serious adverse events. In pre-clinical testing, LT-NS001 demonstrated significantly less damage to the gastrointestinal tract than equivalent doses of naproxen. Naproxen is widely regarded as the NSAID with the most favorable cardiovascular safety profile among all of the drugs in this class.

In this study, subjects underwent upper endoscopies at baseline and on day seven. Subjects receiving LT-NS001 experienced significantly fewer endoscopically-confirmed gastric ulcers compared to subjects receiving naproxen. The full results from this study will be presented at the American College of Gastroenterology meeting on October 27 in San Diego, Calif.

"In the U.S. alone, the direct costs of treating ulcer complications associated with NSAID use exceed $4 billion annually, and serious complications such as hemorrhage and perforation are directly responsible for approximately 20,000 deaths per year," Lankau said. "LT-NS001 has the potential to help bring down these costs and reduce serious complications for patients whose need for NSAID anti-inflammatory treatment is complicated by significant gastrointestinal risks."

About Logical Therapeutics Inc.

Based in Waltham, MA, Logical Therapeutics, Inc. is a venture-backed, privately held biotechnology company focused on the development of products that treat diseases associated with inflammation. Logical's investors include SV Life Sciences, Burrill and Company, Novo Ventures A/S, and Novitas Capital. For more information on Logical Therapeutics, visit the company's website at

Please address inquiries regarding LT-NS001 to Logical Therapeutics' business development department at

SOURCE Logical Therapeutics, Inc.

SOURCE Logical Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Article Published in Expert Opinion on Biological Therapy Evaluates StemEx(R) (carlecortemcel-l) for Leukemia and Lymphoma
2. Interim Phase II Data Presented at XIV World Congress of Neurological Surgery Supports Potential of Peregrines Cotara(R) for Treatment of Brain Cancer
3. Cytel Signs Cooperative Research And Development Agreement With FDA Center for Devices and Radiological Health (CDRH)
4. Clinical and Histopathological Results Using Pollogens TriPollar(TM) Radio Frequency Technology Published in the June Issue of the Journal of Cosmetic and Laser Therapy
5. Neurobiological Technologies Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program
6. Logical Therapeutics Appoints Peter A. Lankau as CEO and Director
7. Neurobiological Technologies Reports Receipt of $1.5 Million Royalty Payment for Quarterly Sales of Memantine
8. Genetic Research Leads to New Discovery in Understanding Rare Neurological Disorder
9. Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
10. Neurobiological Technologies Announces Viprinex(TM) Does Not Pass Interim Futility Analysis
11. The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Countrys Biological Preparedness
Post Your Comments:
(Date:12/1/2015)... --> --> ... by Type of Drug (Monoclonal Antibodies, Interferon-Alpha, Interleukins, Vaccines, (Therapeutic ... Analysis - Global Forecast to 2020", published by MarketsandMarkets, the ... Million by 2020 from USD 40,281.6 Million in 2015, at ... Browse 37 market data T ...
(Date:12/1/2015)... 2015 Assurex Health, Inc. today announced ... healthcare providers an expanded range of options in ... from depression, anxiety, bipolar disorder, posttraumatic stress disorder ... i .   --> ... addition of two new drug classes, 17 FDA-approved ...
(Date:12/1/2015)... , Dec. 1, 2015  Six months of adjunctive metformin ... type 1 diabetes, according to new research from T1D ... it may have a beneficial effect on measures of obesity, ... issue of the Journal of the American Medical Association ... the effect of metformin on overweight and obese adolescents with ...
Breaking Medicine Technology:
(Date:12/1/2015)... ... 02, 2015 , ... Ruth Pearson was struggling. She had been laid off ... assistance and quickly losing hope of recovering her former life, Pearson was desperate for ... attending a women’s retreat when she experienced a particularly impactful worship service. Without help ...
(Date:12/1/2015)... ... December 01, 2015 , ... On Tuesday ... to NASDAQ to educate the personnel on spinal decompression therapy and offer his ... a nonsurgical procedure. The benefits come from creating negative intradiscal pressure which is ...
(Date:12/1/2015)... ... December 01, 2015 , ... Henderson, a ... to receive Gigabit Internet through a partnership this year with Aeneas Internet and ... is an attractive destination for entrepreneurs who want to build a business. Whether ...
(Date:12/1/2015)... ... , ... Florida Hospital Tampa is the first health care provider in the region ... , vBloc® Therapy is a vagal blocking therapy, delivered via the Maestro® System, for the ... (BMI) of at least 40 to 45 kg, or a BMI of at least 35 ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... Califia ... today announced that its iconic bottle has won top honors in Beverage World Magazine’s ... The Company also announced that it has been selected as a 2015 U.S.A. Taste ...
Breaking Medicine News(10 mins):