Navigation Links
Liquid Tissue(R) Patent Licensed for Amyloidosis Proteomic Assay
Date:11/17/2009

ROCKVILLE, Md., Nov. 17 /PRNewswire/ -- Expression Pathology, a leader in tissue proteomic analysis, today announced Mayo Clinic has licensed non-exclusive rights to Expression Pathology's Liquid Tissue® patent for use in diagnosis of systemic amyloidosis in formalin-fixed tissue.

Patented Liquid Tissue® methodology enables solubilization of proteins for mass spectrometric analysis of formalin-fixed paraffin-embedded (FFPE) tissue, the standard form of preserved patient tissue used in clinical pathology testing worldwide. Mayo Clinic has applied the technology to develop a specific and sensitive mass spectrometry based method for diagnosis and classification of amyloidosis in routine biopsy specimens, in a format that is rapid and readily applicable in a clinical setting. This test is being offered to patients worldwide through Mayo Medical Laboratories, Mayo Clinic's reference laboratory.

With 50,000 diagnosed cases every year worldwide amyloidosis can be a localized or systemic disease, characterized by organ function impairment, sometimes as severe as cardiac and/or renal failure. Subtyping of cases is critical as management of the disease differs radically, from drug therapies to major organ transplants.

The new Liquid Tissue-based method aids in treatment decisions as it exhibits greater sensitivity and specificity than the traditional IHC based classification. In an early case study of 56 FFPE cardiac biopsies involving amyloidosis immunohistochemistry was diagnostic in 19/52 cases and equivocal in 33/52 cases (4 cases no IHC). The mass spectrometry-based Liquid Tissue method identified the amyloidosis type in 53 of 56 cases studied.

"Detailed mass spectrometry analysis of proteins related to specific disease conditions in FFPE tissue is opening huge opportunities in personalized medicine to relate those measurements to patient treatment decisions," said Casey Eitner, President and CEO of Expression Pathology. "We are delighted that Mayo Clinic has applied our Liquid Tissue® methodology to solve a difficult medical problem."

Financial terms of the agreement were not disclosed.

About Mayo Medical Laboratories

Mayo Clinic offers proven diagnostic tests to more than 5,000 health care institutions around the world through Mayo Medical Laboratories, Mayo Clinic's reference laboratory. Revenue from Mayo Medical Laboratories' testing is used to support medical education and research at Mayo Clinic. www.MayoMedicalLaboratories.com

About Expression Pathology Inc.

Expression Pathology Inc., Rockville, MD, has developed proprietary techniques for discovery and quantitative analysis of protein biomarkers in FFPE tissue. The company's Director® laser microdissection slides enable precise, rapid, automated collection of specific cellular features from tumor tissue. Its Liquid Tissue® reagents and technology make possible discovery and measurement of proteins in FFPE tissue by mass spectrometry. EPI employs its Liquid Tissue® proteomics platform in its own and collaborative assay development and biomarker discovery programs, and offers contract research services and products. For more information, please visit www.expressionpathology.com.

    Expression Pathology contact:

    Peter Tunon
    VP Sales and Marketing
    Expression Pathology Inc.
    9620 Medical Center Drive
    Rockville, MD 20850
    301.977.3654
    Email p.tunon@expressionpathology.com

SOURCE Expression Pathology Inc.


'/>"/>
SOURCE Expression Pathology Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Baxter and The Alzheimers Disease Cooperative Study Group to Pursue a Phase III Study of Gammagard Liquid in Patients With Alzheimers Disease
2. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
3. Study Results of GAMMAGARD S/D and GAMMAGARD LIQUID in Patients with Mild-to-Moderate Alzheimers Disease Announced
4. Advocate Christ Medical Center Using Glue-Like Liquid to Seal Off Brain Aneurysms
5. New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
6. NeurogesX Initiates Dosing in Phase 1 Clinical Trial for NGX-1998 Capsaicin Liquid Formulation
7. White Paper Explains Aspects of Testing From Purified Bulk Drug Substance to Sterile Liquid Final Drug Product
8. Xanodyne Expands U.S. Sales Force and Launches Zipsor(TM) (diclofenac potassium) Liquid Filled Capsules
9. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
10. ArtJen Announces Major Clinical Trial of Its Patented Weight Loss Product FBCx
11. FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Conference Call and Webcast to Follow Vanda Pharmaceuticals Inc. ... results for the fourth quarter of 2016 on Wednesday, February 15, ... ... PM ET on Wednesday, February 15, 2017, during which management will ... other corporate activities. To participate in the conference call, please dial ...
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin ... global anti-obesity drugs market is expected to grow at ... period and CAGR of 38.7% in the second half of the ... of 32.8% from 2016 to 2027. The market is estimated at ... in 2027. ...
(Date:1/19/2017)... 19, 2017  Sensus Healthcare, Inc. (NASDAQ: ... in the treatment of non-melanoma skin cancers and ... radiation therapy, today announced that it will report ... results on Thursday, February 2, 2017 after the market ... conference call with the investment community on Thursday, February ...
Breaking Medicine Technology:
(Date:1/21/2017)... ... ... the perfect set of tools for video editors that want to create the illusion of ... CEO of Pixel Film Studios. , Video editors using ProDOF can add realistic depth ... focus from one area into the next. ProDOF comes with 0.5 second, 1.0 second, ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Redwood Family Dermatology has recently joined their multi-specialty medical group. The dermatology ... of cosmetic services. , “We’re excited to add this excellent dermatology practice to ...
(Date:1/20/2017)... ... ... New ADA Portable Motion Trek BP 300 Lift. Built for durability, this pool lift is ... be wheeled out of the way and stored when not in use. It is freestanding ... feedback from customers into specific enhancements and created a new product that is built directly ...
(Date:1/20/2017)... , ... January 20, 2017 , ... Doctor C LLC, ... attended the January ECRM trade show to continue the marketing and distribution of its ... supplement, known for providing 400 percent better absorption than traditional vitamin C supplements. At ...
(Date:1/20/2017)... FL (PRWEB) , ... January 20, 2017 , ... International ... of nutritional and bodybuilding supplements, announced it attended the January ECRM trade show in ... bodybuilder and nutritional scientist who was determined to create a line of products that ...
Breaking Medicine News(10 mins):