Navigation Links
Liquid Tissue(R) Patent Licensed for Amyloidosis Proteomic Assay
Date:11/17/2009

ROCKVILLE, Md., Nov. 17 /PRNewswire/ -- Expression Pathology, a leader in tissue proteomic analysis, today announced Mayo Clinic has licensed non-exclusive rights to Expression Pathology's Liquid Tissue® patent for use in diagnosis of systemic amyloidosis in formalin-fixed tissue.

Patented Liquid Tissue® methodology enables solubilization of proteins for mass spectrometric analysis of formalin-fixed paraffin-embedded (FFPE) tissue, the standard form of preserved patient tissue used in clinical pathology testing worldwide. Mayo Clinic has applied the technology to develop a specific and sensitive mass spectrometry based method for diagnosis and classification of amyloidosis in routine biopsy specimens, in a format that is rapid and readily applicable in a clinical setting. This test is being offered to patients worldwide through Mayo Medical Laboratories, Mayo Clinic's reference laboratory.

With 50,000 diagnosed cases every year worldwide amyloidosis can be a localized or systemic disease, characterized by organ function impairment, sometimes as severe as cardiac and/or renal failure. Subtyping of cases is critical as management of the disease differs radically, from drug therapies to major organ transplants.

The new Liquid Tissue-based method aids in treatment decisions as it exhibits greater sensitivity and specificity than the traditional IHC based classification. In an early case study of 56 FFPE cardiac biopsies involving amyloidosis immunohistochemistry was diagnostic in 19/52 cases and equivocal in 33/52 cases (4 cases no IHC). The mass spectrometry-based Liquid Tissue method identified the amyloidosis type in 53 of 56 cases studied.

"Detailed mass spectrometry analysis of proteins related to specific disease conditions in FFPE tissue is opening huge opportunities in personalized medicine to relate those measurements to patient treatment decisions," said Casey Eitner, President and CEO of Expression Pathology. "We are delighted that Mayo Clinic has applied our Liquid Tissue® methodology to solve a difficult medical problem."

Financial terms of the agreement were not disclosed.

About Mayo Medical Laboratories

Mayo Clinic offers proven diagnostic tests to more than 5,000 health care institutions around the world through Mayo Medical Laboratories, Mayo Clinic's reference laboratory. Revenue from Mayo Medical Laboratories' testing is used to support medical education and research at Mayo Clinic. www.MayoMedicalLaboratories.com

About Expression Pathology Inc.

Expression Pathology Inc., Rockville, MD, has developed proprietary techniques for discovery and quantitative analysis of protein biomarkers in FFPE tissue. The company's Director® laser microdissection slides enable precise, rapid, automated collection of specific cellular features from tumor tissue. Its Liquid Tissue® reagents and technology make possible discovery and measurement of proteins in FFPE tissue by mass spectrometry. EPI employs its Liquid Tissue® proteomics platform in its own and collaborative assay development and biomarker discovery programs, and offers contract research services and products. For more information, please visit www.expressionpathology.com.

    Expression Pathology contact:

    Peter Tunon
    VP Sales and Marketing
    Expression Pathology Inc.
    9620 Medical Center Drive
    Rockville, MD 20850
    301.977.3654
    Email p.tunon@expressionpathology.com

SOURCE Expression Pathology Inc.


'/>"/>
SOURCE Expression Pathology Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Baxter and The Alzheimers Disease Cooperative Study Group to Pursue a Phase III Study of Gammagard Liquid in Patients With Alzheimers Disease
2. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
3. Study Results of GAMMAGARD S/D and GAMMAGARD LIQUID in Patients with Mild-to-Moderate Alzheimers Disease Announced
4. Advocate Christ Medical Center Using Glue-Like Liquid to Seal Off Brain Aneurysms
5. New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
6. NeurogesX Initiates Dosing in Phase 1 Clinical Trial for NGX-1998 Capsaicin Liquid Formulation
7. White Paper Explains Aspects of Testing From Purified Bulk Drug Substance to Sterile Liquid Final Drug Product
8. Xanodyne Expands U.S. Sales Force and Launches Zipsor(TM) (diclofenac potassium) Liquid Filled Capsules
9. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
10. ArtJen Announces Major Clinical Trial of Its Patented Weight Loss Product FBCx
11. FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... April 25, 2017 Endo International plc (NASDAQ: ... 2017. Members of its senior management team will host a conference ... a.m. ET. The dial-in number to access the ... 509-7598, and the passcode is 6086379. Please dial in 10 minutes ... A replay of the call will be available from May ...
(Date:4/20/2017)... , April 20, 2017  Vivify Health, the ... devices, has been awarded a very significant patent for ... EMRs to continual care via digital health.  This landmark ... intellectual property and further secures Vivify,s position as the ... in 2009, was the first company to apply consumer ...
(Date:4/20/2017)... R.I. , April 20, 2017  CVS ... CVS), today unveiled a new store design to ... assortment of healthier food, health-focused products and expanded ... store to help customers discover new offerings. Together ... the next evolution of the customer experience at ...
Breaking Medicine Technology:
(Date:4/28/2017)... ... April 28, 2017 , ... Bill Howe started his sewer and drain company ... Tina Howe joined the team, the Bill Howe brand was born and they began ... and giving back to the San Diego community in which they worked, lived and ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at Moffitt ... ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled in an ... and sleep monitoring solutions for the global scientific community. The company’s new CentrePoint ...
(Date:4/28/2017)... ... April 28, 2017 , ... Intellitec Solutions announced the ... implement a Microsoft Dynamics GP solution that integrates to their PointClickCare EHR software ... in long-term care, Brooke Grove now has the capability to achieve its goal ...
(Date:4/28/2017)... Mateo, CA (PRWEB) , ... April 28, 2017 , ... ... Area cities as diverse as Millbrae, Burlingame, and Palo Alto, is proud to announce ... allow interested persons to bookmark and read organized content on topics such as home ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular ... premier online modeling resource for fluorescence microscopists and optical system designers, enabling The ... 5 years spanning the globe, SearchLight has become a tremendously popular tool for ...
Breaking Medicine News(10 mins):