Navigation Links
Lilly and Incyte's Oral JAK1 and JAK2 Inhibitor, Baricitinib, Showed Positive Results in Phase IIb Study in Patients with Active Rheumatoid Arthritis
Date:6/8/2012

BERLIN, June 8, 2012 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) and Incyte Corporation (Nasdaq: INCY) announced the presentation of 12-week results from a Phase IIb study of baricitinib, formerly LY3009104 (INCB28050), an orally available janus kinase (JAK) inhibitor, in patients with active rheumatoid arthritis (RA). The results were presented as a late-breaking oral presentation at the European League Against Rheumatism's (EULAR) Annual European Congress of Rheumatology [EULAR abstract LB0005: 12-Week Results of a Phase IIb Dose-Ranging Study of LY3009104 (INCB028050), an Oral JAK1/JAK2 Inhibitor, in Combination with Traditional DMARDs in Patients with Rheumatoid Arthritis].

The Phase IIb randomized double-blind, placebo-controlled, dose-ranging study, known as JADA, involved a total of 301 patients with active RA on stable doses of methotrexate. Patients were randomized to receive either placebo or one of four once-daily doses of baricitinib (1 mg, 2 mg, 4 mg or 8 mg) for 12 weeks.

Primary Endpoint Achieved

The Phase IIb trial achieved the primary endpoint by demonstrating a statistically significant difference in the American College of Rheumatology 20 (ACR20) response between the combined 4 mg and 8 mg baricitinib groups (76 percent) compared with placebo (41 percent) after 12 weeks of treatment (p<0.001). Statistically significant improvement was observed at the first assessment point after two weeks of treatment and was sustained through week 12.

Summary of Secondary Endpoints

A statistically significant difference in response for the ACR20, ACR50 and ACR70 secondary endpoints was observed with the 1 mg, 4 mg and 8 mg dose groups compared with placebo.

ACR20

  • 8 mg: 78 percent (p<0.001)
  • 4 mg: 75 percent (p<0.001)
  • 2 mg: 54 percent (
    '/>"/>

SOURCE Eli Lilly and Company; Incyte Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lilly Diabetes Presents Phase II Blood Pressure and Heart Rate Data on Investigational GLP-1 Analog Candidate, Dulaglutide, in Patients with Type 2 Diabetes at the 27th American Society of Hypertension Scientific Meeting
2. Lilly Oncology To Disclose New Pipeline Data At ASCO 2012
3. Lilly Applauds Law Enforcement Officials for their Successful Investigation and Recovery of Pharmaceuticals Stolen from Connecticut Distribution Center
4. Lilly Sets Date for Lilly Diabetes Pipeline Update to the Investment Community
5. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
6. DiversityInc Names Lilly a Top Company for Diversity
7. Study Showed Patients Treated With The miraDry© System Experienced 82 Percent Sweat Reduction On Average
8. InspireMD Announces Positive 3-Year Results from Extended MAGICAL trial
9. Boehringer Ingelheim to present pivotal Phase III results for afatinib in first-line treatment of EGFR mutation-positive NSCLC at ASCO 2012
10. Boston Scientific Announces Positive Data From Lotus™ Transcatheter Aortic Valve Trial
11. Life Extension Foundation® study finds Cognitex® with NeuroProtection Complex may provide a positive impact on cognitive performance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... ITHACA, N.Y. , Aug. 22, 2014 /PRNewswire/ ... computed tomography (CT) imaging facility, is using the ... 4D and even 5D imaging to researchers and ... just launched, asks "What would YOU do if ... the possibility to researchers and explorers everywhere, from ...
(Date:8/22/2014)... 22, 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... commercializes proprietary technologies and products for advanced microarray ... a Master Service Agreement to contract with a ... assays. During the initial phase of this agreement, ... working prototype of one of the customer,s assays, ...
(Date:8/21/2014)... AUSTIN, Texas , Aug. 21, 2014  Vermillion, ... company focused on gynecologic cancers and women,s health, has ... of Sales and Managed Markets. Ms. Bauzon ... traction and expanding payer coverage for laboratory services companies. ... most recently with PerkinElmer, Inc., where she held the ...
Breaking Medicine Technology:Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 3Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2
(Date:8/22/2014)... The leather seat covers provided by ... to meet customers’specific product needs. Recently, the company has unveiled ... , The company wants to provide worldwide clients with ... seat cover industry for a long time. According to the ... at promotional rates. Among all the new products, Chevrolet ...
(Date:8/22/2014)... AcousticSheep LLC participated in one of the ... first Color Run – otherwise known as the “Happiest 5K on ... over 10,900 participants from Erie, surrounding areas, and even from as ... of the largest running events put on in Erie, PA yet ... 5K on the Planet.” The event took place on August 9, ...
(Date:8/22/2014)... August 22, 2014 For the fourth ... reward and recognition industry, has received a prestigious level ... growth rate of 134%, TharpeRobbins remains on the exclusive ... America. TharpeRobbins was previously on the list in 2010, ... be included in this distinguished list for a fourth ...
(Date:8/22/2014)... Minorities in Orange and Los Angeles counties are among ... and recovery from trauma. Casa de Familia is one local ... minorities and the help they need. A local fitness ... between mental and physical health. , Fountain Valley Fit Body ... camp, located at 16560 Harbor Blvd., Suite D in Fountain ...
(Date:8/22/2014)... Medical Solutions, the nation’s third-largest Travel Nurse ... the Inc. 5000 list, amongst a highly competitive field. ... on the list, with 300% growth over a 3-year ... seventh time in the last eight years that Medical ... including one year on the Inc. 500, indicating an ...
Breaking Medicine News(10 mins):Health News:Custom 1993-1996 Chevrolet Camaro Leather Seat Covers Now for Sale at Lseat.com 2Health News:RunPhones® Reveals Erie, PA Enthusiasm Impressed Color Run Director 2Health News:RunPhones® Reveals Erie, PA Enthusiasm Impressed Color Run Director 3Health News:For The Fourth Time - TharpeRobbins Earns A Place On Prestigious Inc. Magazine 500|5000 List 2Health News:For The Fourth Time - TharpeRobbins Earns A Place On Prestigious Inc. Magazine 500|5000 List 3Health News:Fountain Valley Fit Body Boot Camp Announces Fitness Boot Camp Fundraising Event for Casa de Familia 2Health News:Fountain Valley Fit Body Boot Camp Announces Fitness Boot Camp Fundraising Event for Casa de Familia 3Health News:Medical Solutions Earns Position on the 2014 Inc. 5000 List 2
... , , ... CVS ) announced today that it has named Andrew ... the company,s retail-based health clinic subsidiary, and as Senior Vice President/Associate ... Dr. Sussman will be responsible for all clinical services and daily ...
... , PASO ROBLES, Calif., July 28 ... California, will make silicone micro-implants such as surgical drains, catheter ... not routine is the incredibly precise tolerances demanded of these ... achieving consistently precise results to within .001 inch is no ...
... , , New ... organizations , , WASHINGTON, July ... ability to show employers and purchasers that their on-going business ... help health care management companies achieve accreditation, URAC ...
... , MAITLAND, Fla. , July 28 ... treatment for infants with plagiocephaly and other head shape abnormalities, opened ... The Center currently also has offices in the Baltimore and Dallas ... orthoses, also commonly referred to as a cranial helmets or headbands. ...
... , , HOUSTON, July 28 ... finds that Houston Northwest Medical Center has received a Five-Star Rating ... for Bariatric Surgery in 2009/2010. , , HealthGrades ... American Hospitals Study, which analyzes patient outcomes for the most ...
... HARBIN, China, July 28 /PRNewswire-Asia-FirstCall/ -- China ... Company") (Nasdaq: CSKI ), a,leading fully integrated ... China ("PRC"), today announced that the,Company is scheduled to ... in early August, 2009. , ...
Cached Medicine News:Health News:CVS Caremark Names Andrew J. Sussman, M.D., as President/Chief Operating Officer of MinuteClinic 2Health News:CVS Caremark Names Andrew J. Sussman, M.D., as President/Chief Operating Officer of MinuteClinic 3Health News:When You Make Things That Get Implanted in People, Small Things Count 2Health News:URAC Launches New eLearning Courses for Health Care Management Accreditation 2Health News:URAC Launches New eLearning Courses for Health Care Management Accreditation 3Health News:URAC Launches New eLearning Courses for Health Care Management Accreditation 4Health News:New STAR Cranial Center of Excellence Offers Cutting-Edge Treatment to Central Florida Infants 2Health News:New STAR Cranial Center of Excellence Offers Cutting-Edge Treatment to Central Florida Infants 3Health News:New STAR Cranial Center of Excellence Offers Cutting-Edge Treatment to Central Florida Infants 4Health News:New STAR Cranial Center of Excellence Offers Cutting-Edge Treatment to Central Florida Infants 5Health News:Houston Northwest Medical Center's Bariatric Program Rated Top 15% in the Nation by HealthGrades 2Health News:Houston Northwest Medical Center's Bariatric Program Rated Top 15% in the Nation by HealthGrades 3Health News:China Sky One Medical, Inc. to Conduct Non-Deal Roadshow in Hong Kong and Singapore 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: