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Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement
Date:10/3/2008

er patients."

"The collaboration and license agreement with Lilly marks an important milestone in the growth and development of our company," said Daniel Flynn, President & CEO of Deciphera. "Lilly's strength in drug discovery and development, and in particular their commitment to cancer drug research, provides Deciphera with the opportunity to advance our B-Raf kinase 'switch pocket' inhibitors into the clinic and ultimately to patients in need of these therapies. We are very pleased to have Lilly as our partner in this endeavor."

About B-Raf Inhibitors

BRAF kinase is one of the most frequently mutated members of the kinase family across all cancers, and is particularly common in malignant melanomas, colon, and thyroid cancers. The V600E mutant form of BRAF kinase in particular has been associated with increased tumor aggressiveness and decreased survival rates in many types of cancers. Deciphera is pursuing two distinct strategies centered on BRAF inhibition. The first strategy seeks potent and highly selective BRAF inhibitors. The second strategy pursues BRAF inhibitors which also inhibit other kinases of interest.

About Deciphera

Deciphera Pharmaceuticals, LLC was established in 2003 as a drug discovery and development company with the mission to design, optimize and introduce "best-in-class" small molecule switch inhibitors of protein kinases for human clinical trials and the global pharmaceutical marketplace through the use of its proprietary drug discovery technology platform, Phylomechanics. Deciphera's kinase inhibitors target the mechanisms that render kinases oncogenic, retain potency against gatekeeper mutations, and afford selectivity profiles not easily attained by other approaches. For more information, visit the Company's website at http://www.deciphera.com.

About Lilly

Lilly, a leading innovation-driven corporation, is developing a growing portfolio
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SOURCE Eli Lilly and Company
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