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Lilly and Argonne National Laboratory Announce $2 Million Upgrade to Lilly's Beamline Capabilities
Date:7/14/2011

INDIANAPOLIS, July 14, 2011 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) and the U.S. Department of Energy's Argonne National Laboratory announced today the completion of Lilly's $2 million upgrade to the company's research-guided beamline, located at the Advanced Photon Source (APS) at Argonne's campus outside of Chicago. The APS is a U.S. Department of Energy Office of Science User Facility operated by Argonne.

The Lilly Research Laboratories Collaborative Access Team (LRL-CAT) beamline is a sophisticated x-ray analytical facility that produces detailed, atom-by-atom pictures of protein crystals. Its operations rely on the high-quality x-rays generated by the APS, one of the most powerful sources of x-rays for research purposes worldwide.

The data produced by the beamline and interpreted by LRL scientists provide valuable information on the interactions between potential new medicines and human disease protein targets. Lilly chemists, structural biologists, and the staff at the LRL-CAT beamline facility work together to create molecules, prepare crystals and analyze how the molecules bind to the proteins. The process is iterative, initially using beamline data to design new potential medicines with enhanced properties, which are in turn introduced into protein crystals and then re-analyzed.  

The LRL-CAT upgrade included an automation component that allows unattended operation of the beamline for extended periods. Previously, LRL-CAT employees worked in shifts on nights and weekends to maintain throughput. They can now monitor and, if necessary, operate the facility from remote locations using the Internet. The result is that Lilly scientists are able to get the data they need, as quickly as possible, in order to make informed decisions on the development of future Lilly medicines. The cost of the upgrade was
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