Navigation Links
Lilly Provides Update on Next Steps for Solanezumab
Date:12/12/2012

couraged and excited by the solanezumab data," said David Ricks, senior vice president and president, Lilly Bio-Medicines. "We are committed to working with the FDA and other regulatory authorities to bring solanezumab to the millions of patients and caregivers suffering from this devastating disease who urgently need this potential treatment."

About solanezumab
Solanezumab is a Phase 3, monoclonal antibody that binds to soluble monomeric forms of amyloid-beta after it is produced, allowing it to be cleared before it clumps together to form beta-amyloid plaques.

About the EXPEDITION Trials
The EXPEDITION trials consisted of two Phase 3, double-blind, placebo-controlled solanezumab trials in patients with mild-to-moderate Alzheimer's disease in 16 countries around the world. In both of the EXPEDITION study protocols, mild Alzheimer's disease was defined as a baseline Mini-Mental Status Examination (MMSE) score of 20 to 26 and moderate Alzheimer's disease was defined as a baseline MMSE score of 16 to 19.

The designs of EXPEDITION1 and EXPEDITION2 were the same. Patients aged 55 years or older were eligible to enroll in these studies; EXPEDITION1 enrolled 1,012 patients and EXPEDITION2 enrolled 1,040 patients. Patients received either 400mg of solanezumab infused intravenously (IV) or placebo every four weeks for approximately 18 months. Both EXPEDITION trials allowed patients to remain on stable standard of care (defined as their existing treatment regimen) during these studies. More than 85 percent of the patients in these trials were taking an acetycholinesterase inhibitor and / or memantine. 

While  primary endpoints, both cognitive and functional, were not met in the two Phase 3, double-blind, placebo-controlled solanezumab EXPEDITION trials in patients with mild-to-moderate Alzheimer's disease, a pre-specified secondary analysis of pooled data in patients with mild Alzheimer's disease showed a statistically significa
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Lilly to Expand Indianapolis Insulin Manufacturing Operations
2. Lilly Names Melissa Barnes Chief Ethics and Compliance Officer and Senior Vice President; Announces Retirement of Anne Nobles
3. Lilly Celebrates 18th Consecutive Year as One of Working Mothers 100 Best Companies
4. Boehringer Ingelheim and Lilly introduce the My Well Planner Lifestyle Improvement Program for Adults with Type 2 Diabetes
5. Lilly Announces Results From Lung Cancer Study
6. Lilly Announces Retirement of Robert Armitage, Names Michael Harrington Senior Vice President and General Counsel
7. Lilly Stops Phase III Development of Pomaglumetad Methionil For the Treatment of Schizophrenia Based on Efficacy Results
8. U.S. Court of Appeals Upholds Validity of Lillys Alimta Compound Patent
9. Lilly Revises 2012 Reported Guidance to Reflect Income from Early Payment of Amylin Obligations
10. Lilly Announces Study Results Regarding Postmenopausal Women with Back Pain Caused by Vertebral Fractures
11. Lilly Supports Research to Determine What a Dogs Nose Knows About People with Diabetes and Severe Hypoglycemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... new report released today from the Institute of Medicine ... training opportunities to reduce barriers to the provision of ... of CPR and AED use by bystanders remain less ... even though evidence indicates that its use ... strongly supports the IOM,s recommendation to encourage training through ...
(Date:6/30/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/54fkmt/global_array ... "Global Array Instruments Market 2015-2019" report to ... market to grow at a CAGR of 12.48 ... array instruments market can be divided into three ... tissue microarrays and cell microarrays. This report covers ...
(Date:6/30/2015)...  Today, the National Mobility Equipment Dealers Association (NMEDA) ... Awareness Month Local Heroes Contest on National TV. The ... received 1.3 million votes. The sponsors for the wheelchair ... , and Valley Honda Dealers , with the ... Mobility International (VMI) and ElDorado Mobility .  ...
Breaking Medicine Technology:New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 3New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 4Global Array Instruments Market 2015-2019 - Advances in Personalized Medicines with Affymetrix, Agilent Technologies & Illumina Dominating 2NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3
(Date:7/1/2015)... ... July 01, 2015 , ... Amada Senior Care, premier provider ... in the greater Phoenix area – their Mesa, Arizona location . Amada franchise ... with their purchase of the rights to the area after years of experience in ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... healthcare providers, has been retained to lead a national chief executive officer ... executive search firms in the healthcare industry, B. E. Smith has recently placed ...
(Date:7/1/2015)... ... July 01, 2015 , ... Research published in the journal ... app to test eyesight was just as accurate as those from standard paper-based charts ... Tropical Medicine is responsible for the development of the test, which does not depend ...
(Date:7/1/2015)... ... , ... The Recovery Workforce Summit: 2015 PRA Annual Conference , presented ... Atlantic, as a keynote on June 2nd in Philadelphia, PA. Stossel led a timely ... added power and reach to the essential message, while opening doors to wellness and ...
(Date:7/1/2015)... ... July 01, 2015 , ... These listings will give families ... sober companionship and delivery to wilderness therapy or treatment facilities. Therapeutic Experts ... with anxiety, ADHD, autism spectrum disorders, eating disorders, severe learning disabilities, addiction treatment, ...
Breaking Medicine News(10 mins):Health News:Amada Senior Care Expands to Greater Phoenix Area 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 3Health News:New Research Shows Reliability of Peek Eye Testing Mobile App 2Health News:New Research Shows Reliability of Peek Eye Testing Mobile App 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 2Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 4Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 5Health News:All Kinds of Therapy – Announces New Partnership Feature, Therapeutic Experts 2
... Pediatric patients, primarily those who are underinsured (either ... psychiatric care in hospital emergency departments (EDs), according ... the American Academy of Pediatrics (AAP) National Conference ... data, including patient age, sex, race, ethnicity, insurance ...
... the Internet to learn about pediatric health problems, little ... information, and how they use it prior to seeking ... by Parents Prior to Seeking Care at a Pediatric ... Academy of Pediatrics (AAP) National Conference and Exhibition (NCE) ...
... die from cancer It is known that the unmarried ... counterparts and there is some indication that the divide is ... open access journal BMC Public Health looks at ... and show that the difference in mortality between the married ...
... THURSDAY, Oct. 13 (HealthDay News) -- The stress associated with ... researchers say. The finding could help explain why certain ... other age-related conditions, according to a study published in ... This study may be the first to find a possible ...
... Smoky, inefficient indoor cooking and heating stoves that are widely ... deaths a year, according to health experts. Indoor air ... nearly half the world,s population, the U.S. National Institutes of ... current issue of the journal Science . The ...
... , THURSDAY, Oct. 13 (HealthDay News) -- Every afternoon ... gear, water bottles and lawn chairs converge on America,s ... much everyone agrees that the nation,s kids are in ... sports can help achieve that. Yet, some experts warn ...
Cached Medicine News:Health News:Parents who go online for pediatric health information are open to doctors' website recommendations 2Health News:Could Discrimination Help Trigger Illness in Blacks? 2Health News:Globally, 2 Million Deaths a Year Linked to Smoky Stoves 2Health News:Overzealous Parents, Coaches Take the Fun From Kids' Sports 2Health News:Overzealous Parents, Coaches Take the Fun From Kids' Sports 3Health News:Overzealous Parents, Coaches Take the Fun From Kids' Sports 4
Full Handle Laseredge Slit Blade Knife, 2.85 mm angled bevel up. Blade tip dimension: 14.4 mm x 2.8 mm x 3.7 mm....
Full Handle Laseredge Slit Blade Knife, 2.8 mm angled double bevel. Blade tip dimension: N/A x 2.8 mm x N/A....
Full Handle Laseredge Slit Blade Knife, 2.5 mm angled bevel up. Blade tip dimension: 14.4 mm x 2.5 mm x 3.7 mm....
Full Handle Laseredge Implant Blade Knife, 5.7 mm round tip. Blade dimension: 16.5 mm x 5.7 mm x 4.2 mm x 2.4 mm....
Medicine Products: