Navigation Links
Lilly Oncology Reveals Findings From Study of JAK2 Inhibitor for Blood Cancers at ASH Meeting
Date:12/12/2011

SAN DIEGO, Dec. 12, 2011 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced data from an oncology pipeline molecule today at the 53rd Annual Meeting of the American Society of Hematology (ASH). At the meeting, Lilly Oncology presented Phase I data from the investigational therapy LY2784544, a small-molecule Janus kinase 2 (JAK2) inhibitor, in development for the treatment of certain types of myeloproliferative neoplasms (MPNs), a group of blood cancers[1] characterized by abnormal production of red blood cells or myeloid cells (non-lymphocyte white blood cells).[2]

"Research into myeloproliferative neoplasms demonstrated the importance of the JAK2 genetic mutation as a target for potential treatment options," said Richard Gaynor, M.D., vice president of product development and medical affairs at Lilly Oncology. "These data show that our compound has the potential to inhibit the JAK2 mutation and should be studied further. We hope that this study is the first in Lilly's ongoing research and development of LY2784544 and that our findings signal a potential new treatment for patients fighting myeloproliferative neoplasms."

The Role of JAK2 in MPN

In 2005, researchers reported that a point mutation in the JAK2 gene occurs in more than 95 percent of patients with the MPN subtype polycythemia vera (PV) and the majority of patients with the subtypes myelofibrosis (MF) and essential thrombocythemia (ET).[2,3] The JAK2 point mutation observed in MPNs substitutes the amino acid phenylalanine for valine (at position 617 [V617F]) of the JAK2 protein.[2] The mutation makes JAK2 constantly active, triggering several signaling pathways that cause blood-forming cells to proliferate and resist apoptosis (programmed cell death).[4]  

Phase I Study Sought to Ascertain Safety, Tolerability

In pre-clinical study, LY2784544 selectively
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Katherine Baicker Elected to Lilly Board of Directors
2. Lilly for Better Health™ Expands Website to Include Spanish Health Information and Interactive Tools
3. The Zacks Analyst Blog Highlights: Pfizer, Bristol - Myers Squibb, Eli Lilly, Forest Laboratories and Abbott Laboratories
4. Eli Lilly and Company Named a Top Global Company for Leaders
5. Lilly Provides Additional Funding to Infectious Disease Research Institute to Identify New Tuberculosis Therapies
6. Lilly CEO Lechleiter Outlines Opportunities for Improved Health and Economic Growth in Asia-Pacific Region
7. Lilly and Amylin Mutually Agree to End Diabetes Alliance and Transition Exenatide Responsibility to Amylin
8. Lilly CEO Says Appropriate Assessment of Both Benefits and Risks Critical in Regulatory Process
9. Lilly Foundation Commits US $30 Million to The Lilly MDR-TB Partnership
10. Lilly Provides Update on 2011 Financial Guidance Due to Xigris Withdrawal
11. Prasco® Selected as Eli Lilly and Companys Authorized Generics Partner
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... , May 22, 2015 AcelRx Pharmaceuticals, Inc. ... on the development and commercialization of innovative therapies for ... that interim chief executive officer Howie Rosen ... chief financial officer Tim Morris will be ... the two presentations are as follows: Jefferies ...
(Date:5/21/2015)... 21, 2015 Research ... the addition of the "North American ... Digit Replacement, Elbow Replacement, Hip Replacement, Knee ... report to their offering. ,     (Logo: ... was valued at $4,470.9 million in 2014 ...
(Date:5/21/2015)... Research and Markets ( ... "North American Active Wound Care Market by ... & Ulcer), by End-User (In-Patient, & Out-Paient) - ... their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The North ... grow at a CAGR of 3.1% from 2014 ...
Breaking Medicine Technology:AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2
... SOUTH SAN FRANCISCO, Calif. , July 8 ... patient-derived induced pluripotent stem cells (iPSCs) for drug discovery, ... Series B equity financing.  The financing round was ... by Mitsubishi UFJ Capital and ATEL Ventures.  All current ...
... DALLAS , July 8, 2010 ... , Russia , India and China ) ... total BRIC patient monitoring devices,market is expected to be worth ... expected to account for nearly 62.9% of the total revenues. The ...
Cached Medicine Technology:iPierian Closes $22 Million Series B Financing Led By Google Ventures 2iPierian Closes $22 Million Series B Financing Led By Google Ventures 3New Report Patient Monitoring Emerging Markets (BRIC - Brazil, Russia, India and China) 2010 - 2014 Published by MarketsandMarkets 2New Report Patient Monitoring Emerging Markets (BRIC - Brazil, Russia, India and China) 2010 - 2014 Published by MarketsandMarkets 3
(Date:5/25/2015)... Decora Preset 60 Minute Countdown Timer , a ... Hardware City.’ The product helps in automatically switching off any ... the related electronic device is automatically turned off after the ... said, “We are glad that this amazing product is now ... Timer Switch in just a few clicks. The product has ...
(Date:5/24/2015)... Orion, Clarkston, Metamora, Michigan (PRWEB) May 24, 2015 ... which will allow them to take pressure measurements in ... bladder function. The doctor usually orders it if they ... overactive bladder (OAB). , Women’s Excellence in ... have problems with unwanted urinary leakage or problems with ...
(Date:5/24/2015)... Indiana Fiber Network, LLC (IFN), the leading Indiana ... Inc. (MTA) has selected IFN as a fiber transport ... Sales Manager, fiber route diversity and network redundancy are ... MTA with the diverse fiber transport from their Merrillville ... voice carriers located at Henry Street in Indianapolis, IN. ...
(Date:5/23/2015)... 23, 2015 On May 13, Nithyananda ... a youngster's yogic power learned through meditation and initiation ... in Bangalore, India. , Yogamaatha, a nine-year-old girl from ... high profile professionals attending the 2015 Business Advocacy Summit ... -- blindfolded. , In a demonstration that lasted ...
(Date:5/23/2015)... Manufacturers are now required to produce water heaters with ... in the field agree that the regulation is aimed at ... is what miles per gallon is to your car. The ... minimum HSPF score has been raised to 8.2, technology has ... of 12. Indeed, the regulation was welcomed by environmentalist, and ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2
... , ... ... ... ...
... , ... ... , , ... ...
... , ... ... ... ...
... The University of Texas M. D. Anderson Cancer Center, researchers ... early-stage bladder cancer, is a cost-effective method of detecting tumors. ... as well as the number of false positives that may ... The study was presented today in advance of the ...
... The Role of CBOs and NGOs in Global ... Paul Gaist, PhD, MPH, adjunct professor at the ... explores the pursuits and potential of community-based organizations ... public health. "At a time of unprecedented ...
... makes a difference, researchers say , WEDNESDAY, March 3 (HealthDay ... reducing the risk of type 2 diabetes, but whole grains ... show. , U.S. researchers analyzed data from 39,765 men in ... Nurses, Health Study I and II. None of the participants ...
Cached Medicine News:Health News:Osteotech to Present at the Canaccord Adams Musculoskeletal Conference 2Health News:Osteotech to Present at the Canaccord Adams Musculoskeletal Conference 3Health News:Complex New Guidelines From Multiple Organizations Confuses Men About Prostate Cancer Screening 2Health News:Complex New Guidelines From Multiple Organizations Confuses Men About Prostate Cancer Screening 3Health News:Complex New Guidelines From Multiple Organizations Confuses Men About Prostate Cancer Screening 4Health News:Complex New Guidelines From Multiple Organizations Confuses Men About Prostate Cancer Screening 5Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 2Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 3Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 4Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 5Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 6Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 7Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 8Health News:Virtual Dental Home to Provide Care to Underserved Communities in California 9Health News:Costly tests may not help detect bladder cancer recurrence, M. D. Anderson study finds 2Health News:'Igniting the Power of Community: The Role of CBOs and NGOs in Global Public Health' 2Health News:Whole Grains Take a Bite Out of Type 2 Diabetes Risk 2
... The total ergonomic solution and ... pipetting!, Soft, feather touch action and ... and strain, Stress-free tip ejection with ... for easy volume identification, Accepts universal ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... ejection with long, lever tip ejector, Color ... tips or for greater performance use Hamilton ...
... The BD Lancet Device offers the ease and ... than 90 percent of users in clinical trials ... easy to use., ,Six depth settings allow you ... smooth loading and unloading of lancets, the device ...
An automatic system for determining erythrocyte sedimentation rate (ESR) in EDTA tube and using cell counter racks....
Medicine Products: