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Lilly Diabetes Presents Phase II Blood Pressure and Heart Rate Data on Investigational GLP-1 Analog Candidate, Dulaglutide, in Patients with Type 2 Diabetes at the 27th American Society of Hypertension Scientific Meeting
Date:5/22/2012

NEW YORK, May 22, 2012 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced that dulaglutide, its investigational, long-acting glucagon-like peptide 1 (GLP-1) analog being studied as a once-weekly treatment for type 2 diabetes, met its primary endpoint of non-inferiority for mean 24-hour systolic blood pressure (SBP, or pressure while the heart contracts) after 16 weeks. The results came from a Phase II study that compared two doses of dulaglutide to placebo, using ambulatory blood pressure monitoring (ABPM) to characterize changes in blood pressure and heart rate. In addition, the 1.5 mg dulaglutide dose significantly reduced mean 24-hour SBP compared to placebo. These data were presented during a late-breaking clinical trial session at the 2012 Annual Scientific Meeting of the American Society of Hypertension (ASH) in New York.  

"Cardiologists and hypertension specialists are increasingly involved with evaluating the cardiovascular effects of diabetes medications," said Keith C. Ferdinand, M.D., FACC, FAHA, FASH, professor of clinical medicine, Section of Cardiology, Tulane University School of Medicine. "This study used the gold standard measurement technique of ABPM to evaluate the blood pressure and heart rate effects of dulaglutide, an investigational GLP-1 receptor agonist."

ABPM is a non-invasive, fully automated technique to measure blood pressure at specific intervals (usually every 15-30 minutes) throughout an entire 24-hour period. This approach allows clinicians to more accurately characterize a person's blood pressure levels throughout a normal day.

"We are very encouraged by these clinical trial results, in addition to the rest of the clinical trial data we've seen to date for dulaglutide," said Gwen Krivi, Ph.D., vice president, product development, Lilly Diabetes. "Dulaglutide is currently in Phase III clinical trials, wh
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