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Lilly Announces Review of Data on Long-Term Raloxifene Treatment for Postmenopausal Osteoporosis Published in Current Medical Research & Opinion
Date:8/9/2011

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"Lilly is committed to providing information regarding our therapies to help healthcare professionals and their patients engage in more informed discussions about available treatment options for postmenopausal osteoporosis," said co-author John Krege, M.D., medical fellow, Eli Lilly and Company.

About the Review"Long-term Raloxifene for Postmenopausal Osteoporosis" is a literature review of available information concerning EVISTA use for greater than three years for the treatment of postmenopausal osteoporosis and invasive breast cancer risk reduction in postmenopausal women with osteoporosis. Two reviewed studies were the Multiple Outcomes of Raloxifene Evaluation (MORE) trial and the Continued Outcomes of Raloxifene Evaluation (CORE) trial. The review includes summaries of previously published information, as well as a number of previously unpublished observations from analyses of the clinical study databases. In addition, new data from three patients who underwent iliac crest bone biopsies after eight years of EVISTA therapy were reported.

About EVISTA® (raloxifene HCl tablets)EVISTA is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM), which appears to act like estrogen in bone and to block the effects of estrogen in some tissues. It is an osteoporosis therapy for postmenopausal women that also reduces the risk of invasive breast cancer in postmenopausal women with osteoporosis.

EVISTA is approved by the U.S. Food and Drug Administration (FDA) for the treatment and prevention of osteoporosis in postmenopausal women.  EVISTA is also indicated for the reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis. There are Important Limitations of Use for breast cancer risk reduction:

  • There are no data available regarding the effect of EVISTA on invasive breast cancer incidence in women with inherited mutations
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  • SOURCE Eli Lilly and Company
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