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Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimer's Disease Compound
Date:10/1/2008

nition (ADAS-cog), which measures cognitive function with an emphasis on memory, and the Alzheimer's Disease Cooperative Study - Activities of Daily Living scale (ADCS-ADL), which measures the ability to independently perform daily activities such as eating, bathing, and using the telephone. A number of optional biomarker substudies will be available to patients that will utilize brain-scanning and biochemical techniques to detect markers of Alzheimer's disease.

Alzheimer's disease is a progressive neurodegenerative condition that is the most common cause of dementia, accounting for 60 to 80 percent of cases(1). Estimates show that 6-8 percent of people over age 65 are affected by Alzheimer's disease(2), totaling approximately 5.5 million people in the United States alone(3). Every 72 seconds, an American is developing Alzheimer's disease(4), and it is the seventh-leading cause of death in the United States(5). The direct and indirect health care costs associated with Alzheimer's disease and other dementias in the U.S. are estimated to be about $150 billion(6). In 2005, the total cost worldwide of dementia, of which Alzheimer's disease is the most common cause, was estimated at $315.4 billion(7). The burden to caregivers and health care costs can increase dramatically in the late stages of Alzheimer's disease, when patients cannot maintain independent function and are frequently bedridden(8).

About LY450139

LY450139 inhibits gamma secretase, an enzyme that cuts a protein, creating a shorter, sticky protein called amyloid beta. Alzheimer's disease theory suggests that some subtypes of amyloid beta clump together and eventually kill brain cells. Clinical studies have examined the effect of LY450139 on amyloid beta in blood and cerebrospinal fluid. The most frequently occurring side effects experienced in earlier clinical studies with LY450139 include diarrhea, upset stomach, and fatigue. For a more complete listing of potential side effects, prosp
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SOURCE Eli Lilly and Company
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