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Lilly, Kowa and Kowa Pharmaceuticals America Announce Co-Promotion and Licensing Agreement
Date:12/23/2009

st deal with potential interactions with other medications. LIVALO offers a new statin option, with LDL lowering consistent with the commonly administered doses of Lipitor® and Zocor®, and significantly greater LDL lowering in the elderly compared to Pravachol®," stated LeRoy LeNarz, M.D., senior medical director at Lilly.

"It is with great pleasure that we partner with an internationally-renowned company like Lilly," said Yoshihiro Miwa, Kowa president and CEO. "With a joint effort by Lilly, Kowa and Kowa Pharmaceuticals America, we hope to pave the way for the efficient market entry and establish a presence with LIVALO in the statin market in the U.S. and Latin America."

"We are excited to partner with Lilly as we work to establish the LIVALO brand and expand Kowa Pharmaceuticals America's presence in the U.S. market," said Ben Stakely, president and CEO of Kowa Pharmaceuticals America.

About LIVALO

LIVALO is a fully synthetic statin originating from Japan. The efficacy of LIVALO has been evaluated against atorvastatin, simvastatin, and pravastatin in patients with primary hyperlipidemia or mixed dyslipidemia. In these studies, LIVALO effectively reduced LDL-C, including in patients with diabetes, the elderly, and patients with 2 or more risk factors for coronary artery disease. Unlike many statins, LIVALO is only minimally metabolized by the liver Cytochrome P450 enzyme system, suggesting that the potential for clinically significant drug interactions between LIVALO and drugs that inhibit or that are metabolized by CYP450 enzymes, including warfarin, would be reduced.

Since its launch in Japan, South Korea, Thailand and China, LIVALO has been successfully used in these countries to treat hypercholesterolemia and familial hypercholesterolemia, and has accumulated millions of patient-years of exposure. In Japan, sales of LIVALO for fiscal year 2008 reached 34 billion yen (approximat
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SOURCE Eli Lilly and Company
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