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Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium
Date:11/7/2007

irin alone. The primary endpoint in the study was the inhibition of TXB2, measured through blood samples that were collected after the first five days of the study and again on day 11. The mean (+/- SD) degree of serum TXB2 inhibition was:

-- 99.7% (+/- 0.26%) for 81 mg of enteric-coated, low-dose aspirin once

daily

-- 99.7% (+/- 0.26%) for 81 mg of enteric-coated, low-dose aspirin once

daily plus naproxen 220 mg three times daily

-- 99.6% (+/- 0.45%) for 81 mg of enteric-coated, low-dose aspirin once

daily plus 1,000 mg of acetaminophen four times daily

An exploratory endpoint in which researchers evaluated thromboxane inhibition of those who discontinued naproxen sodium but continued to receive 81 mg of enteric-coated low-dose aspirin requires additional evaluation before conclusions can be drawn.

"These data, confirming that the OTC dose of naproxen sodium did not interfere with daily doses of 81 mg aspirin, add to the significant body of evidence that support the cardiovascular safety of naproxen," said study author Marc C. Hochberg, M.D., M.P.H., Professor of Medicine and Head of the Rheumatology and Clinical Immunology Division, University of Maryland School of Medicine.

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SOURCE Bayer Consumer Care
Copyright©2007 PR Newswire.
All rights reserved

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