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Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium
Date:11/7/2007

en (1,000 mg qid) on the antiplatelet effect when administered together with low-dose aspirin therapy (81mg). Acetaminophen was used as a comparator as previous research has confirmed that it does not alter the platelet inhibition of low dose aspirin therapy. This clinical study did not measure the degree of molecular interaction, but the findings suggest that those on aspirin therapy can safely take OTC naproxen without compromising the intended cardiovascular benefit of aspirin. The findings will be presented via poster presentation on Friday, November 9.

These results are consistent with previous findings on the prescription dose of naproxen. Results of a previous study indicated that the prescription strength dose of naproxen (500mg bid)(1) administered two hours before or after low-dose aspirin did not interfere with the antiplatelet effects.

Methodology and Findings

This study was a single-center, randomized, open-label, 3-period trial with an intent-to-treat (ITT) population of 45 healthy men and women. Thirty seven participants who met the study criteria were given 81 mg of enteric- coated, low-dose aspirin once daily. After the first five days, all subjects demonstrated a 99 percent level of thromboxane (TXB2) inhibition.

The group was then divided into three groups for an additional five days of treatment:

-- The first group [n=12] continued on 81 mg of enteric-coated, low-dose

aspirin once daily;

-- The second group [n=12] were given 81 mg of enteric-coated, low-dose

aspirin once daily plus naproxen 220 mg three times daily; and

-- The third and final group [n=13] were given 81 mg of enteric-coated,

low-dose aspirin once daily plus 1,000 mg of acetaminophen four times

daily.

After the second round of treatment, all arms showed a 99% or higher thromboxane inhibition, supporting the conclusion that naproxen sodium does not change the antiplatelet effect profile seen with asp
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SOURCE Bayer Consumer Care
Copyright©2007 PR Newswire.
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