Navigation Links
Lifelong Antiretroviral Treatment for HIV-Infected Pregnant Women Prevents Infection in Children, Saves Mothers' Lives, Study Finds
Date:3/12/2013

BETHESDA, Md., March 12, 2013 /PRNewswire/ -- Providing life-long antiretroviral treatment to HIV-infected pregnant women not only prevents HIV infections in infants, but also improves the 10-year survival rate in mothers, saving more than 250,000 maternal life years and reducing the likelihood that children born to these mothers will become orphans, a study published today in the journal PLOS ONE found.

Transmission of HIV during pregnancy, labor, delivery or breastfeeding is the main mode of HIV infection in children. An estimated 390,000 children worldwide acquired HIV from their mothers in 2010, with more than 90 percent of these new infections occurring in sub-Saharan Africa. Malawi, a low-income country of 15 million people, is one of the countries with the highest number of HIV-infected pregnant women.

The study from Abt Associates' Dr. Carlos Avila and colleagues examined how the Ministry of Health in Malawi is implementing a new program termed Option B+, in which all pregnant women who test HIV positive are placed on antiretroviral therapy (ART) for life, regardless of their CD4 count or clinical stage.

They looked at whether the program represents a cost-effective policy option for treating HIV-infected pregnant women and for preventing mother-to-child transmission, as compared with World Health Organization guidelines (Option A and B) to prevent mother-to-child transmission of HIV. Those guidelines recommend antiretroviral therapy for women with CD4 counts at or lower than 350 cells per microliter, which presents a major restriction in areas where lab resources are scarce. Under WHO Option A, the mother receives antiretrovirals at three different stages of pregnancy and then for a week after childbirth. Under WHO Option B, the mother takes a triple antiretroviral regimen at 14 weeks, and continues taking this treatment until the child is born. Antiretrovirals are suspended after delivery, or one week after all infant exposure to breast milk has ended. The infants receive antiretroviral prophylaxis.

Researchers used data from Malawi to simulate the progression of HIV among a group of HIV-infected pregnant women who received preventive and antiretroviral therapy, and estimated the number of pediatric infections averted and maternal life years gained over a 10-year period. They found that providing lifelong antiretroviral treatment to all mothers would improve 10-year survival in mothers more than four-fold, saving more than 250,000 maternal life years, as compared to mothers receiving other treatment options, which saved 153,000 and 172,000 life years respectively. In addition, providing ARTs for all HIV-infected pregnant women could save $455 U.S. per life year gained.

"Although providing these drugs may cost more in the short term, it will save many lives, prevent future infant infections and reduce the chances that a child will become an orphan in the long term," said Avila, a senior health economist at Abt. "This study takes into account the realities of providing antiretrovirals in rural Africa, where lab facilities are scarce and requirements to start treatment based on CD4 counts are a major impediment to mothers getting the treatment they need."

The researchers also note that simplifying drug regimen options may improve adherence to therapy and can help overcome some of the individual, organizational and societal barriers to achieving high coverage levels of prophylaxis and treatment.

For the full paper, please visit: http://dx.plos.org/10.1371/journal.pone.0057778

About Abt Associates
Abt Associates is a mission-driven, global leader in research and program implementation in the fields of health, social and environmental policy, and international development. Known for its rigorous approach to solving complex challenges, Abt Associates is regularly ranked as one of the top 20 global research firms and one of the top 40 international development innovators. The company has multiple offices in the U.S. and program offices in nearly 40 countries. www.abtassociates.com


'/>"/>
SOURCE Abt Associates
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Mylan Launches Innovative Portfolio of Antiretroviral Products for Treatment of HIV/AIDS in South Africa
2. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
3. Aethlon Medical Note: An Unprecedented Data Point, The Single-Treatment Capture of Hepatitis C Virus (HCV) by the Aethlon Hemopurifier®
4. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
5. Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
6. Elekta, pioneer in treatment of cancer in brain disorders, to Move North America Headquarters to Atlanta
7. Ampio Awarded US and Canadian Patents that will Bolster the Commercialization of Optina™ for the treatment of Diabetic Macular Edema (DME)
8. National Patient Advocate Foundation Praises Signing of the Delaware Cancer Treatment Access Act into Law
9. Zogenix Submits New Drug Application (NDA) to U.S. Food and Drug Administration (FDA) for Zohydro™ for Treatment of Chronic Pain
10. Janssen Research & Development Submits XARELTO® (rivaroxaban) to U.S. FDA for the Treatment and Prevention of Recurrent Venous Thromboembolism
11. Study Results Demonstrate Analytical Treatment Interruption to Assess Antiviral Activity of Argoss Arcelis™ Personalized Immunotherapy for Treatment of HIV Patients, AGS-004, Is Acceptable Strategy for At Least 16 Weeks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):