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Life Technologies Signs Agreement with GlaxoSmithKline Biologicals S.A., Seeking Expanded Use of Platform Technologies into Companion Diagnostics
Date:10/25/2011

CARLSBAD, Calif., Oct. 25, 2011 /PRNewswire/ -- Life Technologies Corporation (NASDAQ: LIFE) today announced that the company has signed an agreement with GlaxoSmithKline Biologicals S.A. (GSK) to develop a diagnostic to be used as a companion test with a GSK candidate cancer immunotherapy. Specifically, Life will develop a qPCR-based molecular diagnostic assay for GSK's MAGE-A3 cancer immunotherapy candidate designed to identify patients likely to benefit from the immunotherapy.

MAGE-A3 candidate immunotherapy is currently being evaluated in two clinical trials. The phase III clinical study MAGRIT, the largest lung cancer treatment study ever conducted, is evaluating its efficacy and safety as an adjuvant treatment in resected non-small cell lung cancer.  The Phase III clinical study DERMA is evaluating the efficacy and safety of the MAGE-A3 candidate immunotherapy as an adjuvant treatment in patients whose melanoma invaded lymph nodes.

Life's companion assay will be a multi-gene expression qPCR-based in vitro diagnostic assay designed to act as an aid in the assessment of patients who are more likely to benefit from treatment with MAGE-A3 candidate cancer immunotherapy.

"Life Technologies' platform technologies, such as qPCR, are allowing biological knowledge to be applied in multiple markets, including companion diagnostics," said Kim Caple, head of molecular diagnostics at Life Technologies.  "We are excited to partner with GSK to demonstrate how using genetic analysis may further help select patients likely to benefit from such a treatment approach."

Life's companion diagnostic will be developed utilizing the company's robust Taqman® Array Card (TAC) technology which is easy to use and is currently an ideal fit for researchers looking to assay panels of genes. It is not available or inten
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SOURCE Life Technologies Corporation
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