Navigation Links
Life Technologies Launches GeneArt® Precision TALs

CARLSBAD, Calif., March 19, 2012 /PRNewswire/ -- Life Technologies Corporation (NASDAQ: LIFE) today announced the launch of GeneArt® Precision TALs, generally referred to as TAL effector proteins (TALE), which will allow researchers the ability to edit genomes and control gene activity with unprecedented precision and reliability.


"We expect the GeneArt® TAL launch to be enthusiastically welcomed by the scientific community," said Nathan Wood, vice president of synthetic biology at Life Technologies. "These tools will empower our customers to carry out experiments on their 'wish lists' that they cannot readily do with existing technologies."

The development of TAL effector proteins has been closely watched by synthetic biologists, who plan to utilize them in research to develop solutions for better healthcare, agriculture and energy. Specific applications range from design of disease and drug efficacy models for the pharmaceutical industry to human gene therapy, a field that has been plagued by safety concerns due to random insertion of introduced genes and vectors into the genome.

TAL effectors can be designed to bind to specific DNA sequences selected by researchers and can deliver a variety of functional elements to activate or repress gene expression or to cut and insert DNA with precision. TAL proteins have an advantage over competing zinc finger technology in that they are simpler to design, bind with greater specificity, displaying fewer "off-target" events.

TAL effectors were originally discovered in bacteria that infect plants, where they target specific DNA sequences in the plant genome, rewiring gene expression to establish and propagate infection.  The simple TAL effector translation code allows researchers to specifically design TAL binding proteins to bind to a DNA sequence of choice. 

"Researchers give us the sequence they want to target, and we send them a gene encoding the TAL protein that will target it," said Wood. "The encoding process is that simple."

"TAL effectors have been evolved with beautiful simplicity," said Jens Boch, co-inventor of TAL technology. "We can now harness their natural properties to make a unique tool that represents a giant leap for genome editing and other applications."

GeneArt® Precision TALs are supplied as Gateway® compatible entry clones encoding a DNA binding protein for a specific customer-submitted sequence fused to a range of customer selected effector domains. Custom TALs will typically be delivered in 3 weeks after orders are placed.

The current offering includes TALs fused with gene activators, endonucleases or a vector with multiple cloning sites providing customers the ability to link their own functional domain proteins to the TAL protein, constituting a system that is easily customized to each researcher's needs. A TAL offering with a gene repression domain will be released at a future date.

The TAL Effector Technology license was jointly signed with inventors Boch, Ulla Bonas, Thomas Lahaye and Sebastian Schornack based from seminal discovery work while at Martin-Luther-Universitat Halle-Wittenberg, and with Two Blades Foundation (2Blades), which exclusively licensed plant research tool uses to Life Technologies and retains exclusive rights for commercial applications in plants.

For more information, please visit

All products referenced are for Research Use Only. Not intended for diagnostic uses.

About Life Technologies
Life Technologies Corporation (NASDAQ: LIFE) is a global biotechnology company with customers in more than 160 countries using its innovative solutions to solve some of today's most difficult scientific challenges. Quality and innovation are accessible to every lab with its reliable and easy-to-use solutions spanning the biological spectrum with more than 50,000 products for translational research, molecular medicine and diagnostics, stem cell-based therapies, forensics, food safety and animal health. Its systems, reagents and consumables represent some of the most cited brands in scientific research including: Ion Torrent™, Applied Biosystems®,  Invitrogen™, GIBCO®, Ambion®, Molecular Probes®, Novex®, and TaqMan®. Life Technologies employs approximately 10,400 people and upholds its ongoing commitment to innovation with more than 4,000 patents and exclusive licenses. LIFE had sales of $3.7 billion in 2011. Visit us at our website:

Life Technologies' Safe Harbor Statement
This press release includes forward-looking statements about Life Technologies' anticipated results that involve risks and uncertainties. Some of the information contained in this press release, including, but not limited to, statements as to industry trends and Life Technologies' plans, objectives, expectations and strategy for its business, contains forward-looking statements that are subject to risks and uncertainties that could cause actual results or events to differ materially from those expressed or implied by such forward-looking statements. Any statements that are not statements of historical fact are forward-looking statements. When used, the words "believe," "plan," "intend," "anticipate," "target," "estimate," "expect" and the like, and/or future tense or conditional constructions ("will," "may," "could," "should," etc.), or similar expressions, identify certain of these forward-looking statements. Important factors which could cause actual results to differ materially from those in the forward-looking statements are detailed in filings made by Life Technologies with the Securities and Exchange Commission. Life Technologies undertakes no obligation to update or revise any such forward-looking statements to reflect subsequent events or circumstances.


Life Technologies Contact
Suzanne Clancy
760-717-8294 (mobile)

SOURCE Life Technologies Corporation
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
2. King Pharmaceuticals and Palatin Technologies Delay Immediate Plans for Phase 3 Clinical Program With Bremelanotide for Erectile Dysfunction
3. Rockwell Medical Technologies, Inc. Begins Patient Enrollment for its SFP Dose-Ranging Study
4. Rockwell Medical Technologies, Inc. Begins Dosing Patients for SFP Phase IIb Clinical Study
5. New Clinical Studies Confirm Mauna Kea Technologies Cellvizio(R) GI in Range of Procedures
6. Palatin Technologies, Inc. Reports Initiation of Human Trials for the Treatment of Congestive Heart Failure
7. Emisphere Technologies, Inc. Announces 2007 Third Quarter Financial Results
8. Senesco Technologies Initiates Preclinical Studies for Cancer Target
9. ASEAN News: Epeius Biotechnologies Gains Commercial Approval for Rexin-G(R), a Tumor-Targeted Gene-Based Medicine for Metastatic Cancer
10. Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine
11. TCS Healthcare Technologies Releases Three New Clinical Care Programs Within ACUITY
Post Your Comments:
(Date:10/11/2017)... FRISCO, Texas , Oct. 11, 2017 /PRNewswire/ ... healthcare services, has amplified its effort during National ... patients about hereditary cancer risks. ... Journal of Clinical Oncology calculated that more than ... to have inherited mutations in BRCA1 or BRCA2 and ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
Breaking Medicine Technology:
(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
Breaking Medicine News(10 mins):