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Life Technologies Launches GeneArt® Precision TALs
Date:3/19/2012

CARLSBAD, Calif., March 19, 2012 /PRNewswire/ -- Life Technologies Corporation (NASDAQ: LIFE) today announced the launch of GeneArt® Precision TALs, generally referred to as TAL effector proteins (TALE), which will allow researchers the ability to edit genomes and control gene activity with unprecedented precision and reliability.

(Photo: http://photos.prnewswire.com/prnh/20120319/LA71858)

"We expect the GeneArt® TAL launch to be enthusiastically welcomed by the scientific community," said Nathan Wood, vice president of synthetic biology at Life Technologies. "These tools will empower our customers to carry out experiments on their 'wish lists' that they cannot readily do with existing technologies."

The development of TAL effector proteins has been closely watched by synthetic biologists, who plan to utilize them in research to develop solutions for better healthcare, agriculture and energy. Specific applications range from design of disease and drug efficacy models for the pharmaceutical industry to human gene therapy, a field that has been plagued by safety concerns due to random insertion of introduced genes and vectors into the genome.

TAL effectors can be designed to bind to specific DNA sequences selected by researchers and can deliver a variety of functional elements to activate or repress gene expression or to cut and insert DNA with precision. TAL proteins have an advantage over competing zinc finger technology in that they are simpler to design, bind with greater specificity, displaying fewer "off-target" events.

TAL effectors were originally discovered in bacteria that infect plants, where they target specific DNA sequences in the plant genome, rewiring gene expression to establish and propagate infection.  The
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SOURCE Life Technologies Corporation
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