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Life Technologies Enters into an Exclusive License and Supply Agreement for Dynabeads
Date:7/31/2013

lete responses with one ongoing in two children with leukemia3.

The personalized therapy consists of removing blood cells from cancer patients; isolating  and activating T cells; genetically modifying the T cells thereby programming those cells to recognize and attack cancer cells; expanding  the T cells; and, lastly, introducing those cells back into the body so the patient's immune system can take over. Under the terms of the current agreement, Life Technologies' Dynabeads® CD3/CD28 CTS™, will be used to isolate, activate and expand the T cells.

"Dynabeads ® CD3/CD28 CTS™ have unique properties that are ideal for producing a robust immunotherapeutic," said Oystein Aamellem, head of Cellular Medicine at Life Technologies. "Not only do the beads assure that T cells are separated from any unwanted cells, it also triggers the T cells to reproduce in a natural and controlled manner, ensuring a therapeutically relevant population is transferred back into the patient."

"The current agreement with Novartis represents a significant step in the growth of Life Technologies from a research tools provider to a leading medical device company," said Lucier. "We're very excited about the opportunity to work with Novartis to deliver novel therapeutics to fill a critical need in cancer care."

1Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia. Porter, David L., et. al.; N Engl J Med 2011; 365:725-733.

2T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia. Kalos, Michael, et. al.; Sci Transl Med 10 August 2011: Vol. 3, Issue 95, p. 95.

3Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. Grupp, Stephan A., et al.; N Engl J Med 2013; 368;1509-1518

Dynabeads® CD3/CD28 CTS™ are For Research
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