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Life Technologies Acquires Pinpoint Genomics and CLIA-Approved Lung Cancer Test
Date:7/25/2012

ntinues to group together in both stages I and II many patients who have been cured by surgery with patients who will recur and die.  As a result, many stage II patients forgo chemotherapy in the hope that they are in the former group; to date, there has been no validated method of identifying the highest-risk stage I patients for whom chemotherapy is recommended.

"Some patients who don't need them receive highly toxic chemotherapeutic drugs, while others die without receiving potentially life-saving intervention simply because their risk of progression couldn't be predicted," said David Jablons, M.D., chief of general thoracic surgery at the University of California, San Francisco, who helped co-found Pinpoint Genomics with Dr. Mann. "Physicians need molecular tools that accurately identify true high-risk patients."

Life Technologies to Offer Test through CLIA-Certified Laboratory

The Pinpoint Genomics' laboratory acquired by Life Technologies is the first to market an application that has been rigorously validated in large-scale, independent studies to reliably predict the risk of death for early-stage lung cancer patients.  The test was developed in Pinpoint's CLIA-certified environment and validated through two independent, blinded retrospective studies involving approximately 1,500 patients.  Using formalin-fixed, paraffin-embedded tumor specimens, this quantitative PCR lab-developed test (LDT) measures expression of a proprietary 14-gene panel. Results of the blinded studies, which demonstrated the test's clinical validity and utility, were published in the highly-regarded medical journal, The Lancet.1

"By ordering the Pinpoint test, doctors will be able to identify which patients have a high chance of death after surgery, so they can be aggressive and treat those patients immediately for disease and save lives," said Dr. Jablons.

Treating disease early is also likely to be economical as better uti
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SOURCE Life Technologies Corporation
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