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Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate

THE WOODLANDS, Texas, Aug. 13 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) today announced the company will be making an oral presentation at the American Chemical Society National Meeting and Exposition in Boston, Massachusetts on Tuesday, August 21, 2007 at 2:50 p.m. Eastern Time. The presentation, based on the paper titled, "Modulation of peripheral serotonin levels by enzyme inhibitors for the potential treatment of irritable bowel syndrome (IBS)," will reveal the target of Lexicon's clinical candidate, LX1031, a potential treatment for irritable bowel syndrome (IBS), which is currently being investigated in a Phase 1b clinical trial in healthy volunteers. The presentation is part of the Division of Medicinal Chemistry general oral session and the paper number is 235.

Lexicon will also present a separate poster titled, "Open access mass-directed purification: Adaptation to diverse loading scales and compound polarities," at the same conference on August 19, 2007. The paper number is 174 and will be included in the Division of Medicinal Chemistry poster session which begins at 7:00 p.m. Eastern Time.

About Lexicon

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has development programs underway for such areas of major unmet medical need as irritable bowel syndrome and cognitive disorders. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bristol-Myers Squibb Company, Genentech, Inc. and N.V. Organon. For additional information about Lexicon and its programs, please visit

Safe Harbor Statement

This press release contains "forward-looking statements," including statements relating to Lexicon's clinical development of LX1031 and the potential therapeutic and commercial potential of LX1031. This press release also contains forward-looking statements relating to Lexicon's growth and future operating results, discovery and development of products, strategic alliances and intellectual property, as well as other matters that are not historical facts or information. All forward-looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct clinical development of LX1031 and preclinical and clinical development of its other potential drug candidates, advance additional candidates into preclinical and clinical development, obtain necessary regulatory approvals, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as additional factors relating to manufacturing, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward-looking statements. Information identifying such important factors is contained under "Factors Affecting Forward-Looking Statements" and "Risk Factors" in Lexicon's annual report on Form 10-K for the year ended December 31, 2006, as filed with the Securities and Exchange Commission. Lexicon undertakes no obligation to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE Lexicon Pharmaceuticals, Inc.

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