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Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome
Date:10/15/2007

brain and GI tract, where it has distinctly different functions. In the brain, serotonin is associated with mood and behavior, whereas in the GI tract it stimulates motility and signals feelings of discomfort and nausea. The dysregulation of serotonin is thought to be associated with functional GI disorders, including IBS.

IBS is a functional bowel disorder of the GI tract characterized by changes in bowel habits that are not specifically associated with any particular disease. Symptoms include diarrhea, constipation, bloating, gas, abdominal pain, and cramping. As many as one in five American adults suffers from IBS, making it the most common disorder seen by gastroenterologists and one of the most common disorders seen by primary care physicians.

LX1031 is being developed in a product development collaboration with Symphony Capital Partners, L.P. and its co-investors.

About Lexicon

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has development programs underway for such areas of major unmet medical need as irritable bowel syndrome and cognitive disorders. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bristol-Myers Squibb Company, Genentech, Inc. and N.V. Organon. For additional information about Lexicon and its programs, please visit http://www.lexpharma.com.

Safe Harbor Statement

This press release contains "forward-looking statements," includi
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SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
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