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Lexicon Receives Funding for Phase 2 Clinical Trial of LX4211 in Type 1 Diabetes
Date:5/3/2012

uch as glucagon-like peptide-1 (GLP-1) that help regulate blood glucose levels. In addition, LX4211 enhances excretion of glucose in the urine, which may also help to reduce the need for insulin, without causing low blood sugar or hypoglycemia. Lexicon expects to have results from an ongoing Phase 2b trial in type 2 diabetes by mid-year 2012.

About the Clinical Trial in Type 1 Diabetes
The initial Phase 2 proof-of-concept study will be a randomized, double-blinded, placebo-controlled trial in approximately 25 adult patients with type 1 diabetes who will receive LX4211 over a one month treatment period. The primary endpoint of the study will be reduction of insulin required with LX4211 as compared to placebo. Secondary endpoints will include multiple measures of blood sugar to show that LX4211 helps to maintain glycemic control during the treatment period. Under the agreement, additional funding could support future Phase 2 trials of LX4211 in type 1 diabetes.

About Type 1 Diabetes
An estimated 1.3 million people in the U.S. have type 1 diabetes, a chronic disease usually caused by autoimmune destruction of insulin-producing beta cells of the pancreas. The resulting decrease in insulin leads to high levels of glucose in the blood, which in turn can lead to acute metabolic complications as well as chronic problems with eyes, kidneys, nervous system and heart. If not properly controlled with insulin therapy, type 1 diabetes can be fatal. Patients with type 1 diabetes are at least 10 times more at risk for cardiovascular disease compared to people without diabetes. The rate of type 1 diabetes incidence among children under the age of 14 is estimated to increase by 3% annually worldwide.

About Lexicon
Lexicon is a biopharmaceutical company focused on discovering breakthrough treatments for human disease. Lexicon currently has five drug programs in mid-stage development for diabetes, carcinoid syndrome, irrita
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SOURCE Lexicon Pharmaceuticals, Inc.
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