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Lexicon Presents Positive Outcome in IBS Patients Treated With LX1031 and Data Supporting Mechanism of Action
Date:5/5/2010

THE WOODLANDS, Texas, May 5 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease, presented results from its positive Phase 2 clinical study with LX1031 in patients with non-constipating irritable bowel syndrome (IBS) at Digestive Disease Week (DDW) 2010 in New Orleans, Louisiana.

LX1031 is an oral, serotonin synthesis inhibitor that acts locally in the gastrointestinal tract targeting tryptophan hydroxylase (TPH), an enzyme necessary for the production of serotonin. LX1031 is the first TPH inhibitor to be evaluated in human clinical trials for the treatment of IBS.  Results from the randomized, placebo-controlled study of 155 patients with non-constipating IBS showed that patients who received LX1031 (1,000 mg four times a day) for 28 days experienced significant improvement (p<0.05) in global assessment of relief of IBS pain and discomfort over the four-week dosing
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SOURCE Lexicon Pharmaceuticals, Inc.
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