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Lexicon Presents Data at the American Diabetes Association Meeting On Blood Pressure Reduction and Weight Loss In Clinical Trial of LX4211
Date:6/24/2013

treatment, a promising finding in regard to future development of LX4211."

Brian Zambrowicz, Ph.D., Lexicon's executive vice president and chief scientific officer, delivered an oral presentation titled "LX4211, a Dual SGLT1/SGLT2 Inhibitor, Decreases Body Weight and Triglycerides in Patients with Type 2 Diabetes Mellitus and Elevated Baseline Values."  This presentation highlighted the reductions in body weight and triglycerides by LX4211 for subgroups with varying body mass indexes (BMI) and triglyceride levels at baseline in the same Phase 2b study.  Patients with baseline BMI>30 treated with 200 mg once-daily, 200 mg twice-daily and 400 mg once-daily treatment all experienced greater average body weight reductions than placebo (p<0.001). Patients with high baseline triglycerides, between 200 and 500 mg/dL, experienced reductions with LX4211 treatment that were significantly larger than those experienced by patients with baseline triglycerides lower than 200 mg/dL in three of the four LX4211 doses tested.

All presentations will be available for download from Lexicon's corporate website www.lexpharma.com.

About Lexicon

Lexicon is a biopharmaceutical company focused on discovering breakthrough treatments for human disease.  Lexicon currently has multiple programs in clinical development for diabetes, irritable bowel syndrome, carcinoid syndrome and other indications, all of which were discovered by Lexicon's research team.  Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets.  Lexicon has focused drug discovery efforts on these biologically-validated targets to create its extensive pipeline of clinical and preclinical programs.  For additional information about Lexicon and its programs, please visit www.lexpharma.com.


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SOURCE Lexicon Pharmaceuticals, Inc.
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