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Lexicon Presents Data at the American Diabetes Association Meeting On Blood Pressure Reduction and Weight Loss In Clinical Trial of LX4211
Date:6/24/2013

THE WOODLANDS, Texas, June 24, 2013 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, delivered two oral and two poster presentations on LX4211 at the 73rd Scientific Sessions of the American Diabetes Association (ADA) in Chicago, on June 23, 2013.

Pablo Lapuerta, M.D., Lexicon's executive vice president, clinical development and chief medical officer, delivered an oral presentation titled "LX4211, a Dual Inhibitor of Sodium Glucose Transporters SGLT1 and SGLT2, Reduces Blood Pressure in Patients with Type 2 Diabetes."  This presentation highlighted the reductions in blood pressure by LX4211 for subgroups with varying blood pressures at baseline in a 12-week dose-ranging Phase 2b study of 299 patients with type 2 diabetes. Patients with high baseline systolic blood pressure (>130 mmHg) dosed with LX4211 experienced an average of 14 mmHg reduction in systolic blood pressure when compared to placebo (p=0.002). In contrast, patients with normal systolic blood pressure at baseline (<130 mmHg) experienced an average of 1 mmHg reduction (p=0.6). Systolic blood pressure readings below 100 mmHg, as well as orthostatic systolic blood pressure changes (changes due to a shift in position such as seated-to-standing and supine-to-standing), were no different between patients treated with LX4211 and those on placebo.

"This new analysis of data from the trial shows that LX4211 lowers blood pressure to a greater extent in those patients who are in the greatest need of treatment, that is, those patients with hypertension," said Dr. Lapuerta. "Furthermore, patients with normal blood pressure showed little or no change on LX4211
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SOURCE Lexicon Pharmaceuticals, Inc.
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