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Lexicon Pharmaceuticals Reports on Clinical Program Status and 2012 Third Quarter Results
Date:11/6/2012

THE WOODLANDS, Texas, Nov. 6, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, today updated its drug development progress and reported financial results for the three and nine months ended September 30, 2012.

"Our positive results from a second Phase 2 study of telotristat etiprate provide further evidence of its potential to benefit patients with carcinoid syndrome," said Dr. Arthur T. Sands, president and chief executive officer of Lexicon.  "The initiation of a registrational Phase 3 study of telotristat etiprate in carcinoid syndrome patients represents another significant milestone in the advancement of Lexicon's clinical pipeline."

Key Progress

  • Lexicon is proceeding with preparations for the initiation of Phase 3 studies of LX4211, an oral, dual inhibitor of sodium glucose transporters 1 and 2, in type 2 diabetes and a Phase 2 clinical trial of LX4211 in type 1 diabetes. 
  • In October 2012, Lexicon announced positive top-line data from an open-label Phase 2 clinical trial of telotristat etiprate (LX1032) in carcinoid syndrome and the initiation of a Phase 3 registrational trial.  Lexicon also continues to enroll patients in a Phase 2 proof-of-concept trial evaluating the effect of telotristat etiprate on symptoms associated with ulcerative colitis.  Telotristat etiprate is an inhibitor of tryptophan hydroxylase that reduces peripheral serotonin production without affecting brain serotonin levels.
  • Lexicon continues to enroll patients with diarrhea-predominant irritable bowel syndrome (IBS-d) in a Phase 2 trial of LX1033, an inhibit
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  • SOURCE Lexicon Pharmaceuticals, Inc.
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