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Lexicon Pharmaceuticals Reports on Clinical Program Status and 2011 Third Quarter Results
Date:11/1/2011

AA levels, and adequate relief of gastrointestinal symptoms.  The drug has demonstrated a favorable safety profile in both studies to date.  In addition to the ongoing development of telotristat etiprate for carcinoid syndrome, Lexicon also plans to initiate a Phase 2 trial in patients with ulcerative colitis in the fourth quarter of this year.  
  • LX4211:  Lexicon reported data from a clinical study in which LX4211, a dual inhibitor of sodium-glucose cotransporters 1 and 2, demonstrated a favorable safety profile and beneficial effects on multiple parameters of glycemic control and cardiovascular health in healthy normal subjects, including decreased postprandial glucose levels without hypoglycemia and substantially reduced triglycerides.  Lexicon also presented data from a previous mechanistic study in patients with type 2 diabetes at the annual meeting of the European Association for the Study of Diabetes, which demonstrated that a single dose of LX4211 significantly increased circulating levels of GLP-1 (active and total) and PYY, important regulators of glycemic and appetite control.  Lexicon continues to enroll patients with type 2 diabetes in its 12-week Phase 2b clinical trial of LX4211, which remains on track to complete on schedule, with top-line results expected around mid-year 2012.  
  • LX1033:  Lexicon is preparing to initiate a Phase 2 study of LX1033, a serotonin synthesis inhibitor being developed as a potential treatment for irritable bowel syndrome (IBS).  In a Phase 1 study completed earlier this year in healthy volunteers, LX1033 produced reductions in 5-HIAA, a biomarker of serotonin production, comparable to those seen with an earlier clinical compound, LX1031, but with substantially lower and less frequent dosing.  Results from a Phase 2
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  • SOURCE Lexicon Pharmaceuticals, Inc.
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    6. Lexicon Announces Publication of Results From the Phase 2 Trial of LX1031 in Patients With Irritable Bowel Syndrome in Journal of Gastroenterology
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