Navigation Links
Lexicon Pharmaceuticals Reports Preliminary Results From Two Phase 1 Studies
Date:8/16/2012

THE WOODLANDS, Texas, Aug. 16, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, today reported preliminary results from Phase 1 studies of LX2931 and LX7101.

The Phase 1 study of LX2931, an inhibitor of sphingosine-1-phosphate lyase, was a dose-ranging study to explore higher doses of LX2931 in patients with rheumatoid arthritis. The study involved 10 patients with rheumatoid arthritis, eight of whom were randomized to LX2931 and two to placebo.  The primary endpoint in the study was an evaluation of the safety and tolerability of escalating doses of LX2931 compared with placebo over 12 weeks in subjects with active rheumatoid arthritis.  Secondary endpoints included pharmacokinetic and disease activity measures. 

Patients in the study received increasing doses over the course of the study, beginning at 50 mg QD and escalating to 500 mg QD.  LX2931 was well-tolerated at all doses evaluated, with no serious adverse events and no withdrawals due to adverse events. Seven of eight patients on LX2931 achieved drug trough levels greater than 60 ng/ml, a pharmacokinetic measure which a post-hoc analysis of data from a prior Phase 2 study of LX2931 had suggested was associated with better responses in American College of Rheumatology (ACR) measures in the study.  Six of the eight LX2931-treated patients experienced a drop from baseline in the DAS28 score of greater than or equal to 1.2, as did both placebo patients.  ACR20 and ACR50 responses were achieved at varying frequencies in both LX2931-treated and placebo patients, but two of eight patients dosed with LX2931 achieved an ACR70 response during the course of the study,
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon Pharmaceuticals To Present At The Wedbush PacGrow 2012 Management Access Conference
2. Lexicon Pharmaceuticals Reports On Clinical Program Status And 2012 Second Quarter Results
3. Lexicon to Provide Second Quarter 2012 Financial Results
4. Lexicon Announces Publication of Results of Two Studies of LX4211 in Patients with Type 2 Diabetes in the Journal Clinical Pharmacology & Therapeutics
5. Lexicon Announces Positive Results of LX4211 Phase 2b Trial For Type 2 Diabetes
6. Lexicon Presents Data Regarding the Mechanism of Action and Safety of LX4211 at American Diabetes Association Meeting
7. Lexicon Pharmaceuticals to present at the Jefferies 2012 Global Healthcare Conference
8. Lexicon Receives Funding for Phase 2 Clinical Trial of LX4211 in Type 1 Diabetes
9. Lexicon Pharmaceuticals Reports On Clinical Program Status And 2012 First Quarter Results
10. Lexicon to Provide First Quarter 2012 Financial Results
11. Nouveau Life Pharmaceuticals (NOUV) Releases Calcium & Vitamin D for Strong Bones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a leading ... of severely obese patients, today announced initial results ... selective inhibitor of methionine aminopeptidase 2 (MetAP2), in ... of genetic obesity.  These results showed improvements in ...
(Date:1/14/2014)... 14, 2014 The Brandeis Medical Center, led by Dr. ... premier and affordable laser tattoo removal experience with the advanced Astanza ... in providing high quality cosmetic services with cutting edge medical technology ... Southern California has seen a dramatic increase in ...
(Date:1/14/2014)... 14, 2014 NineSigma , Inc., the leading ... Innovation Leadership Summit , May 14-16, 2014 at the ... Ohio . This is the ... to breakthrough achievements through open innovation. Participants will learn ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... , FORT LAUDERDALE, Fla., Dec. 22 LifeSync ... purchased the Besson Patent Portfolio and other wireless vital ... the use of wireless, two-way, digital communication between patient-electrodes ... patient. The acquired patent portfolio includes additional wireless improvements ...
... , HULL, England and FT. SASKATCHEWAN, Canada, ... & Nephew plc (LSE: SN; NYSE: SNN ), ... substantially all of the assets of Nucryst Pharmaceuticals Corp. ("Nucryst") ... manufacturing assets from Nucryst,s Fort Saskatchewan, Canada operations and the ...
Cached Medicine Technology:Smith & Nephew Completes Acquisition of the Assets of Nucryst Pharmaceuticals Corp. 2Smith & Nephew Completes Acquisition of the Assets of Nucryst Pharmaceuticals Corp. 3
(Date:4/24/2014)... It is better to give than to receive at ... new study suggests. , The study found that 15- and ... their money to family members, are less likely to become ... risks or keeping the money for themselves. , The researchers ... Academy of Sciences . , The study focused on the ...
(Date:4/24/2014)... National Science Foundation has awarded LSU Health Sciences ... (REU) Site grant in the amount of $295,635. ... from diverse social and educational backgrounds, underrepresented in ... The project will provide students with training ... It will be led by Principal Investigator ...
(Date:4/23/2014)... frozen stool from healthy, unrelated donors was safe ... diarrhea caused by Clostridium difficile , according ... Clinical Infectious Diseases and available online. Known ... effective whether given via a colonoscope or a ... make this promising treatment more readily available to ...
(Date:4/23/2014)... director at the National Institute of Arthritis and Musculoskeletal ... recipient of the Ross Prize in Molecular Medicine, conferred ... Medicine . The award will be given on June ... Manhattan, followed by scientific presentations by Dr. O,Shea and ... Institutes of Health. , The award, which includes a ...
(Date:4/23/2014)... have developed a way to detect and measure cancer ... particles with tails of synthetic DNA., A team led ... used gold nanoparticles to target and bind to fragments ... variants, which can indicate the presence and stage of ... in a cell can be determined by examining the ...
Breaking Medicine News(10 mins):Health News:Study: Altruistic adolescents less likely to become depressed 2Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2
... in the journal Annals of Neurology, says that radiation emitted ... is the first study to show that mobile phone affect ... ,Italian researchers found in the current study that ... brain closest to the phone when used for 45 minutes ...
... set of dietary guidelines. Apart from the dietary guidelines ... Dietary Guidelines, the revised Food Guide Pyramid and food ... ,All the guidelines though are given by different organizations ... by all are increased intake of fruit and vegetables, ...
... mosquito-transmitted viral fever//, has claimed two lives in Madhya ... officials said. ,The disease, which has been reported ... the state through villages in Betul district bordering Maharashtra, ... stooped posture to the victim as a result of ...
... symptom of Sj?gren’s (SHOW-grins) syndrome was found to be the ... periods. ,Typical signs and symptoms include dry, gritty ... causes difficulty swallowing, dental cavities and enlarged parotid glands. The ... and in front of your ears. Other signs and symptoms ...
... treatments has been accused of placing money before patients//, ... drug. <BR.,Patients suffering from cancer linked to asbestos will ... is pemetrexed disodium, after a study conducted ... ,The group analyzed the cost effectiveness of the ...
... is made easy but the new fat-busting laser treatment called SmartLipo. ... to be a quicker and less invasive form of liposuction//. It ... the double chins areas. About six cosmetic surgery clinics in ... treatment. ,But he Food and Drug Administration (FDA) has ...
Cached Medicine News:
... offers an economical, ... alternative to existing ... guarantees accurate and ... the time-consuming recalibration ...
... 2000 is an ... for automated 96-/384-well ... With its ability ... any routine liquid ...
... Multidrop 384 offers lower consumption of ... screening applications. The Multidrop 384 is ... screening and microvolume dispensing into 384- ... outstanding flexibility. It can easily switch ...
RIA kit for the determination of blocking autoantibodies to the acetylcholine receptor (AChR) in serum...
Medicine Products: