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Lexicon Pharmaceuticals Reports On Clinical Program Status And 2012 Second Quarter Results
Date:7/31/2012

THE WOODLANDS, Texas, July 31, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, today updated its drug development progress and reported financial results for the three and six months ended June 30, 2012.

"Our positive top-line results from the Phase 2b study of LX4211 mark a very important milestone in the advancement of Lexicon's clinical pipeline towards late-stage development," said Dr. Arthur T. Sands, president and chief executive officer of Lexicon.  "We believe the robust reductions in hemoglobin A1c, body weight and blood pressure are driven by LX4211's unique, dual mechanism of action and that these findings, combined with the favorable safety profile observed, support progression of LX4211 into Phase 3 development."

Key Progress in Clinical Pipeline

  • Lexicon announced positive top-line data from a Phase 2b study of LX4211, an oral, dual inhibitor of sodium glucose transporters 1 and 2 (SGLT1 and SGLT2), in patients with poorly-controlled type 2 diabetes who were concurrently treated with metformin, an established diabetes therapy. LX4211 treatment produced substantial, dose-dependent and statistically-significant reductions in hemoglobin A1c (HbA1c), with patients in the LX4211 treatment arms (75 mg QD, 200 mg QD, 200 mg BID and 400 mg QD) having mean HbA1C reductions from baseline of 0.43, 0.52, 0.79 and 0.95 percent, respectively (p<0.001 for all treatment arms). In patients randomized to placebo, HbA1C decreased by 0.09 percent. LX4211 treatment also produced significant reductions in body weight and blood pressure.  Importantly, LX4211 was well tolerated and exhibited a favorable safety profile in the study. Lexicon also
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