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Lexicon Pharmaceuticals Reports On Clinical Program Status And 2012 First Quarter Results
Date:5/3/2012

THE WOODLANDS, Texas, May 3, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, today updated its drug development progress and reported financial results for the three months ended March 31, 2012.

"We continue to make excellent progress in our clinical-development stage programs and preclinical pipeline.  Our Phase 2b study of LX4211 in patients with type 2 diabetes has completed enrollment and is on track to obtain top-line data by mid-year," said Dr. Arthur T. Sands, president and chief executive officer of Lexicon.  "In addition, in the first quarter of 2012, we initiated Phase 2 studies of LX1033 in patients with diarrhea-predominant irritable bowel syndrome (IBS-d) and of LX1032 in patients with ulcerative colitis, and we launched a Phase 1-2 proof-of-concept study of LX7101 in glaucoma patients.  We look forward to obtaining data from these and our other ongoing studies and continuing the advancement of our clinical pipeline."

Key Progress in Clinical Pipeline

  • Lexicon completed enrollment in the ongoing 12-week Phase 2b study of LX4211, a dual inhibitor of sodium-glucose cotransporters 1 and 2, in patients with type 2 diabetes.  Top-line data from this study are anticipated by mid-year.
  • Lexicon is proceeding with preparations for Phase 3 registrational trials of telotristat etiprate (LX1032), an inhibitor of tryptophan hydroxylase that reduces peripheral serotonin production without affecting brain serotonin levels, in patients with carcinoid syndrome.  Lexicon als
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