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Lexicon Pharmaceuticals Provides Clinical Pipeline Update And Reports 2013 Second Quarter Financial Results
Date:7/30/2013

ed to placebo (p=0.002).  In contrast, patients with normal systolic blood pressure at baseline (<130 mmHg) experienced an average of only 1 mmHg reduction (p=0.6).  Lexicon also completed the pioneer portion of a Phase 2 clinical trial of LX4211 in type 1 diabetes, with LX4211 showing a favorable safety profile when given in combination with insulin.  Lexicon has initiated enrollment of patients in the placebo-controlled, expansion portion of the type 1 diabetes trial and is proceeding with preparations for the initiation of Phase 3 clinical trials of LX4211 in type 2 diabetes.
  • Telotristat etiprate (LX1032):  Telotristat etiprate is an inhibitor of tryptophan hydroxylase that reduces peripheral serotonin production without affecting brain serotonin levels. Lexicon has completed enrollment of patients in a Phase 2 clinical trial of telotristat etiprate in ulcerative colitis and continues to enroll patients in a pivotal Phase 3 clinical trial of telotristat etiprate in carcinoid syndrome.
  • LX1033: LX1033 is an inhibitor of tryptophan hydroxylase that acts locally in the gastrointestinal tract to reduce serotonin production without impacting brain serotonin levels. Lexicon is completing enrollment of patients in a Phase 2 clinical trial of LX1033 in diarrhea-predominant IBS (IBS-d).
  • LX2761: At the 73rd Scientific Sessions of the American Diabetes Association, Lexicon presented data on its newest clinical candidate for diabetes.  LX2761 acts locally in the gastrointestinal tract to reduce glucose absorption by inhibiting SGLT1 without any significant inhibition of SGLT2 in the kidney.  LX2761 was shown to improve glycemic control in two mouse models of diabetes, as measured by reductions in hemoglobin A1c and oral glucose tolerance
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    1. Lexicon to Report Second Quarter Financial Results on July 30, 2013
    2. Lexicon Presents Data at the American Diabetes Association Meeting On Blood Pressure Reduction and Weight Loss In Clinical Trial of LX4211
    3. Lexicon Presents Preclinical Data On LX2761, a New Clinical Candidate for Diabetes Designed to Reduce Glucose Absorption From Gastrointestinal Tract
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    11. Lexicon Pharmaceuticals Provides Clinical Pipeline Update And Reports 2012 Fourth Quarter And Full Year Financial Results
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