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Lexicon Pharmaceuticals Announces Reacquisition of All Rights to Symphony Icon Programs
Date:8/2/2010

% of any payment made on or prior to July 30, 2012 will be paid in common stock and no more than 50% of any payment made after such date will be paid in common stock.

LX1031 is an orally-delivered serotonin synthesis inhibitor that acts locally in the gastrointestinal tract targeting tryptophan hydroxylase (TPH), an enzyme necessary for the production of serotonin.  LX1031 recently demonstrated positive results in a Phase 2 clinical trial in patients with diarrhea-predominant and mixed forms of irritable bowel syndrome (IBS-D and IBS-M).  LX1032 is an orally-delivered serotonin synthesis inhibitor that acts peripherally to inhibit tryptophan hydroxylase without affecting brain serotonin levels.  LX1032 is currently in a Phase 2 clinical trial in patients with carcinoid syndrome.  LX1033 is a locally acting serotonin synthesis inhibitor with enhanced potency in IND-enabling studies.

Lexicon Conference Call:

Lexicon management will hold a conference call to discuss its reacquisition of the Symphony Icon programs at 3:00 p.m. Eastern Time on August 2, 2010.  The dial-in number for the conference call is 888-220-1244 (within the US/Canada) or 706-679-5615 (international).  The conference ID for all callers is 91995968.  An archived version of the conference call will be available on the Lexicon website through August 9, 2010.

About Lexicon

Lexicon is a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease.  Lexicon currently has four drug candidates in mid-stage development for diabetes, irritable bowel syndrome, carcinoid syndrome and rheumatoid ar
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SOURCE Lexicon Pharmaceuticals, Inc.
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2. Lexicon Presents Positive Outcome in IBS Patients Treated With LX1031 and Data Supporting Mechanism of Action
3. Lexicon to Provide Clinical Pipeline Update and Report First Quarter 2010 Financial Results
4. Lexicon to Present at BIO International Convention
5. Lexicon to Present Phase 2 Clinical Data for IBS Drug Candidate at Digestive Disease Week
6. Lexicon Announces Proposed $95 Million Common Stock Offering
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