Navigation Links
Lexicon Initiates Phase 2a Trial of LX6171 Drug Candidate for Cognitive Disorders
Date:12/5/2007

ll be set based on evaluation from the first stage pharmacokinetic study using the new formulation. The second stage will evaluate the safety and tolerability of LX6171 oral suspension in subjects exhibiting AAMI and will measure the cognitive effects of LX6171 in these subjects using the Cognitive Drug Research battery, along with other psychometric instruments. The study is being conducted in Europe, with initial results expected by the end of 2008.

About LX6171

LX6171 is an orally-bioavailable small molecule developed by Lexicon scientists to inhibit a membrane protein expressed exclusively in the central nervous system and found at synaptic vesicles and presynaptic membranes of glutamatergic neurons. The protein targeted by LX6171 was identified through Lexicon's large-scale gene knockout program, the Genome5000(TM). Knockout mice lacking this protein showed improved learning and memory compared with controls. In preclinical studies, administration of LX6171 resulted in improved performance in tests of learning and memory in mice. In Phase 1 clinical trials, LX6171 was generally well tolerated at all dose levels and showed good systemic exposure.

About Lexicon

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has clinical programs underway for such areas of major unmet medical need as irritable bowel syndrome, cognitive disorders, and rheumatoid arthritis. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bris
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
2. Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome
3. Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis
4. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
7. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
8. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
9. Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma
10. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
11. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... DALLAS and NEW YORK ... PHARMACEUTICALS, INC. (OTCBB: ACCP), has signed an exclusive, ... for the development and commercialization of its proprietary ... new corporate management team and its intention to ... Biopharmaceuticals, Inc.™, and its plans to pursue a ...
(Date:9/22/2014)... Sept. 22, 2014 Research and Markets ... Chinese Diclofenac Industry Report 2014" report to their ... Industry Report 2014 is a professional and in-depth study ... with a focus on the Chinese situation. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:9/20/2014)... 20, 2014 /CNW/ - The issue: Mylan Pharmaceuticals ULC Canada, ... of its Mylan-Nitro Spray 0.4 mg/metered dose due to the ... pump component. A missing "dip tube" could ... the patient. This defect may lead patients to believe they ... to access it. Not receiving nitroglycerin could place them at ...
Breaking Medicine Technology:Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 2Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 3Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 4Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 5Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 6Global and Chinese Diclofenac Industry Report 2014 2Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2
(Date:9/22/2014)... September 22, 2014 The Spa Standard, ... to lead the start-up in developing content and courses ... to the company over 15 years of experience in ... resort spa management with companies including Orient Express Hotels ... the role of educator, Jenny gained extensive industry insight ...
(Date:9/22/2014)... the proverbial needle in the cancer antigen haystack, according ... of Experimental Medicine . , As cancer ... creates new versions of proteins, some of which are ... cells, prompting the cells to attack and eliminate the ... of the mutations in a patient,s cancer and to ...
(Date:9/22/2014)... 2014--Women who are about to be released from prison ... if they are to successfully reintegrate into their communities ... study. , Almost half of all female prisoners are ... and most have multiple prison terms, mainly for drug-related ... Michael,s Hospital, conducted one-on-one interviews with women who were ...
(Date:9/22/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... GLOBAL MARKETS, the global market for autoimmune disease ... billion by 2019, with a five-year compound annual ... holds the highest market potential due to an ... western lifestyles. , In recent decades, autoimmune ...
(Date:9/22/2014)... on Trauma, patients with severe injuries should be treated ... centers have the resources to provide the best care ... major trauma patients in 2010 actually received their treatment ... a new study from the Center for Pediatric Trauma ... at Nationwide Children,s Hospital. Those patients are "undertriaged." The ...
Breaking Medicine News(10 mins):Health News:The Spa Standard Appoints Vice-President of Content and Course Development 2Health News:Involving female offenders in release planning can increase reintegration success 2Health News:Global Market for Autoimmune Disease Diagnostics to Reach Nearly $13.1 Billion in 2019; Southern Asia Holds the Highest Potential 2Health News:Global Market for Autoimmune Disease Diagnostics to Reach Nearly $13.1 Billion in 2019; Southern Asia Holds the Highest Potential 3Health News:New study finds 34 percent of severely injured patients undertriaged in the United States 2Health News:New study finds 34 percent of severely injured patients undertriaged in the United States 3
... Health plans today proposed guaranteed coverage for people with pre-existing ... , , Under the ... market would be required to offer coverage to all applicants ... individuals were required to maintain health insurance. , ...
... Inc. (NYSE: PRX ) today announced that it ... the U.S. to market budesonide,inhalation suspension, which is a generic ... asthma. Par began,shipping 0.25 mg/2 ml and 0.5 mg/2 ... Full-year US sales for PULMICORT(R) in 2007 totalled ...
... human trial , , WEDNESDAY, Nov. 19 (HealthDay News) -- ... patients may not slow the disease, new research suggests. ... spurred by promising animal research that had suggested that ... on the brain. , However, "the study suggests that ...
... , TORONTO, Nov. 19 /PRNewswire-FirstCall/ - Bradmer ... and commercialization of cancer therapies, announced today that it ... data from Neuradiab(TM) at the Society for Neuro-Oncology,s (SNO) ... from two previously conducted Phase II trials, is titled ...
... medicine community: "Are Your Cells Free?" Learn more about InVitria at TERMIS ... ... Collins, CO (PRWEB) November 19, 2008 -- Stem cell culture researchers ... Tissue Engineering Meeting TERMIS in San Diego on Dec. 7-10. ...
... anniversary of the adoption of the United Nations Convention on the ... ARLINGTON, Va., Nov. 19 The Child Welfare League of America ... Rights of the Child (CRC), the American Psychological Association, and the ... Children,s Health Issues and The Convention on the Rights of the ...
Cached Medicine News:Health News:Health Plans Propose Guaranteed Coverage for Pre-Existing Conditions and Individual Coverage Mandate 2Health News:Health Plans Propose Guaranteed Coverage for Pre-Existing Conditions and Individual Coverage Mandate 3Health News:Par Pharmaceutical Begins Shipment of Budesonide Inhalation Suspension Immediately 2Health News:Growth Hormone Boost May Not Slow Alzheimer's 2Health News:Growth Hormone Boost May Not Slow Alzheimer's 3Health News:Bradmer to present poster on progression free survival and overall survival data from Neuradiab(TM) Phase II trials at Society for Neuro-Oncology Meeting 2Health News:Bradmer to present poster on progression free survival and overall survival data from Neuradiab(TM) Phase II trials at Society for Neuro-Oncology Meeting 3Health News:Bradmer to present poster on progression free survival and overall survival data from Neuradiab(TM) Phase II trials at Society for Neuro-Oncology Meeting 4Health News:InVitria to Launch "BE FREE" Promotion at TERMIS '08 in San Diego 2Health News:Linda Spears, CWLA Vice President of Policy Will Speak at Senate Briefing 2
... November 2005. Specifications, including colors, subject to ... lb (2.3 kg), FreeStyle by AirSep is ... for those patients who know no boundaries. ... FreeStyle captures the heart of what it ...
... is AirSep Corporations most economical line of ... lpm of therapeutic oxygen in home, hospital, ... of units in daily use throughout the ... known for high performance, easy maintenance, and ...
... to 10 LPM of oxygen reducing the delivery ... M10 is engineered to reduce the cost of ... fewer parts than any other concentrator on the ... you to reduce expenditure on accessories and unnecessary ...
... conserver, it's important to have a choice that ... name synonymous with innovative excellence, offers two great ... automatic and value packed conservers., ,With its ... used 8 hours a day for 3 to ...
Medicine Products: