Navigation Links
Lexicon Initiates Phase 2a Trial of LX6171 Drug Candidate for Cognitive Disorders
Date:12/5/2007

THE WOODLANDS, Texas, Dec. 5 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced today that dosing has commenced in a Phase 2a clinical trial with LX6171, an oral drug candidate for the treatment of cognitive impairment associated with disorders such as Alzheimer's disease, schizophrenia, and vascular dementia. The initial stage of the trial will assess the bioavailability of a new oral-suspension formulation in healthy elderly subjects with a second stage evaluating safety, tolerability and cognitive effects in elderly subjects with age-associated memory impairment (AAMI).

"AAMI is an emerging area of clinical research and offers an expedient population for obtaining proof-of-concept with a drug candidate, like LX6171, that has a broad range of potential applications in the area of cognitive disorders," said Philip M. Brown, M.D., J.D., vice president of clinical development at Lexicon. "Following the strength of the Phase 1 data indicating LX6171 is generally well tolerated, we have adopted a two-stage strategy for Phase 2a in order to transition to our new oral suspension formulation and to assess for improvements in a variety of cognitive dimensions as we enter the elderly population."

Phase 2 Study Design

The initial stage of the trial will assess the bioavailability of a single-dose oral suspension in 16 healthy elderly subjects. The second stage will be a randomized, double-blind, placebo-controlled evaluation of safety, tolerability, and cognitive effects in approximately 120 subjects over four weeks. This stage is anticipated to include three groups of 40 subjects each, exploring two dose levels with a placebo control. Exact dose levels for the second stage wi
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
2. Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome
3. Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis
4. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
7. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
8. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
9. Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma
10. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
11. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... the "Global and Chinese Medical X-ray Film Industry ... http://photos.prnewswire.com/prnh/20130307/600769 Global And ... professional and in-depth study on the current state of ... on the Chinese situation. The report provides a ...
(Date:7/11/2014)... On Thursday, July 10, ... Dow Jones Industrial Average finished the day 0.42% lower at ... The losses were broad based as eight out of ten ... Care Sector Index ended the day at 711.88, down 0.02%, ... month. Investor-Edge has initiated coverage on the following equities: Covidien ...
(Date:7/11/2014)... Neurelis, Inc. ("Neurelis") today announced an agreement ... held by Biotie to purchase Neurelis, clearing the way ... diazepam) for pediatric and adult epilepsy patients who experience ... Biotie has advanced the development program for NRL-1 and ... work required for NDA submission to the FDA.  Given ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... /PRNewswire/ -- A new study suggests,strong variation in ... U.S. Anaphylaxis is a severe allergic,reaction that can ... differences in EpiPen prescribing, a marker of,anaphylaxis risk, ... low levels of vitamin D,from lack of sunshine, ...
... ,Celiac disease (CD) is an autoimmune inflammatory disease ... genetically susceptible persons by the ingestion of the ... The condition is thought to result from the ... response, leading to mucosal inflammation, villous atrophy, and ...
Cached Medicine Technology:Large Geographic Differences in EpiPen Prescriptions in the U.S.,From the Journal of Allergy and Clinical Immunology 2Non-Invasive Diagnostic Tests for Celiac Disease 2Non-Invasive Diagnostic Tests for Celiac Disease 3
(Date:7/14/2014)... New York, NY (PRWEB) July 14, 2014 ... authority Danny Seo and Harris Publications, debuts with a ... The lifestyle magazine looks at living the healthy, ... authoritative voice that covers everything from food, beauty, travel, ... America’s leading guru of green living. , “Instead of ...
(Date:7/14/2014)... According to the Blood Pressure Solution book ... that features a series of new information on high ... this book can help readers understand more about blood pressure. ... and effective methods to control hypertension naturally. ... Vkool, was penned by Ken Burge, a medical researcher and ...
(Date:7/14/2014)... July 14, 2014 Vaginal Mesh ... against seven different pelvic mesh manufacturers in the U.S. ... & Schulte LLC. The federal complaints are pending against ... 2327), American Medical Systems (MDL No. 2325), and C.R. ... there are 58,262 Vaginal Mesh lawsuit claims pending, according ...
(Date:7/14/2014)... TherapySites, the leading ... professionals, announced today its affiliation with the ... This new relationship allows TherapySites to continue ... members, adding exclusive benefits and promotional offers. , ... dedicated to providing online marketing solutions specifically for ...
(Date:7/14/2014)... July 14, 2014 Townsend Security, ... announced its new IBM i (AS/400, iSeries) Two ... (ISVs). As security threats evolve and make passwords ... struggle to modernize their applications and implement two ... makes it easy for ISVs on the IBM ...
Breaking Medicine News(10 mins):Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 2Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 3Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 4Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 5Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 6Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 2Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5Health News:TherapySites Partners With the Licensed Professional Counselors Association of North Carolina to Make Online Marketing Available to All Therapists 2Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 2Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 3
... another bout of West Nile, a potentially fatal, mosquito-spread infection. ... Control of the Harris county has said that the situation ... is still a large percentage of people in Houston who ... repellants or going out at night in short-sleeve shirts can ...
... out with the report that with UK leading the group, cancer ... use of new drugs. ,The study termed uptake of ... as well as in New Zealand, Poland, Czech Republic and South ... US were leaders in using new cancer drugs. ,The ...
... forty per cent (37 per cent) of British women and a ... unattractive on holiday as a result of excessive exposure to the ... has been conducted to highlight Sun Awareness Week, which kicks off ... over unsightly sunburn has meant that one in three Brits could ...
... eyes, say experts, who advise frequent short breaks every half ... ,Studies have shown that eyestrain and other vision problems ... people using video display terminals at work, said Kerry Beebe, ... ,The most common symptoms are eyestrain, blurred vision, ...
... the brakes on a racing heartbeat. ... the May 11 issue of Circulation Research how an enzyme ... of the heart's "fight-or-flight" reaction to adrenaline. ,A ... setting the pace of the beating heart, triggering its neighbor ...
... who is on a visit to the US, has ... in Hyderabad, promising to provide all necessary infrastructure. ... the signing of an MoU between Stanford University, the ... Research Institute) in California Thursday. ,Under the ...
Cached Medicine News:Health News:Health Authorities Fear West Nile Season Again in US 2Health News:Britains Complacent Attitude To Uptake Of New Cancer Drugs Revealed 2Health News:Burnt Brits Don't Feel Hot 2Health News:Many Hours on Computer may Harm Eyes 2Health News:Slowing the Racing Heart 2Health News:Reddy Asks Stanford University to Open Hyderabad Campus 2
... TFC Unite Device is the anterior alternative to ... Unite device features the same 70% fenestrations as ... fenestrations is paramount in the formation of new ... Unite system promotes load sharing between the device ...
Steinmann Pins are available in six point styles ranging from 5/64 to 3/16 in. diameters, in standard 9 in. (230 mm) lengths with threaded and smooth tips. Material: DePuy certified stainless steel. ...
... implant is the only approved radiolucent stand-alone ... assessment with the proven reliability of the ... Vista System is constructed of radiolucent, carbon-fiber ... unobstructed radiologic visualization, providing a new level ...
... Confirmatory (Western Blot): The Genetic Systems HIV-1 ... for the detection of antibodies to HIV-1. The ... of HIV-1 grown in the CEM cell line. ... devoid of HLA Class ll antigens, helps reduce ...
Medicine Products: