Navigation Links
Lexicon Completes Phase 1 Clinical Trial and Initiates Phase 2 Clinical Trial of LX4211 in Patients With Type 2 Diabetes
Date:9/15/2009

THE WOODLANDS, Texas, Sept. 15 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, obtained favorable results from recently completed Phase 1 studies of LX4211 and announced today that it has initiated a Phase 2 clinical trial of the drug candidate in patients with type 2 diabetes mellitus. LX4211 is an orally-delivered, small molecule drug candidate that inhibits the sodium glucose transporter 2 (SGLT2). LX4211 is Lexicon's fourth drug candidate currently being tested in Phase 2 clinical trials.

"LX4211 offers an opportunity to treat diabetes by increasing urinary glucose excretion through a mechanism of action that is expected to avoid some of the disadvantages of existing diabetes drugs that result in storage of excess glucose," said Brian P. Zambrowicz, Ph.D., executive vice president and chief scientific officer at Lexicon. "By contrast, LX4211 through inhibition of SGLT2 has the potential to reduce caloric load and thereby enhance overall glucose homeostasis in patients with type 2 diabetes."

In the recently completed Phase 1 clinical trial in normal healthy volunteers, LX4211 was well tolerated at all dose levels and produced a dose-dependent increase in urinary glu
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicons Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA
2. Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results
3. Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting
4. Lexicon Initiates Phase 2a Trial of LX6171 Drug Candidate for Cognitive Disorders
5. Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis
6. Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome
7. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
8. Shire Completes Submission of NDA for Velaglucerase Alfa for Type 1 Gaucher Disease and Reports Positive Results for Remaining Two Phase III Trials
9. Cardium Completes Initial Patient Evaluation Period for MATRIX Phase 2b Excellarate Clinical Study
10. CardioDx Completes Validation Study of First-Of-Its-Kind Genomic Test for Coronary Artery Disease
11. R-Tech Ueno Completes Subject Enrollment in Phase 2 Clinical Study of 0.15% UF-021
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... Texas , March 3, 2015  UnaliWear announces ... provides advanced support for seniors that guards against wandering ... The new wearable – the Kanega watch ... its kind to use an easy speech interface rather ... medical information without human input. The ...
(Date:3/3/2015)... -- American Biosurgical, LLC ("ABI") ( www.americanbiosurgical.com ) a ... in the design, development and production of innovative ... device companies has announced the acquisition of MTI ... cable manufacturer based in North Carolina.  The new ... name MTI Medical Cables.  The ...
(Date:3/3/2015)... Ariz. , March 3, 2015  Michigan brothers ... heart condition called arrhythmogenic right ventricular dysplasia, or ARVD, a ... cause of sudden death among young athletes. In ... at a basketball game. They later tested Dominique and found ... to a February 19, 2015 story in The Ann ...
Breaking Medicine Technology:UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2American Biosurgical Acquires MTI Corporation 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 3
(Date:3/4/2015)... 04, 2015 Theme and plugin developers from ... pack for Final Cut Pro X entitled ProFont NoteBook , ... to any FCPX editors project.” Said Christiana Austin, CEO of ... to add animated font to their FCPX media.” , With ... all within Final Cut Pro X. ProFont Notebook offers users ...
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 Bird ... commercial, industrial and residential applications now offers its popular ... , The humane, highly efficient bird deterrent ... to match the color and décor of the building ... standard colors—brick red, white, crystal clear, light grey, brown, ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Professionals with ... more targeted outreach from companies, according to a new ... 2014 survey of 235 professionals with disabilities , ... online job search tools, including ones that are geared ... work. Some highlights:, ,     Online job search ...
(Date:3/4/2015)... March 04, 2015 Rocket Builders’ “Ready ... Columbian companies that have the best prospect for growth ... when we choose the Ready to Rocket companies, we ... technical innovation with market opportunity. Prizm Media Inc. is ... right customers at the right time,” said Reg Nordman, ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 The medical ... companies whose management forgot – or ignored or didn't ... Validate the market based on physician input before proceeding ... – more specifically, founders – become so enamored of ... key question: Will physicians use the device?” says ...
Breaking Medicine News(10 mins):Health News:Announcing a New Title Pack from Pixel Film Studios, ProFont NoteBook for Final Cut Pro X 2Health News:Plastic Bird Spikes Now Come in 7 Colors to Blend in With Their Surroundings 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 3Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 2Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 3Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 2Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 3
... NEW BRUNSWICK, N.J., May 13 Johnson & Johnson ... Deutsche Bank 34th Annual Health Care Conference on Tuesday, ... Sheri McCoy, Worldwide Chairman, Pharmaceuticals Group for Johnson ... scheduled at 10:50 a.m. (Eastern Time).This broadcast will be ...
... 13 Accumetrics, Inc. announces that it has enrolled ... ( G auging R esponsiveness with A ... hrombosis A nd S afety). The trial ... clinicians with actionable information for patients who are poor ...
... Shengtai,Pharmaceutical, Inc. (OTC Bulletin Board: SGTI) ("Shengtai" or ... pharmaceutical grade,glucose products in China, today announced that ... ended March 31, 2009 after the close of ... Management will conduct a conference call,on Friday, May ...
... (Nasdaq: ESRX ) announced that it will present ... May 19, 2009 at 10:10 a.m. EDT at the InterContinental ... the Internet and can be accessed on the investor relations ... RealPlayer or Windows Media Player is needed to listen ...
... Winner Medical Group Inc.,(OTC Bulletin Board: WMDG) ("Winner Medical", or ... ended March 31,2009. The Company,s results are detailed in its ... Commission. , , Second Quarter 2009 Highlights, ... 15.31% over the second quarter of, ...
... expression and activity of Cystathionase is reduced in ... and impaired generation of hydrogen sulphide, two factors ... resistance. , In the present study the analysis ... presence of an inverted repeat sequence. Administration of ...
Cached Medicine News:Health News:Accumetrics, Inc. Announces 1000th Patient Enrolled in GRAVITAS Trial 2Health News:Shengtai Pharmaceutical Schedules 2009 Third Quarter Financial Results and Conference Call 2Health News:Shengtai Pharmaceutical Schedules 2009 Third Quarter Financial Results and Conference Call 3Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 2Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 3Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 4Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 5Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 6Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 7Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 8Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 9Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 10Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 11Health News:Farnesoid X receptor regulates cystathionase 2
One inch disposable patch electrode uses a specially formulated adhesive solid gel. Reusable lead wire with snap connector provides economic benefits. Ideal for sleep studies where leg movement or EK...
10-mm (0.4-in) diameter cups have multi-color lead wires and 2-mm (0.08-in) holes for easy paste/collodion application. Available in a variety of lengths to suit many different needs....
... head cap systems are packaged to provide ... Electro-Cap System features pure tin electrodes positioned ... you place your order, please specify which ... cap system and whether you want regular ...
... Made with elastic fabric, these head ... you need to begin testing. Each Electro-Cap ... to the International 10-20 System. When you ... you are using with your head cap ...
Medicine Products: