Navigation Links
Lexicon Announces Publication of Results From the Phase 2 Trial of LX1031 in Patients With Irritable Bowel Syndrome in Journal of Gastroenterology
Date:8/10/2011

THE WOODLANDS, Texas, Aug. 10, 2011 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, announced today that results from the Phase 2 clinical trial of LX1031 in patients with non-constipating irritable bowel syndrome (IBS) were published earlier this week in the August 2011 edition of the journal Gastroenterology.  The issue also included an expert editorial discussing the study, its implications and the potential utility of this mechanism of action in gastrointestinal disease.

Results of the Phase 2 study showed that the tryptophan hydroxylase inhibitor, LX1031, was well tolerated and provided clinical benefit to patients with non-constipating IBS, showing improvements in a global assessment of adequate relief from IBS pain and discomfort and in stool consistency.  Notably, symptom relief correlated with reduced levels of 5-HIAA, a biomarker of serotonin production.

Lexicon recently completed a Phase 1 study of LX1033, a follow-on compound that is significantly more potent than LX1031.  In the study, LX1033 produced reductions in the 5-HIAA biomarker in healthy volunteers comparable to those seen with LX1031, but with lower and less frequent dosing.  Lexicon intends to advance LX1033 into a Phase 2 clinical trial as its lead drug candidate in IBS.

About Lexicon

Lexicon is a biopharmaceutical company focused on discovering breakthrough treatments for human disease.  Lexicon currently has four drug programs in mid-stage development for diabetes, irritable bowel syndrome, carcinoid syndrome and rheumatoid arthritis, all of which were d
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Phase 2 Trial of Lexicons LX1032, Telotristat Etiprate, Shows Positive Results in Carcinoid Syndrome
2. Lexicon Pharmaceuticals Reports on Clinical Program Status and 2011 Second Quarter Results
3. Lexicons IBS Drug Candidate, LX1033, Successfully Completes Phase 1 Clinical Trial
4. Lexicon Presents LX4211 Mechanism of Action Data at American Diabetes Association Meeting and Announces Commencement of Phase 2b Clinical Trial in Type 2 Diabetes
5. Lexicon Pharmaceuticals Announces Webcast of 2011 Annual R&D Day
6. Lexicon Pharmaceuticals Reports on Clinical Program Status and 2011 First Quarter Results
7. Lexicon to Provide First Quarter 2011 Financial Results
8. Lexicon Pharmaceuticals Appoints Dr. Pablo Lapuerta Chief Medical Officer
9. Lexicon Pharmaceuticals to Present at the Cowen and Company 31st Annual Health Care Conference
10. Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Fourth Quarter and Full Year Financial Results
11. Lexicon to Report Fourth Quarter and Year End 2010 Financial Results on February 24, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Dec. 23, 2014 Echo Therapeutics, Inc. ... company focused on skin permeation, continuous glucose monitoring ... W. Hollander has been appointed Chief Executive ... more than 20 years of experience in the ... most recently served as Vice President, Business Development, ...
(Date:12/24/2014)... Dec. 23, 2014   Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders, today ... of the Marketing Authorization Application (MAA) for sebelipase ... the company,s request for accelerated assessment, which has ... time.   The MAA, and the ...
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... CeNeS Pharmaceuticals plc,(LSE: CEN), the Cambridge based biopharmaceutical ... the respected scientific,journal 'Synapse'* on its Phase II ... as a potential treatment for neuropathic,pain. The independent ... undertaken with CNS 5161. , In the study ...
... in Humans of CTI's,Programmable, Pulsatile, Passive Transdermal ... TRENTON, N.J., May 03, 2007 /PRNewswire/,-- Chrono ... of its first phase human clinical trial ... ChronoDose(TM). CTI intends to publish this,clinical data ...
Cached Medicine Technology:Independent publication supports the profile of CeNeS phase II,compound, CNS 5161 2Independent publication supports the profile of CeNeS phase II,compound, CNS 5161 3Successful Human Clinical Trial of Chrono Therapeutic's Drug/Device,Combination Product - ChronoDose 2Successful Human Clinical Trial of Chrono Therapeutic's Drug/Device,Combination Product - ChronoDose 3
(Date:12/25/2014)... December 26, 2014 The ... combines beauty, strength and durability. Today, the business ... which is valid until Jan. 30, 2015. , ... of traditional hardwood. BambooFlooringChina.com is a well-known brand ... consumers worldwide to find a reliable bamboo flooring ...
(Date:12/25/2014)... 26, 2014 “Every three months the trends ... A-line sweetheart evening dress will be one of the hottest ... of Yunx.co.uk says. Today, the company releases 26 A-line sweetheart ... to 80% off. , “We are trying our best ... with our latest designs. Along with affordable prices, we provide ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas Sale, ... has chosen their best-selling lace wedding dresses, vintage bridesmaid ... season. , Now, BellasDress.com features popular women’s dresses, ... discount prices. The business hopes everyone can have a ... , “All our elegant products are made with exquisite ...
(Date:12/25/2014)... updated its blog to provide professional shopping tips on wedding and ... LunaDress.co.uk come with big discounts, up to 80 percent off. , ... to be a most exciting memory and can show off a ... a wedding. On the updated fashion blog, ladies can now find ... day . , Going out with friends to a party is ...
(Date:12/25/2014)... Dec. 24, 2014 (HealthDay News) -- Among early stage ... less than half of one percent will eventually develop ... analysis reveals. The finding comes from a review ... 1998 and 2007, and it suggests that the risk ... what experts had previously thought. "The frequency of ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... 2007) Lower muscle mass and an increase in body ... exercise is a proven way to prevent the loss of ... Mark Tarnopolsky shows that taking a combination of creatine monohydrate ... exercise training provides even greater benefits. , The ...
... 2 Speaker Nancy Pelosi,released the following statement ... The Speaker was presented the National Breast,Cancer Coalition,s ... York City last,night: "National Breast Cancer Awareness ... and to recommit ourselves to advancing prevention, improving,treatments, ...
... imagine iPhones, laptops and flash drives. But more ... a newly updated inventory of nanotechnology consumer products ... and health products. , Maintained by the ... inventory includes Head NanoTitanium Tennis Racquets, Eddie Bauer ...
... is a statement,by Linda A. Suydam, D.P.A., president ... to inaccurate and misleading media reports,surrounding the U.S. ... Nonprescription Drugs Advisory Committee and Pediatric Advisory,Committee scheduled ... the makers of pediatric, over-the-counter cough and cold,medicines ...
... WASHINGTON, Oct. 2 Speaker Nancy Pelosi and,Senate Majority ... sending President Bush the Children,s Health Insurance,Program (CHIP) legislation:, ... a bipartisan bill,to insure 10 million of our nation,s ... American people that the President will sign the bill ...
... Offer Both Suspension and Tablet Forms, PRINCETON, N.J., ... subsidiary of Ranbaxy Laboratories Limited (RLL),announced today that RLL ... Administration (U.S. FDA) to manufacture and market Clarithromycin for,Oral ... Ranbaxy is the first,company to have been granted a ...
Cached Medicine News:Health News:Nanotechnology: not just for geeks 2Health News:Statement from the Consumer Healthcare Products Association on the Safety of Pediatric Over-the-Counter Medicines 2Health News:Ranbaxy First to Gain Approval to Manufacture and Market Clarithromycin for Oral Suspension, USP 2
Suitable for mild to moderate ACL and/or PCL, MCL and LCL instabilities, this neoprene brace with extended hinge bars is an ideal intermediate-level product that can be used in sporting activities. C...
Provides range-of-motion control for both flexion and extension along with a drop lock feature...
Provides comfortable compression, support and immobilization for the knee...
Dynamic brace that provides a low load, prolonged stretch to the connective tissue around the joint using an adjustment hinge with a built-in tension spring...
Medicine Products: