Navigation Links
Lexicon Announces Positive Results of LX4211 Phase 2b Trial For Type 2 Diabetes
Date:6/25/2012

THE WOODLANDS, Texas, June 25, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), announced today that LX4211, an investigational, oral, dual inhibitor of sodium glucose transporters 1 and 2 (SGLT1 and SGLT2), showed substantial, dose-dependent, statistically-significant reductions in hemoglobin A1c (HbA1c) in a Phase 2b trial in patients diagnosed with poorly-controlled type 2 diabetes who were concurrently treated with metformin, an established diabetes therapy. LX4211 treatment also produced significant reductions in body weight and blood pressure. Importantly, LX4211 treatment had a favorable safety profile and was well tolerated in the study.

LX4211, a unique dual inhibitor, reduces the amount of glucose that enters the bloodstream from the gastrointestinal (GI) tract by inhibiting SGLT1, the major transporter responsible for glucose absorption, and enhances glucose excretion in the urine by inhibiting SGLT2, the major transporter responsible for glucose reabsorption by the kidney. Lexicon has previously demonstrated that SGLT1 inhibition by LX4211 increases GLP-1 and PYY, GI hormones associated with glycemic control and appetite.

"New diabetes therapies will need to help patients safely control blood sugar and address other metabolic parameters that play a role in this pervasive disease," said Dr. Arthur Sands, president and chief executive officer of Lexicon. "The positive results obtained when LX4211 is combined with metformin suggest it has the potential to make a meaningful contribution to diabetes care."

In this 12-week dose-ranging study conducted in over 50 centers in the United States, 299 patients with poorly controlled type 2 diabetes on metformin therapy were randomized to receive either LX4211 or placebo. The primary endpoint of the study was the change in HbA1C, a measure of glycemic cont
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon Presents Data Regarding the Mechanism of Action and Safety of LX4211 at American Diabetes Association Meeting
2. Lexicon Pharmaceuticals to present at the Jefferies 2012 Global Healthcare Conference
3. Lexicon Receives Funding for Phase 2 Clinical Trial of LX4211 in Type 1 Diabetes
4. Lexicon Pharmaceuticals Reports On Clinical Program Status And 2012 First Quarter Results
5. Lexicon to Provide First Quarter 2012 Financial Results
6. Shire Announces that the US Food and Drug Administration has Responded to its Citizen Petition for Adderall XR and has Approved One Abbreviated New Drug Application for Generic Adderall XR
7. ERT Announces Stockholder Approval of Merger
8. Biodel Announces $18.5 Million Private Placement
9. BioElectronics Corporation Announces Indian Distributors Ecommerce Website
10. Marken Announces Global Advisory Board
11. Community Foundation Announces $2.6 Million In Grants From Centinela Medical Funds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... August 27, 2015 According to a new ... Toilet, Seating, Universal, Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage ... 2020", published by MarketsandMarkets, the Medical Lifting Sling Market is poised ... in 2015, at a CAGR of 11.4 % from 2015 to ... ma rket data T ables and 65 ...
(Date:8/27/2015)... --  Women Grow , the fastest-growing professional networking organization for ... Cannabis World Congress & Business Exposition (CWCBExpo) in ... educational sessions. CWCBExpo in LA will take place September 16-18, ... Center in Los Angeles, CA , and ... the marijuana industry. The Women Grow tracks at ...
(Date:8/27/2015)... Aug. 27, 2015  A mere one in seven ... Allen Hamilton . A new white paper ... are impeding and disrupting manufacturers, success. The ... Improve Value In Product Development Processes provides insight ... and how it affects the product development process resulting ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4New White Paper Reveals How Manufacturers Can Improve Product Development Processes 2
... no stent thrombosis or MACE,after one year, ... 2007,/PRNewswire-FirstCall/ -- Boston Scientific Corporation today,welcomed the ... FIRST, II,and III Clinical Trials, reaffirming prior ... Express2(TM) Paclitaxel-Eluting,Coronary Stent System and XIENCE(TM) V ...
... of Choroidal,Neovascularization (CNV) in an AMD Model, SAN ... ,the category leader in therapeutic agents against bioactive ... of human age-related macular degeneration (AMD). , The ... the,Association of Research in Vision and Ophthalmology (ARVO) ...
Cached Medicine Technology:SPIRIT Clinical Data Reaffirm Strength of Taxus and Promus,Drug-Eluting Coronary Stent Systems 2SPIRIT Clinical Data Reaffirm Strength of Taxus and Promus,Drug-Eluting Coronary Stent Systems 3Lpath Demonstrates 'First-in-Class' AMD Results With Its Lead Drug,Candidate, Sphingomab 2Lpath Demonstrates 'First-in-Class' AMD Results With Its Lead Drug,Candidate, Sphingomab 3Lpath Demonstrates 'First-in-Class' AMD Results With Its Lead Drug,Candidate, Sphingomab 4
(Date:8/28/2015)... Boynton Beach, FL. (PRWEB) , ... August 28, ... ... creating problems for businesses nationwide. Addictions specialist, Dr. James Strawbridge, gives a new ... Strawbridge believes that it should begin with the employer and employees getting together ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... a low cost. Personalized with practice contact information and logos, Calendars stand alone ... can also incorporate Calendars into seasonal mailings, thank you and welcome communications, and ...
(Date:8/28/2015)... ... August 28, 2015 , ... Healthpointe clinics throughout ... go deep sea diving. The act of recreational diving exposes the body ... reasons, it is vital that all recreational and professional divers undergo regular comprehensive ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... of the top 5 millionaire dating sites . According to the listings, ... the second best in this category. , A spokesperson of Top5MillionaireDatingSites.com ...
(Date:8/28/2015)... ... , ... Inc. magazine today ranked PREVENT Life Safety No. 3660 ... private companies. The list was unveiled online at Inc.com and is the most competitive ... years, PREVENT ranks higher on the list than any other company in their industry. ...
Breaking Medicine News(10 mins):Health News:SmartPractice® Introduces 2016 Calendars for Dental Practice Giveaways 2Health News:Healthpointe Now Offering Scuba Physicals 2Health News:Top5MillionaireDatingSites.com Publishes Its First List of Reviews of the Best Millionaire Dating Sites 2Health News:PREVENT Life Safety Ranks No. 3660 on the 2015 Inc. 5000 With Three-Year Sales Growth of 85% 2
... tailor therapy regimen to individuals, experts say , , TUESDAY, ... affect the way children respond to treatment for lymphoblastic ... children suffering from this type of blood and bone ... to treatment. Now researchers think they know why. , ...
... radiation indicates need for earlier screening, study notes, , , ... female childhood cancer survivors under the age of 40 ... are not following the recommended advice to get screening ... The recommendation suggests starting screening mammograms at age 25, ...
... Ill., Jan. 27 EngagementHealth, LLC., an innovator ... launch of its comprehensive disease prevention and health ... RBNF ). Rurban Financial is a leading ... services, and bank data and item processing, headquartered ...
... point-of-use and central pharmacy automation solutionsMOUNTAIN VIEW, Calif., Jan. ... a leading provider of system solutions to acute healthcare ... by Emory Healthcare for Omnicell point-of-use and central pharmacy ... (NASDAQ: OMCL ) is a leading provider ...
... 27, 2009 Environmental Tobacco Smoke (ETS) commonly called ... account for complications during pregnancy and birth. It is ... than do whites from smoking and ETS exposure. In ... the American Journal of Preventive Medicine , researchers ...
... Jan. 27 Trust for America,s Health (TFAH) applauds ... funding to improve the health of Americans while stimulating ... "This funding is desperately needed to revitalize and ... be putting more Americans to work in programs that ...
Cached Medicine News:Health News:In Kids, Genes May Affect Leukemia Treatment 2Health News:In Kids, Genes May Affect Leukemia Treatment 3Health News:Childhood Cancer Survivors Not Getting Recommended Mammograms 2Health News:Childhood Cancer Survivors Not Getting Recommended Mammograms 3Health News:EngagementHealth(R) Launches Comprehensive Wellness Programs With Rurban Financial Corp. (Nasdaq - RBNF) 2Health News:Avoiding secondhand smoke during pregnancy 2Health News:Trust for America's Health Applauds Public Health Funding in Senate Stimulus Bill as Down Payment for Containing Health Care Costs 2Health News:Trust for America's Health Applauds Public Health Funding in Senate Stimulus Bill as Down Payment for Containing Health Care Costs 3
... and Response catheters comprise the world's ... for electrophysiology procedures. Their advanced catheter ... superior torque response with a soft, ... and French sizes, Supreme and Response ...
... Jude Medical's line of guiding introducers ... RAMP, and 2 piece steerable, all ... catheters when the varying curves and ... physician technique. St. Jude Medical guiding ...
Novus 3000 A fully-integrated and powerful 532 nm Operating Room Photocoagulator with reliable DPSS technology and simplified operation using a touch screen interface and remote control....
... provide outstanding insertion performance, with ... high kink resistance and minimal ... sheath cannula provides optimal strength ... an extra strong dilator to ...
Medicine Products: