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Lexicon Announces Positive Results from New Clinical Study of LX4211 in Type 2 Diabetes Patients
Date:1/6/2011

astrointestinal-derived peptide hormones that have been associated with producing satiety and reducing food intake.  PYY has been studied as an anti-obesity agent, and GLP-1 is a mediator of insulin and glucagon secretion.  As nutrients enter the small intestine, PYY and GLP-1 are co-secreted into the circulation by neuroendocrine cells (L cells) of the gastrointestinal tract.

"We have established a solid tablet formulation suitable for further development and will continue to explore LX4211's unique mechanism of action in the treatment of diabetes and the hormonal control of metabolism," said Arthur T. Sands, M.D., Ph.D., president and chief executive officer. "We believe the results of this study provide further evidence that dual inhibition of SGLT1 and SGLT2 may provide enhanced glycemic control over SGLT2 inhibition alone, consistent with the remarkable results observed in our Phase 2a clinical trial of LX4211."

About the Clinical Trial

The clinical trial compared a new solid oral dose formulation of LX4211 to the liquid dose formulation used in prior clinical trials of LX4211.  The trial employed a randomized, triple-cross over design during which 12 patients with type 2 diabetes each received 300 mg of LX4211 in different dose forms.  Patients were administered a single dose of two 150 mg tablets, six 50 mg tablets or a 300 mg liquid dose formulation in varying sequences at 5-day intervals over a total period of 15 days.  Pharmacokinetic and pharmacodynamic measures were monitored at frequent time points at baseline and after administration of each of the three dose forms with baseline measures prior to dosing used as controls.

Additional details regarding the results from this latest clinical study will be presented on Monday, January 10, 2011 at the JP Morgan Healthcare Conference.  A live webcast of the presentation will be available
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SOURCE Lexicon Pharmaceuticals, Inc.
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