Navigation Links
Leukemia Drug Proves Safe and Effective Over the Long Term
Date:11/7/2007

WASHINGTON, Nov. 7, /PRNewswire-USNewswire/ -- The drug imatinib mesylate, more commonly known as Gleevec(R), proves safe and effective over the long term in patients with an advanced form of chronic myeloid leukemia (CML), according to a study prepublished online in Blood, the official journal of the American Society of Hematology.

A team of researchers from the U.S. and Europe, including the drug's creator, Brian Druker, MD, followed 454 patients with chronic-phase CML taking imatinib for more than six years. Prior to enrollment, all study participants had experienced either treatment failure or intolerance with interferon alpha, which was the standard of care for CML at the time the study was initiated.

"The long-term follow-up results of imatinib in CML post interferon failure reassure us of the high efficacy of the drug and its safety," stated Hagop Kantarjian, MD, the lead author on the study and Chairman and Professor of the Leukemia Department at the University of Texas M.D. Anderson Cancer Center. "With a six-year follow-up, the estimated six-year survival rate is 76 percent. In historical data, after interferon failure the average survival was about three to four years."

Imatinib dosage began at 400 milligrams per day and was escalated to 600 mg/d or 800 mg/d in patients who did not achieve positive treatment responses within set time periods or whose disease relapsed.

The best possible treatment outcome -- a complete cytogenetic response, which is the elimination of the genetic abnormality associated with the disease -- occurred in 57 percent of the study participants and was achieved in a median time of eight months. Overall survival rates and avoidance of disease progression were strongly correlated with cytogenetic response by 12 months; those with a minimal or no cytogenetic response within the first year faired poorly.

The incidence of serious side effects was low and, although 15 cases of heart dysfunction were reported in study participants, only four cases were considered to be drug-related. During the study, 35 patients discontinued the drug because of adverse events or abnormal test results.

"About half of the patients on the study continue to receive imatinib and 40 percent are in complete cytogenetic response," said Dr. Kantarjian. "No long-term new toxicities have been observed. In particular, the drug-related cardiac toxicity, which was reported to be of concern last year, was quite rare."

This clinical trial was the basis for the first approval of imatinib for CML, which has since become the standard of care for the disease.

The American Society of Hematology (http://www.hematology.org) is the world's largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology.

Blood, the official journal of the American Society of Hematology, is the most cited peer-reviewed publication in the field. Blood is issued to Society members and other subscribers twice per month, available in print and online at http://www.bloodjournal.org.


'/>"/>
SOURCE American Society of Hematology
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
2. CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
3. St. Jude Discovers Factors That Accelerate Resistance to Gleevec(TM) Targeted Therapy in Lymphoblastic Leukemia
4. September is Leukemia, Lymphoma and Myeloma Awareness Month
5. The Leukemia & Lymphoma Society is Encouraged by Promising News for Myeloma Patients
6. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
7. New Study Proves That Minimally Invasive Aneurysm Treatment Yields Successful Long-Term Results
8. Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study
9. FDA Approves Lillys Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women
10. First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival
11. Health Canada Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical ... and Gynecology markets with innovative and proprietary products, ... Company as Senior Vice President, Marketing & Business ... will report directly to Darin Hammers , ... delighted that Ash has joined the Cogentix team," ...
(Date:4/20/2017)... 20, 2017 Research and Markets has announced ... Driven by Rapidly Expanding Injectables Market and Increasing Usage of Complex ... ... technologies will rise from USD 20 Billion in 2015 to around ... Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and ...
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
Breaking Medicine Technology:
(Date:4/27/2017)... VA (PRWEB) , ... April 27, 2017 , ... ... application containerization, today announced an exhibitor sponsorship at MobileIron Live! 2017 ... and new technologies for an immersive, educational approach to helping organizations maximize the ...
(Date:4/27/2017)... , ... April 27, 2017 , ... Offering the purest ... an oil many times purer and more potent than the market has seen before. ... Gstaad, Switzerland, as well as a patented chromatography process for extraction, to produce its ...
(Date:4/27/2017)... ... April 27, 2017 , ... Plastic Surgery Associates is excited to announce that ... at the upcoming Aesthetic Meeting. Held in San Diego, at the San Diego Convention ... will lend their expertise to the Premier Global Hot Topics session, speaking on genital ...
(Date:4/26/2017)... Louis, Missouri (PRWEB) , ... April 26, 2017 ... ... cost, quality and clinical outcomes, today released the podcast, “Make Plans for ... in bringing value-based payment into the physician's office and how physicians and other ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... ATA 2017 President’s Awards recipients, comprised of organizations and individuals who have ... , The ATA 2017 President’s Awards recognize individuals and organizations on the ...
Breaking Medicine News(10 mins):