Navigation Links
Leukemia Drug Proves Safe and Effective Over the Long Term
Date:11/7/2007

WASHINGTON, Nov. 7, /PRNewswire-USNewswire/ -- The drug imatinib mesylate, more commonly known as Gleevec(R), proves safe and effective over the long term in patients with an advanced form of chronic myeloid leukemia (CML), according to a study prepublished online in Blood, the official journal of the American Society of Hematology.

A team of researchers from the U.S. and Europe, including the drug's creator, Brian Druker, MD, followed 454 patients with chronic-phase CML taking imatinib for more than six years. Prior to enrollment, all study participants had experienced either treatment failure or intolerance with interferon alpha, which was the standard of care for CML at the time the study was initiated.

"The long-term follow-up results of imatinib in CML post interferon failure reassure us of the high efficacy of the drug and its safety," stated Hagop Kantarjian, MD, the lead author on the study and Chairman and Professor of the Leukemia Department at the University of Texas M.D. Anderson Cancer Center. "With a six-year follow-up, the estimated six-year survival rate is 76 percent. In historical data, after interferon failure the average survival was about three to four years."

Imatinib dosage began at 400 milligrams per day and was escalated to 600 mg/d or 800 mg/d in patients who did not achieve positive treatment responses within set time periods or whose disease relapsed.

The best possible treatment outcome -- a complete cytogenetic response, which is the elimination of the genetic abnormality associated with the disease -- occurred in 57 percent of the study participants and was achieved in a median time of eight months. Overall survival rates and avoidance of disease progression were strongly correlated with cytogenetic response by 12 months; those with a minimal or no cytogenetic response within the first year faired poorly.

The incidence of serious side effects was low and, although 15 cases of heart dysfunction w
'/>"/>

SOURCE American Society of Hematology
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
2. CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
3. St. Jude Discovers Factors That Accelerate Resistance to Gleevec(TM) Targeted Therapy in Lymphoblastic Leukemia
4. September is Leukemia, Lymphoma and Myeloma Awareness Month
5. The Leukemia & Lymphoma Society is Encouraged by Promising News for Myeloma Patients
6. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
7. New Study Proves That Minimally Invasive Aneurysm Treatment Yields Successful Long-Term Results
8. Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study
9. FDA Approves Lillys Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women
10. First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival
11. Health Canada Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 A six-hour certification program on ... presented at the Cannabis World Congress & Business Exposition ... York, NY .  Taking place on Wednesday, June 17 ... of education at the leading event on the East Coast ... Led by Clover Leaf University, the first cannabis university to ...
(Date:5/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hgs483/cardiovascular ) ... report "Cardiovascular Drug Delivery - Technologies, Markets ... Drug delivery to the cardiovascular system is different ... anatomy and physiology of the vascular system; it ... the body. Drugs can be introduced into the ...
(Date:5/29/2015)... Research and Markets ( ... "Surgical/Operating Microscopes Market by Application & End ... to their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... poised to reach $806.6 million by 2020 from ... 12.3% from 2015 to 2020. , ,Major factors ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 2Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 3Surgical/Operating Microscopes Market by Application & End User - Global Forecast to 2020 for the $806 Million Industry 2
... 2011 Zimmer Holdings, Inc. (NYSE: ZMH ; ... the Zimmer NexGen LPS-Flex Mobile Bearing ... the United States.  The LPS-Flex Mobile Bearing knee provides a ... cruciate ligament (ACL), replicating the anatomic center of knee rotation. ...
... Reportlinker.com announces that a new market research ... Merck & Co., Inc.: PharmaVitae Profile ... IntroductionThis analysis examines the historical and forecast performance ... sector. The profile encompasses global company strategy, portfolio ...
Cached Medicine Technology:Zimmer Introduces a Move Forward in Mobile Bearing Knee Design 2Zimmer Introduces a Move Forward in Mobile Bearing Knee Design 3Reportlinker Adds Merck & Co., Inc.: PharmaVitae Profile 2
(Date:5/29/2015)... 29, 2015 The science of hair ... Angeles thanks to the efforts of internationally recognized hair ... combined ARTAS hair restoration and manual FUE ... procedures available anywhere. , A Follicular Unit Extraction ... harvesting hair follicle grafts from the donor areas of ...
(Date:5/29/2015)... CO (PRWEB) May 29, 2015 ... new addiction, substance abuse, and co-occurring mental health ... and ribbon cutting for the general public on ... 2nd. , The Recovery Village at Palmer Lake ... intensive outpatient programming, utilizing traditional and evidence-based therapies, ...
(Date:5/29/2015)... 29, 2015 Red Hot & Blue ... Red Hot & Blue restaurant at 525 New Waverly Place ... 7, 2015. “The Red Hot & Blue Restaurant was previously ... but we have moved to a new location in the ... middle of all the activities on the Promenade–with outdoor seating ...
(Date:5/29/2015)... 2015 A group of doctors have discovered ... national effort to teach this “new math” to children in ... been “sickened” by the recent implementation of Common Core Math ... it, Common Core is now a reality in children’s classrooms ... are now seeking ways to improve common core math training ...
(Date:5/29/2015)... has joined forces with Raw Elements Physical Eco Protection ... sun protection. The print component of “Skin Health” is ... 250,000 copies and an estimated readership of 750,000 readers. ... social media strategy, and across a network of top ... version of the campaign, click here . ...
Breaking Medicine News(10 mins):Health News:Los Angeles and Beverly Hills Hair Transplant Doctor Now Combines Robotic Hair Restoration (ARTAS) and Manual FUE Transplants for Maximum Hair Coverage 2Health News:Advanced Recovery Systems Announces the Opening of The Recovery Village at Palmer Lake 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 3Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 4Health News:Doctors Discover a Cure for the Common Core 2
... advanced colorectal neoplasms was lower in participants in a ... received a colonoscopy in the preceding 10 years, according ... the Journal of the National Cancer Institute . ... been studied, but evidence from community settings is sparse, ...
... untreated, plantar fasciitis can lead to other problems, doctor says ... injuries" may bring to mind tennis elbow and jogger,s knee, ... of injury due to overuse, doctors warn. , The condition, ... of the foot, can become chronic if steps aren,t taken ...
... in otherwise healthy nonsmoking adults, study finds , WEDNESDAY, ... smokers face a higher risk of early emphysema when ... totally recovered from secondhand smoke exposure, new research suggests. ... scans on 1,781 non-smokers from six communities in the ...
... , WASHINGTON, Dec. 30 BIO Ventures for ... Chief Executive Officer of the global health non-profit. Moree has ... July 2009 and has been a member of the board of ... for Global Health as interim CEO, she served as Executive Director ...
... although legal, and adults use it widely to perk themselves ... But how strong is caffeine,s appeal in ... What impact does acute and chronic caffeine consumption have on ... does consuming caffeinated drinks during adolescence contribute to later use ...
... one day take potent therapies, get heart fixed later, researchers ... types of chemotherapy can damage the heart while thwarting cancer, ... new study in rats finds that injecting the heart with ... anti-cancer drug. , , The findings could one day mean ...
Cached Medicine News:Health News:Fewer left-sided colorectal tumors observed after colonoscopies 2Health News:Heel Pain Usually Relieved With Stretching Regimen 2Health News:BIO Ventures for Global Health Announces New CEO 2Health News:BIO Ventures for Global Health Announces New CEO 3Health News:Addictive effects of caffeine on kids being studied by UB neurobiologist 2Health News:Addictive effects of caffeine on kids being studied by UB neurobiologist 3Health News:Stem Cells Might Reverse Heart Damage From Chemo 2Health News:Stem Cells Might Reverse Heart Damage From Chemo 3
Catalano curved tying forcep has 6 mm V-grove tying platform. Overall length 100 mm....
Kelman - McPherson tying forceps with serrated handle, platform 4 mm and overall length of 85 mm....
Troutman tying forceps are curved, delicate, bullet shape, with tying platforms. Flat pattern. Ultra fine platforms ideal for 10-0 or 11-0 suture material. Platforms fully meet to hold suture firmly....
Helveston tying forceps, standard with smooth jaws. For 4-0 to 6-0 sutures....
Medicine Products: