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Lentigen and UH Case Medical Center Initiate Phase I Trial Using Gene Therapy and Bone Marrow Stem Cells in the Treatment of Brain Cancer
Date:11/14/2011

rofessor of Neurological Surgery and Pathology at Case Western Reserve University School of Medicine, who is leading the clinical trial.  "This trial has the potential to change the way we treat GBM -- particularly in patients whose bone marrow is sensitive or those whose tumors are likely to be resistant to standard therapies."  

The LG631 vector was designed by Lentigen Corporation, a biotechnology company specializing in the development and manufacture of Lentiviral gene delivery technologies,  and has been evaluated in animal models in collaboration with Stanton Gerson, MD, Director of the Case Comprehensive Cancer Center at Case Western Reserve University and Seidman Cancer Center at UH Case Medical Center. The application of the mutated MGMT gene for use in stem cell protection was discovered in Dr. Gerson's laboratory.

"The combination of the vector technology with the stem cell gene therapy approach is highly innovative," says Dr. Gerson. "This is the first time the combination will be used in cancer patients right after surgery.  We are excited about this promising approach to enhance current treatments for glioblastoma."

"The initiation of this NCI-supported study represents an important milestone in the development of Lentigen's pipeline," said Tim Ravenscroft, CEO of Lentigen Corporation.  "It is the first of several products which we expect to enter the clinic in the next 12 months.  For patients with glioblastoma treated with Temodar, it is our hope that LG631 gene therapy of bone marrow stem cells can substantially improve patient outcomes in this devastating disease."  

The project described was supported by Grant Number R42CA128269 from the National Cancer Institute and a grant to the Center for Stem Cell & Regenerative Medicine (CSCRM) from Ohio's Third Frontier Commission under its Research Commercialization Program. The content is solely the responsibility of the authors and doe
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