Navigation Links
Lentigen and UH Case Medical Center Initiate Phase I Trial Using Gene Therapy and Bone Marrow Stem Cells in the Treatment of Brain Cancer
Date:11/14/2011

CLEVELAND and GAITHERSBURG, Md., Nov. 14, 2011 /PRNewswire/ -- University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced today the initiation of a novel Phase I clinical trial of LG631 gene therapy for the protection of hematopoietic stem cells (HSCs) from the dose limiting toxicity of chemotherapy with Temodar.  

Approximately 17,000 Americans are diagnosed with glioblastoma every year and only two percent of them survive longer than five years -- even with aggressive treatment.  Glioblastoma (GBM) treatment generally begins with a surgical resection, followed by radiation therapy and then chemotherapy to destroy any remaining cancer cells.  Temodar (temozolomide, Merck and Co., Inc.) is a standard treatment of glioblastoma, but dose-limiting bone marrow toxicity often accompanies such therapy.

In this first-of-its-kind study, researchers are investigating if LG631 can potentially improve tolerance and effectiveness of chemotherapy for GBM by preventing damage to bone marrow. The study will evaluate the safety of this treatment and its potential to enhance current GBM treatments.

For this study, HSCs will be isolated from participating patients, transduced with LG631, an altered human-Methylguanine Methyltransferase (MGMT) gene to make them resistant to Temodar, and then infused back into the patient.  The MGMT gene has been shown to repair damaged DNA. The specially designed Lentiviral vector (LG631) will be used to deliver the gene specifically to bone marrow stem cells that are susceptible to damage by drugs commonly used to treat cancer, thereby enabling patients to receive higher doses of Temodar with less severe side effects.

"Glioblastoma is a devastating disease and many patients do not benefit from standard therapy," notes Dr. Andrew Sloan, Director of the Brain Tumor and Neuro-Oncology Center, UH Case Medical Center and Associate P
'/>"/>

SOURCE Lentigen Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lentigen Awarded Phase I SBIR Grant for Hepatitis C Vaccine
2. University Hospitals Case Medical Center Researchers Search for Mysteries of Dystonia With Advanced Brain Imaging
3. Dehaier Medical to Participate in MEDICA 2011 in Dusseldorf, Germany from November 16-19, 2011
4. Dehaier Medical Announces Record Third Quarter 2011 Financial Results
5. OncoSec to Present at Medical Device Investor Forum
6. Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results
7. Cheyenne Regional Medical Center Announces New Air Ambulance Service Partnership with HealthONEs AirLife Denver
8. Panasonic Unveils Relationship with Cenegenics Medical Institute Featuring CardioHealth Station
9. Winner Medical to Participate in Upcoming Investor Conferences in China
10. Shands Jacksonville Medical Center Converts to Masimo rainbow SET for State-of-the-Art Noninvasive Patient Monitoring Capabilities
11. Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014  IBM (NYSE: IBM ... ( DESY ), a leading national research center in ... and storage of massive volumes of x-ray data. The ... on IBM software defined technology can handle more than ... and help scientists worldwide gain faster insights into the ...
(Date:8/21/2014)... -- Seventy-one percent of Americans believe the abuse of strong prescription ... and safety issue in the United States ... Repass & Partners, a Cincinnati based ... of the prescription medication abuse problem and the need for ... situation facing our country," Rex Repass , CEO of ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... Health Organization has issued a warning to medical travelers: ... heels of a growing threat of an antibiotic-resistant superbug, ... the region in India where it was discovered. "Many ... or knee replacements, ACL surgeries, root canals and spinal ...
...  Neuro Kinetics, Inc. (NKI) ( www.neuro-kinetics.com ), manufacturers ... test for vestibular and neurological conditions, said today ... control and analysis software at the upcoming annual ... Boston ( http://am2010.entnet.org/ ). NKI will ...
Cached Medicine Technology:New York Plastic Surgery News: Medical Tourists Beware of Drug-Resistant Superbug NDM-1 2Neuro Kinetics to Showcase Enhanced Control & Analysis Software at Otolaryngology Conference 2
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... developed by Dr. Sen and Dr. Samantha Pearson to ... glasses, contacts, and avoid corrective vision surgery by instead ... Shane Michaels, prompting an investigative review. , “There’s ... billions of dollars in revenue each year—it’s because people ...
(Date:8/22/2014)... August 22, 2014 Testosterone treatment ... in U.S. courts on behalf of men who ... use of prescription low testosterone therapies, Bernstein Liebhard ... claim was filed against Pfizer Inc. on July ... life-threatening heart issues due to his use of ...
(Date:8/22/2014)... du Sac, Wisconsin (PRWEB) August 22, 2014 ... PFTape™ System for Plantar Fasciitis, an exciting new product ... product allows you to stay active while you heal. ... application. This is truly a new technology – it ... and affordable. , FasciaDerm® PFTape™ System for Plantar ...
(Date:8/22/2014)... The improved access to antiretroviral drugs and treatments ... has led to the decline in the rate of ... AIDS globally. However, despite the fact that HIV infection ... affected by the virus is on the rise. With ... organisations and stakeholders, by 2015, significant investments are expected ...
(Date:8/22/2014)... News) -- Back-to-school time provides an opportunity for parents ... family schedules, an expert suggests. "Forget New Year,s ... also be the start of a new fitness and ... kinesiology at the University of the Sciences in Philadelphia, ... extracurricular activities likely to build up, "it,s important for ...
Breaking Medicine News(10 mins):Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 3Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 4Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:With Kids in School, Parents Can Work Out 2
... HealthDay Reporter , WEDNESDAY, Jan. 5 (HealthDay News) ... with standard care, omega-3 fatty acid supplements appear to ... "Adding n-3 polyunsaturated fatty acids, even in patients ... a further improvement in heart function and exercise capacity," ...
... WEDNESDAY, Jan. 5 (HealthDay News) -- Women with multiple sclerosis ... a gene thought to be connected to the condition, a ... gain more insight into the development of MS, which is ... women. Although no one knows what causes MS, scientists suspect ...
... By Alan Mozes HealthDay Reporter , ... suggests that cocaine addiction might be treatable with a ... common cold virus in combination with a cocaine-like substance ... vaccine appears to provoke an effective and long-lasting antibody ...
... RI When methicillin-resistant S. aureus (MRSA) is ... for an invasive infection, including a surgical site infection. Some ... in the nose, the greater the risk of transmission to ... Few studies to date have assessed the differences in quantity ...
... 2011A new, simplified method for producing large amounts of ... cells will help advance the promising field of gene ... human clinical trials. The novel adeno-associated virus (AAV) production ... ahead of publication in Human Gene Therapy , ...
... News) -- Stress can cause even a healthy cat to ... researchers found that healthy cats were just as likely as ... waste outside their litter box if there was a change ... or caretaker. The healthy cats were compared to cats ...
Cached Medicine News:Health News:Fish Oil May Help Some Heart Failure Patients 2Health News:Fish Oil May Help Some Heart Failure Patients 3Health News:Study Sheds Light on Genetic Risk of MS 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 2Health News:Vaccine Protects Mice From Cocaine's Effects, Study Finds 3Health News:Where MRSA colonizes on the human body 2Health News:Faster, scalable method for producing AAV-based gene transfer vectors 2
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... The Research pro Electronic Pipette is ideal ... laboratory. Its easy-to-follow display, ergonomically-placed operating buttons, ... dispensing, reverse pipetting and diluting make this ... simple functions of a manual pipette without ...
... a 384 Well Plate at Once , To ... you need a pipettor that can adapt to ... get with our 16-channel Impact pipettor., Available with ... was specifically designed to allow you to transfer ...
Medicine Products: