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Launch of Highly Targeted Cancer Treatment Tasigna(R) (nilotinib) Offers Potential Lifeline to Ph+ CML Patients Intolerant or Resistant to Existing Therapies, Including Glivec(R) (imatinib)
Date:5/19/2008

s with Tasigna(R)(2).

Tasigna(R) works quickly in patients who have undergone other therapies, laboratory trials have shown it is effective in 32 out of 33 known imatinib resistant mutant cell lines.(3)

Tasigna trialist, Professor Richard Clark, Consultant Haematologist at Royal Liverpool University Hospital said:

"Running out of treatment options is a terrible scenario for any patient with CML, a disease where the prognosis has not always been good. The arrival of Tasigna(R) is a major step forward for those patients that do not respond to existing treatments. To be able to offer patients a reliable and effective option with a good safety profile is a significant advance in the treatment of CML."

CML is one of the four most common leukaemias in the world affecting 4000 people in the UK(4) Most people with CML can be treated in the long term with Glivec (imatinib) but a small amount of people, estimated at 3% per year cannot take Glivec(R) because of intolerance or because their cancer mutates and becomes resistant to Glivec(R)(5) Tasigna(R) offers an effective and well tolerated treatment option to the majority of people with imatinib resistant CML.

Sandy Craine, CML Support UK, welcomes the launch of Tasigna:

"Tasigna is an important advance as it provides an effective treatment option for the small number of CML patients who develop resistance to or are intolerant of Glivec. Glivec signified a revolution in the way we think about treating cancers and has proven to be very effective in the long term. Tasigna offers patients resistant or intolerant to previous therapies the chance to regain control of their health and continue to live normal and productive lives."

References

(1). Kantarjian, H et al. Nilotinib is Highly Active and Safe in Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Patients with Imatinib-resistance or Intolerance. Oral Presentation. American Society of Hematology Annual Meeting, 2007.
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SOURCE Novartis Pharmaceuticals UK Ltd
Copyright©2008 PR Newswire.
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