Navigation Links
Latest Cell Publication Describes the Novel Kinase Regulators Using OriGene's Functional Kinome Collection

ROCKVILLE, Md., May 5th /PRNewswire/ -- Scientists from University of Helsinki, Institute of Molecular Medicine in Finland and OriGene Technologies joined effort in creating the most comprehensive kinome collection of nearly all predicted human protein kinases, including the functional kinases and their kinase-deficient counterparts. Equipped with this collection, the authors successfully identified novel kinase regulators in Hedgehog signaling pathway and in activation of Karposi's Sarcoma herpesvirus. The results are published in the May 2nd issue of Cell, titled "Application of active and kinase-deficient kinome collection for identification of kinase regulating Hedgehog signaling."

The uniqueness of the study lies in the kinome expression screening approach in interrogating the gene functions in biological pathways. Screening the collection in a cell-culture model of Hedgehog signaling pathway, the authors were able to quickly identify two novel regulator kinases, DYRK2 and MAP3K10. The study demonstrated the kinome collection as a powerful tool for systematic and quantitative analysis of signaling cross-talk and identification of novel regulatory kinases.

"The isolated kinase genes form a resource that scientists can now use to systematically map kinase signaling networks in different cellular disease models," stated Professor Taipale, senior author of the article. "The kinases are also promising targets for therapeutic intervention in the treatment various cancers."

"OriGene is proud to be a contributor to this exciting research. The study provides another proof-of-principle of using a large collection of over-expression cDNA clones to decipher gene functions in biological pathways," said Dr. Zairen Sun, VP of R&D at OriGene. "We are excited that scientists are taking advantage of such collection to accelerate their research. We hope this publication will serve as a tutorial for those who wish to try large-scale biology."

OriGene's TrueClone collection of over 20,000 unique cDNA clones has empowered multiple pioneering groups to discover novel genes in major pathways through genome-scale biology. The Cell publication further validated the value of the TrueClone collection. The comprehensiveness of the collection and the expression-readiness of the cDNA clones make it the ideal source for high-throughput functional screening. To make the collection more accessible and assay-ready, OriGene now offers the convenient Kinome GFC (Genome wide Full-length cDNA) Transfection Array.

About OriGene Technologies

Since 1996, OriGene has been dedicated in creating TrueClone, the largest full-length cDNA collection for gene function study. OriGene's flagship products are the TrueClone Collection, a searchable source of over 33,000 human full-length cDNA clones suitable for transfection and protein expression and TrueORF clones of over 25,000 tagged human ORF clone. More information about OriGene Technologies, the GFC Tranfection Array of cDNA clones and other products can be found at the company's website

SOURCE OriGene Technologies Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
4. Medifast, Inc. Announces Acceptance for Publication of Clinical Efficacy Study
5. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
6. PTC Therapeutics Announces Publication of Preclinical Data in PNAS
7. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
8. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
9. Industry Executives Finding Value in Shift of Scientific Publications
10. OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye Infection
11. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
Post Your Comments:
(Date:11/26/2015)... India , November 27, ... --> --> ... personal emergency response system (PERS) ... steadily for 5 years with ... region expected to see a ...
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
(Date:11/26/2015)... 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in the ... Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new 247-page ... therapeutic drug monitoring market, including emerging tests, technologies, ...
Breaking Medicine Technology:
(Date:11/26/2015)... ... November 26, 2015 , ... ... Representative. As a franchise owner, Somu now offers travelers, value and care based ... packages, private cruise sales, as well as, cabin upgrades and special amenities such ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
(Date:11/25/2015)... ... 2015 , ... The holiday season is jam-packed with family ... of attendees is of the utmost importance. Whether you are cooking at home ... recipes a try this holiday season. , Turkey Croquettes ,     Ingredients: ...
(Date:11/25/2015)... ... November 26, 2015 , ... ... European Union (EU), ANDI Pan African Centres of Excellence, and public R&D institutions, ... (UNON) for the opening of the 5th African Network for Drugs and Diagnostics ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would ... OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE ... Cleveland, OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli ...
Breaking Medicine News(10 mins):