Navigation Links
Latest Cell Publication Describes the Novel Kinase Regulators Using OriGene's Functional Kinome Collection
Date:5/5/2008

ROCKVILLE, Md., May 5th /PRNewswire/ -- Scientists from University of Helsinki, Institute of Molecular Medicine in Finland and OriGene Technologies joined effort in creating the most comprehensive kinome collection of nearly all predicted human protein kinases, including the functional kinases and their kinase-deficient counterparts. Equipped with this collection, the authors successfully identified novel kinase regulators in Hedgehog signaling pathway and in activation of Karposi's Sarcoma herpesvirus. The results are published in the May 2nd issue of Cell, titled "Application of active and kinase-deficient kinome collection for identification of kinase regulating Hedgehog signaling."

The uniqueness of the study lies in the kinome expression screening approach in interrogating the gene functions in biological pathways. Screening the collection in a cell-culture model of Hedgehog signaling pathway, the authors were able to quickly identify two novel regulator kinases, DYRK2 and MAP3K10. The study demonstrated the kinome collection as a powerful tool for systematic and quantitative analysis of signaling cross-talk and identification of novel regulatory kinases.

"The isolated kinase genes form a resource that scientists can now use to systematically map kinase signaling networks in different cellular disease models," stated Professor Taipale, senior author of the article. "The kinases are also promising targets for therapeutic intervention in the treatment various cancers."

"OriGene is proud to be a contributor to this exciting research. The study provides another proof-of-principle of using a large collection of over-expression cDNA clones to decipher gene functions in biological pathways," said Dr. Zairen Sun, VP of R&D at OriGene. "We are excited that scientists are taking advantage of such collection to accelerate their research. We hope this publication will serve as a tutorial for those who wish to try large-scale biology." '/>"/>

SOURCE OriGene Technologies Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
4. Medifast, Inc. Announces Acceptance for Publication of Clinical Efficacy Study
5. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
6. PTC Therapeutics Announces Publication of Preclinical Data in PNAS
7. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
8. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
9. Industry Executives Finding Value in Shift of Scientific Publications
10. OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye Infection
11. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 10, 2014   LabStyle Innovations Corp ... today announced the appointment of Professor Richard ... its Board of Directors. Prof. Stone ... experience to LabStyle as an entrepreneur, venture capitalist ... corporate governance expert. He currently serves on the ...
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... WASHINGTON , Jan. 15, 2014 AARP Foundation today ... support older adults suffering from the severe cold weather that ... are committed to helping those in need; so to support ... dollar-for-dollar contributions up to $250,000, which could mean up to ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
(Date:7/11/2014)... 2014 Superior Labs announce the launch ... supplements to aid in maintaining optimal digestive health by ... metabolism of fat. Formulated and manufactured in the U.S ... is available in all-natural, vegetarian capsules, with each capsule ... Health Benefits of Artichoke Leaf Extract , Superior Labs ...
(Date:7/11/2014)... TN (PRWEB) July 11, 2014 This morning(July ... Fox 13--Good Morning Memphis to discuss the illegal immigration crisis ... border town of McAllen, Texas. , Dr. Flinn told Good ... it is absolutely wide open… The problem is that they ... influx. Thousands of people per day are coming into the ...
(Date:7/11/2014)... July 11, 2014 Yisrayl Hawkins, Pastor and ... a letter pleading to let the children from other nations, ... allowed to come. Yisrayl says President Barack Obama is fighting ... the United States, and he wants to help him. ... from Guatemala, Honduras and El Salvador being treated as if ...
(Date:7/11/2014)... 2014 Shu Cosmetic Surgery announces ... each qualifying patient undergoing a laser vaginal ... laser vaginal rejuvenation, an advanced type of vaginal ... procedure decreases the internal and external diameters of ... strength, and control, resulting in enhanced sexual gratification ...
(Date:7/11/2014)... TX (PRWEB) July 11, 2014 Based ... urgent care to residents of Brazoria County and surrounding ... that the clinic is now accessible from Northbound Highway ... as a center where patients can get low-cost urgent ... are far from rare, finding places that can match ...
Breaking Medicine News(10 mins):Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 2Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 3Health News:Senate Candidate, George Flinn on Fox13 NEWS About the Border Crisis 2Health News:Yisrayl Hawkins Backs Barack Obama’s Pleas to Let the Children Come to the U.S. in New Letter 2Health News:Yisrayl Hawkins Backs Barack Obama’s Pleas to Let the Children Come to the U.S. in New Letter 3Health News:Shu Cosmetic Surgery of Twin Cities Now Offers Complimentary Perineoplasty in Laser Vaginal Rejuvenation 2Health News:Shu Cosmetic Surgery of Twin Cities Now Offers Complimentary Perineoplasty in Laser Vaginal Rejuvenation 3Health News:Prime Urgent Care Announces New Access to the Clinic, Available from Northbound Highway 288 2
... , , KIBBUTZ SHAMIR, ... SHMR ) (" Shamir ") expects to issue its second quarter ... a conference call to discuss the results at 11:00 A.M. EDT that ... broadcast live as a listen-only webcast. To listen live, please go to ...
... , , BETHESDA, Md., Aug. 6 ... developing novel, proprietary antibodies for the treatment of cancer, inflammation ... second quarter and six months ended June 30, 2009. , ... Micromet achieved a number of significant milestones illustrating its continued ...
... revised higher based on solid year-to-date performance and, positive ... Aug. 6 /PRNewswire-FirstCall/ - SXC Health Solutions Corp. ("SXC" or the "Company") ... the three- and six-month periods ended June 30, 2009. Financial references are ... Q2 2009 Highlights, ------------------, - ...
... , , WILMINGTON, Mass., Aug. 6 DUSA Pharmaceuticals, ... highlights and second quarter financial results press release will be issued on Tuesday, August ... , , Tuesday, August 11 - 8:30 a.m. E.T. , ... 800.647.4314 , Password - DUSA , , ...
... ... two additional contracts to the RTP, NC-based life sciences company Entegrion, ... safety and availability of blood-derived products for treating combat injuries. ... essential in responding to traumatic injury, especially on the battlefield. ...
... , ... plans provided by GetOnlineQuotes.com offer the best value in the current marketplace. , ... Miami, FL (PRWEB) August ... by law, the AARP Medicare Supplement ( http://www.getonlinequotes.com/aarp-medicare-insurance.html ) rates offered by ...
Cached Medicine News:Health News:Shamir Optical Industry Ltd. to Host Conference Call Announcing Second Quarter of 2009 Earnings Results 2Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 2Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 3Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 4Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 5Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 6Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 7Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 8Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 9Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 10Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 11Health News:SXC Health solutions announces record second quarter financial results 2Health News:SXC Health solutions announces record second quarter financial results 3Health News:SXC Health solutions announces record second quarter financial results 4Health News:SXC Health solutions announces record second quarter financial results 5Health News:SXC Health solutions announces record second quarter financial results 6Health News:SXC Health solutions announces record second quarter financial results 7Health News:SXC Health solutions announces record second quarter financial results 8Health News:SXC Health solutions announces record second quarter financial results 9Health News:SXC Health solutions announces record second quarter financial results 10Health News:SXC Health solutions announces record second quarter financial results 11Health News:SXC Health solutions announces record second quarter financial results 12Health News:SXC Health solutions announces record second quarter financial results 13Health News:SXC Health solutions announces record second quarter financial results 14Health News:SXC Health solutions announces record second quarter financial results 15Health News:SXC Health solutions announces record second quarter financial results 16Health News:SXC Health solutions announces record second quarter financial results 17Health News:SXC Health solutions announces record second quarter financial results 18Health News:SXC Health solutions announces record second quarter financial results 19Health News:U.S. Navy Awards Entegrion Contracts for $4 Million for the Development of Critical Blood Products 2Health News:U.S. Navy Awards Entegrion Contracts for $4 Million for the Development of Critical Blood Products 3Health News:GetOnlineQuotes.com to Offer AARP/United Healthcare Medicare Supplement Insurance to Florida Residents 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: