Navigation Links
Latest Cell Publication Describes the Novel Kinase Regulators Using OriGene's Functional Kinome Collection
Date:5/5/2008

ROCKVILLE, Md., May 5th /PRNewswire/ -- Scientists from University of Helsinki, Institute of Molecular Medicine in Finland and OriGene Technologies joined effort in creating the most comprehensive kinome collection of nearly all predicted human protein kinases, including the functional kinases and their kinase-deficient counterparts. Equipped with this collection, the authors successfully identified novel kinase regulators in Hedgehog signaling pathway and in activation of Karposi's Sarcoma herpesvirus. The results are published in the May 2nd issue of Cell, titled "Application of active and kinase-deficient kinome collection for identification of kinase regulating Hedgehog signaling."

The uniqueness of the study lies in the kinome expression screening approach in interrogating the gene functions in biological pathways. Screening the collection in a cell-culture model of Hedgehog signaling pathway, the authors were able to quickly identify two novel regulator kinases, DYRK2 and MAP3K10. The study demonstrated the kinome collection as a powerful tool for systematic and quantitative analysis of signaling cross-talk and identification of novel regulatory kinases.

"The isolated kinase genes form a resource that scientists can now use to systematically map kinase signaling networks in different cellular disease models," stated Professor Taipale, senior author of the article. "The kinases are also promising targets for therapeutic intervention in the treatment various cancers."

"OriGene is proud to be a contributor to this exciting research. The study provides another proof-of-principle of using a large collection of over-expression cDNA clones to decipher gene functions in biological pathways," said Dr. Zairen Sun, VP of R&D at OriGene. "We are excited that scientists are taking advantage of such collection to accelerate their research. We hope this publication will serve as a tutorial for those who wish to try large-scale biology."

OriGene's TrueClone collection of over 20,000 unique cDNA clones has empowered multiple pioneering groups to discover novel genes in major pathways through genome-scale biology. The Cell publication further validated the value of the TrueClone collection. The comprehensiveness of the collection and the expression-readiness of the cDNA clones make it the ideal source for high-throughput functional screening. To make the collection more accessible and assay-ready, OriGene now offers the convenient Kinome GFC (Genome wide Full-length cDNA) Transfection Array.

About OriGene Technologies

Since 1996, OriGene has been dedicated in creating TrueClone, the largest full-length cDNA collection for gene function study. OriGene's flagship products are the TrueClone Collection, a searchable source of over 33,000 human full-length cDNA clones suitable for transfection and protein expression and TrueORF clones of over 25,000 tagged human ORF clone. More information about OriGene Technologies, the GFC Tranfection Array of cDNA clones and other products can be found at the company's website http://www.origene.com/.


'/>"/>
SOURCE OriGene Technologies Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
4. Medifast, Inc. Announces Acceptance for Publication of Clinical Efficacy Study
5. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
6. PTC Therapeutics Announces Publication of Preclinical Data in PNAS
7. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
8. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
9. Industry Executives Finding Value in Shift of Scientific Publications
10. OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye Infection
11. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... Calif. , May 23, 2017  Leaf ... most innovative medical devices for pressure ulcer prevention, ... the American Association of Critical Care Nurses, National ... May 22-25. The Leaf Patient Monitoring ... specifically for the hospital environment.  The system seamlessly ...
(Date:5/22/2017)... Fla. , May 22, 2017  As ... as a whole continue to make the revolutionary ... becomes increasingly important for ensuring positive patient outcomes ... industry stakeholders are shifting focus away from clinical ... and effects of long-term specialty drug therapy utilization ...
(Date:5/18/2017)... N.J. , May 17, 2017  Bayer announced ... oncology portfolio will be presented at the 53 rd ... Oncology (ASCO), taking place June 2-6 in ... presented at ASCO span prostate, colorectal, liver and thyroid ... analysis from the Phase II CHRONOS-1 trial of copanlisib ...
Breaking Medicine Technology:
(Date:5/27/2017)... ... May 26, 2017 , ... A May 8 article on CBCNews ... or respiratory issues that are not responsive to antibiotics nevertheless obtain prescriptions for them. ... largely responsible for the problem both in Canada and the United States. Dr. Michael ...
(Date:5/27/2017)... , ... May 27, 2017 , ... In any business, ... of the talent of your dental team at presenting treatment, there will always be ... a lot of time and money on best practices when it comes to presenting ...
(Date:5/27/2017)... Rosa, CA (PRWEB) , ... May 27, 2017 , ... ... cause for concern, but a new study from the Osteoarthritis Initiative shows ... to developing knee osteoarthritis. Knowing this in advance may give doctors the opportunity to ...
(Date:5/26/2017)... ... May 26, 2017 , ... The ... to review more than eighty-nine grant submissions all vying for nearly $1,000,000 in ... the Parkinson’s field.     , The American Parkinson Disease Association (APDA) is focused on ...
(Date:5/26/2017)... ... 26, 2017 , ... The Radiology Business Management Association ... current legislative activity and the latest regulatory concerns impacting RBMA members. The Legislative ... and will continue through Monday, Sept. 11, at the Ritz-Carlton, Tysons Corner in ...
Breaking Medicine News(10 mins):