Navigation Links
Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting
Date:12/6/2008

appears to improve endothelial dysfunction -- the inability of blood vessels to dilate properly -- in patients with sickle cell disease.

Tetrahydrobiopterin, an essential enzyme involved in the production of nitric oxide, plays a key protective role in the cardiovascular system. In patients with sickle cell disease, inflammation and production of superoxide (a highly reactive form of oxygen) in blood vessels may decrease levels of tetrahydrobiopterin, creating a deficiency. Restoring tetrahydrobiopterin levels could potentially improve endothelial function, alleviating this complication associated with sickle cell disease.

A total of 27 patients with sickle cell disease were treated every four weeks with escalating doses of tetrahydrobiopterin (2.5, 5, 10, and 20 mg/kg/day). The primary endpoint of the study was the overall safety and efficacy of tetrahydrobiopterin as measured by a non-invasive fingertip test (PAT) that scores endothelial dysfunction. A value of less than or equal to 1.67 represents endothelial dysfunction. At the start of the study, 18 patients had abnormal mean PAT scores (1.33 ± 0.17) and nine patients had normal mean PAT scores (2.09 ± 0.31).

More than one-third (67 percent) of patients with abnormal PAT scores achieved statistically significant dose-dependent improvements in endothelial dysfunction over 16 weeks of tetrahydrobiopterin treatment (2.5 mg/kg: 24 percent improvement; 5mg/kg: 31.2 percent improvement; 10 mg/kg: 39.9 percent improvement; and, 20 mg/kg: 56.6 percent improvement). Patients with normal PAT scores showed no improvement with therapy, which is consistent with the mechanism of action of tetrahydrobiopterin.

This was designed as a safety study, and additional studies in larger numbers of patients will be needed to confirm these preliminary data on the use of tetrahydrobiopterin for the treatment of endothelial dysfunction in patients with s
'/>"/>

SOURCE American Society of Hematology
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
2. New Data Highlighting Possible Impact of ESA Reimbursement Policies on Patient Care, Nations Blood Supply, to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting
3. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
4. University of Kansas Medical Center to Deploy Velos eResearch System-Wide
5. U.S. Naval Medical Research Center Resubmits IND Application for Proposed Op RESUS Clinical Trial in Trauma Patients in the Battlefield Setting
6. Dominos Pizza Pledges Support to the Fifth Annual St. Jude Childrens Research Hospital(R) Thanks and Giving(R) Campaign
7. Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects
8. Miami Jewish Home and Hospital, Berma Research Group and Segal Institute for Clinical Research Enrolling Local Patients in Study of Investigational Therapy to Treat Alzheimers Disease
9. Sarah Cannon Research Institute Selects OmniComm Systems Electronic Data Capture Solution, TrialMaster(TM), for Clinical Trials Management
10. Michael J. Fox Foundation Announces $11 Million in 2009 Funding for Translational, Pre-Clinical and Clinical Parkinsons Disease Research
11. SELECT TRIAL Used Selenomethionine Instead of High-Selenium Yeast, SelenoExcell(R) - Previous Research has Shown SelenoExcell(R) Supplementation to Reduce Lung, Colon and Prostate Cancers by as Much as 63%, Says Cypress Systems, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... N.J. , Aug. 28, 2015  IP Shakti, LLC, ... LLC. ... "Our new corporate identity signifies our transformation ... world,s first predictive analytics platform for patent claim validity." ... the launch of the proprietary AIA Shield™ platform, the Company ...
(Date:8/28/2015)... Denmark and ATLANTA , ... 2015 the US Food and Drug Administration (FDA) cleared the ... Disorder in adult patients who have failed to receive satisfactory ... is a non-invasive technique for stimulating neural tissue in the ... Depressive Disorder. The procedure has been proven safe and effective ...
(Date:8/28/2015)... August 28, 2015 The report "Eubiotics Market by ... Poultry, Ruminant, and Aquaculture), & by Region ( North ... Asia-Pacific , and Rest of the World) - Global ... market for Eubiotics was valued at USD 4.62 Billion in ... 2020, at a CAGR of 7.4% from 2015 to 2020. ...
Breaking Medicine Technology:IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 3Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5
... BARCELONA, Spain , June 1 Clinicians at Institut Catala ... in Spain using RapidArc® radiotherapy from Varian Medical Systems (NYSE: ... the first patient in the country to receive the fast and efficient ... "The treatment went ...
... BEIJING , June 1 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... it has received,the confirmation from the China International Tendering Company that Sinovac,was ... supply the Company,s hepatitis A vaccine, Healive, to the,Beijing Expanded Program of ... ...
Cached Medicine Technology:Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 2Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 3Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 4Sinovac Selected by Beijing CDC to Supply Hepatitis A Vaccine Healive(R) 2Sinovac Selected by Beijing CDC to Supply Hepatitis A Vaccine Healive(R) 3
(Date:8/29/2015)... ... August 29, 2015 , ... ... may extend and improve the lives of patients, according to a newly published ... here to read the full article. , The authors of the new ...
(Date:8/29/2015)... ... ... ProDrop Particles includes over 40 particle backdrops designed for use in ... users can shrink and stretch in the Final Cut Pro X timeline. Choose from ... scale, speed, range, and flare attributes with intuitive controls found in the top-right inspector ...
(Date:8/29/2015)... Houston, TX (PRWEB) , ... August 29, 2015 ... ... settlement allows the company to freely market and sell Arterosil and Arterosil HP, ... Daniels Health Sciences, LLC (DHS) sued Vascular Health Sciences, LLC (VHS) in the ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... No Malaria Day at the Zoo to celebrate children helping children, a thank ... their congregations throughout West Ohio have contributed to the United Methodist initiative to ...
(Date:8/28/2015)... ... 28, 2015 , ... For Dallas, the time is nearing for the annual ... Tenet Health. , The American Heart Association hosts their well-known Heart Walk to raise ... together, a difference can be made. Walkers can participate in the cause and someone ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2
... The American Lung Association in Iowa is happy to report ... Family Smoking Prevention and Tobacco Control Act (HR 1256) today. ... applauds Senators Tom Harkin and Chuck Grassley for playing instrumental roles ... the Family Smoking Prevention and Tobacco Control Act. This important legislation ...
... June 11 The Campaign for Tobacco-Free Kids applauds ... today to approve historic legislation that gives the U.S. ... products, including the authority to crack down on tobacco ... the bipartisan bill 79 to 17. The House has ...
... Kids applauds U.S. Senators Judd Gregg and Jeanne Shaheen for ... Food and Drug Administration (FDA) authority to regulate tobacco products, ... sales to kids. The U.S. Senate approved the bipartisan ... legislation, and Congress is expected to quickly send a final ...
... The Campaign for Tobacco-Free Kids applauds U.S. Senator Sherrod Brown ... historic legislation that gives the U.S. Food and Drug Administration ... crack down on tobacco marketing and sales to kids. ... 17. The House has approved similar legislation, and Congress ...
... , WASHINGTON, June 11 The Campaign for ... for voting today to approve historic legislation that gives the ... products, including the authority to crack down on tobacco marketing ... bipartisan bill 79 to 17. The House has approved ...
... June 11 Oclaro, Inc. (Nasdaq: OCLR ... has entered the eye-safe wavelength market with laser diode ... micrometer (um). The new long-wavelength devices target eye-safe applications ... , Eye-safe standards are important in environments where there ...
Cached Medicine News:Health News:Senators Harkin and Grassley Vote to Protect America's Kids from Tobacco 2Health News:Senators Harkin and Grassley Vote to Protect America's Kids from Tobacco 3Health News:Senators Gregg and Shaheen Vote to Protect America's Kids From Tobacco 2Health News:Senator Brown Leads Fight to Protect America's Kids from Tobacco 2Health News:Senators Murkowski and Begich Vote to Protect America's Kids from Tobacco 2Health News:Oclaro Launches Eye-Safe High Power Laser Diodes at LASER 2009 2Health News:Oclaro Launches Eye-Safe High Power Laser Diodes at LASER 2009 3
... a FAM-labeled probe that is designed to detect ... In addition, this ASR contains primers, a Texas ... sequence. This ASR requires an instrument that can ... as the Cepheid SmartCycler System. The Cepheid Analyte ...
... SpideRX Embolic Protection Device features the ability ... cross the lesion and a pre-loaded nitinol ... and recovery. Offering a fully rapid exchange ... use in the indicated applications:, Carotid Indication ...
Pefakit PiCT DxS Diluent for Determination of Total Heparin...
Controls for APC Resistance / Factor V Leiden Functional Assay...
Medicine Products: