Navigation Links
Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting
Date:12/6/2008

bset of patients (85 percent) had an overproduction of malignant cells mainly dependent on the late stages of blood cell differentiation, far downstream from the stem cell. In contrast, a second subset of patients (15 percent) had an early expansion of very immature malignant progenitor cells, close to the stem cell.

Researchers then hypothesized that the second subset of patients had a pre-existent molecular defect able to promote the early expansion of the malignant cells. With high-resolution arrays, researchers were able to identify one single gene, TET2, which belongs to a family of three genes of unknown function.

Researchers then further analyzed cells in five patients with TET2mutations, which demonstrated that TET2 defects target hematopoietic stem cells. Moreover, they show that in these five patients TET2 inactivation precedes the JAK2 V617Fmutation, suggesting that this new molecular lesion could be an early event in cancer stem cell formation.

To further test these findings, researchers sequenced TET2in 181 unselected JAK2 V617F patients with myeloproliferative disorders. TET2 mutations were found in 25 of the 181 patients, resulting in an overall 14 percent frequency.

Tetrahydrobiopterin (6R-BH4): Novel Therapy forEndothelial Dysfunction in Sickle Cell Disease

[LBA-5]

Lewis Hsu, M.D., Ph.D., Drexel University, Philadelphia, PA

*Abstract LBA-5 is being presented on Saturday, December 6, at 9:30 a.m. at the ASH press conference on advances in screening and treatment for sickle cell disease. The embargo for this abstract will break at that time.

The results of this phase II study showed that the investigational oral agent tetrahydrobiopterin is safe and well-tolerated. The drug
'/>"/>

SOURCE American Society of Hematology
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
2. New Data Highlighting Possible Impact of ESA Reimbursement Policies on Patient Care, Nations Blood Supply, to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting
3. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
4. University of Kansas Medical Center to Deploy Velos eResearch System-Wide
5. U.S. Naval Medical Research Center Resubmits IND Application for Proposed Op RESUS Clinical Trial in Trauma Patients in the Battlefield Setting
6. Dominos Pizza Pledges Support to the Fifth Annual St. Jude Childrens Research Hospital(R) Thanks and Giving(R) Campaign
7. Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects
8. Miami Jewish Home and Hospital, Berma Research Group and Segal Institute for Clinical Research Enrolling Local Patients in Study of Investigational Therapy to Treat Alzheimers Disease
9. Sarah Cannon Research Institute Selects OmniComm Systems Electronic Data Capture Solution, TrialMaster(TM), for Clinical Trials Management
10. Michael J. Fox Foundation Announces $11 Million in 2009 Funding for Translational, Pre-Clinical and Clinical Parkinsons Disease Research
11. SELECT TRIAL Used Selenomethionine Instead of High-Selenium Yeast, SelenoExcell(R) - Previous Research has Shown SelenoExcell(R) Supplementation to Reduce Lung, Colon and Prostate Cancers by as Much as 63%, Says Cypress Systems, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... VILLAGE, Nev. , July 28, 2014 PDL ... that the Company will release its second quarter 2014 financial ... August 11, 2014, after market close. PDL,s management will host ... Eastern Time to discuss the financial results.  A slide presentation ... link on the PDL website. Conference Call Details ...
(Date:7/28/2014)... 28, 2014  ProteinSimple announced today that it has ... new assay allows users to detect all proteins separated ... Western users can analyze proteins without the need for ... changed protein analysis as we know it today. First, the ... - no messy gels, no transfer tanks, no blots, ...
(Date:7/28/2014)... HILDEN , Germany and ... -- , Collaboration aims to ... plasma samples to guide the use of IRESSA  for ... test will build on QIAGEN,s FDA-approved  therascreen   EGFR test ... QIAsymphony family of automated instruments  Project enabled ...
Breaking Medicine Technology:PDL BioPharma to Announce Second Quarter 2014 Financial Results on August 11, 2014 2ProteinSimple Says "Never Run a Gel Again!" 2QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 2QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 3QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 4QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 5QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 6
... The non-profit Midwest Business Group on Health (MBGH) ... national organizations, have launched a health awareness campaign combining the ... people improve and manage health conditions. The Take Control ... will run through the end of the year and into ...
... NATICK, Mass., Oct. 28 Boston Scientific Corporation (NYSE: ... a definitive agreement under which Stryker Corporation will acquire ... billion, payable in cash, of which $1.4 billion is ... following the closing and upon the occurrence of the ...
Cached Medicine Technology:New 'Take Control of Your Health' Education Series to Improve Health of Chicagoans 2Boston Scientific Agrees to Sell Neurovascular Business to Stryker 2Boston Scientific Agrees to Sell Neurovascular Business to Stryker 3Boston Scientific Agrees to Sell Neurovascular Business to Stryker 4
(Date:7/28/2014)... (PRWEB) July 28, 2014 Irresistible infants have met ... Spoonful of Comfort. The online gifting company specializes in homemade chicken ... , The New Baby package starts with home-from-the-hospital essentials every new ... , 6 rolls , 6 cookies , ... , The soup is ready to heat and eat upon delivery, ...
(Date:7/28/2014)... July 28, 2014 According to a ... Solution Software Market- Global Industry Analysis, Size, Share, Growth, ... device market was valued at USD 3,005 million in ... of 13.8% from 2014 to 2020, to reach an ... Globally, the e-clinical solution software market is witnessing significant ...
(Date:7/28/2014)... Carolina State University is proposing a new theory to ... age, but don,t necessarily show declines in the workplace ... motivated older adults are to maintain focus on cognitive ... explain the difference we see in cognitive performance in ... psychology at NC State and author of a paper ...
(Date:7/28/2014)... Alta Resources , a global ... Fortune 500 brands, announced today that it plans to ... Wisconsin, California, Florida and the Philippines. More than 700 ... campus. , A majority of the hiring is to ... require additional staffing in preparation for the Annual Enrollment ...
(Date:7/28/2014)... July 28, 2014 Termed by the ... abuse causes more fatal overdoses than heroin and cocaine ... (1) Those who are particularly vulnerable to succumbing to ... up), with many in this age group taking at ... growing epidemic was reawakened in the White House in ...
Breaking Medicine News(10 mins):Health News:Spoonful of Comfort Announces "New Baby" Gift Package 2Health News:Global E-Clinical Solution Software Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Health News:Global E-Clinical Solution Software Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Health News:Global E-Clinical Solution Software Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Health News:Motivation explains disconnect between testing and real-life functioning for seniors 2Health News:Alta Resources to Fill Approximately 700 Positions in Brea 2Health News:Alta Resources to Fill Approximately 700 Positions in Brea 3Health News:Rx Drug Abuse Labeled Silent Killer: Claims Nearly 17,000 American Lives a Year; Novus Medical Detox Solution Involves Education and Governmental Support 2Health News:Rx Drug Abuse Labeled Silent Killer: Claims Nearly 17,000 American Lives a Year; Novus Medical Detox Solution Involves Education and Governmental Support 3Health News:Rx Drug Abuse Labeled Silent Killer: Claims Nearly 17,000 American Lives a Year; Novus Medical Detox Solution Involves Education and Governmental Support 4
... IRVINE, Calif., Nov. 3 Endologix, Inc. (Nasdaq: ELGX ), ... John McDermott, President and Chief Executive Officer, is scheduled to present ... at the Canaccord Adams 3rd Annual Cardiovascular Conference at the Nikko ... Event: Canaccord Adams 3rd Annual Cardiovascular ...
... the same holds true for humans, researchers say , TUESDAY, Nov. ... sweet life may also be the short life. , New research ... 20 percent of their life span. , It,s unclear what ... impact of diets high in sugar, according to the study authors, ...
... is also a prescription for self-esteem among breast cancer ... Medicine research. Breast cancer survivors who lift weights regularly ... more satisfied with their intimate relationships compared with survivors ... study published in the journal Breast Cancer Research ...
... ... in Jackson, Miss. has started posting surgical videos as part of a new section ... surgery to correct sunken chest syndrome in pediatric patients. As part the new portion ... unique procedure by way of video. , ...
... 3 Triple-S Management Corporation (NYSE: GTS ), the ... revenues of $507.3 million and operating income of $15.4 million ... of $18.1 million, or $0.62 per diluted share, includes an ... share, in net realized and unrealized gains on investments and ...
... claims and risk management provider Avizent announced today the introduction ... medical experts are involved in workers, compensation claims from day ... the new service is to safely return injured employees to ... workers, comp claims. Avizent is one of only a few ...
Cached Medicine News:Health News:Endologix to Present at Three Upcoming Conferences 2Health News:Sugar Shortens Life Span in Worms 2Health News:Weight training boosts breast cancer survivors' body image and intimate relationship satisfaction 2Health News:New Video Post Shows Minimally Invasive Procedure To Correct Sunken Chest Syndrome 2Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 2Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 3Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 4Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 5Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 6Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 7Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 8Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 9Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 10Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 11Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 12Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 13Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 14Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 15Health News:Triple-S Management Corporation Reports Third Quarter 2009 Results 16Health News:Avizent's New TeamCOMP Approach Helps Ensure Lower Workers' Comp Costs and Faster Claims Resolution 2
... two perforations which enable procedure-specific ... single or bilateral configurations to ... has two perforations which enable ... various single or bilateral configurations ...
Unique 2 in 1 design allows simultaneous absorption of excess fluid & protection of flap & hinge, Lint-free PVAmaterial....
Angled 45, 9mm from end, Longer design from bend to tip allows for easier placement of viscoelastic to all meridians, Dome shape, extra smooth tip...
Dome shape, extra smooth tip provides safe insertion through wound & manipulation within the eye. 45, 4.0mm from end...
Medicine Products: