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Laser Burn Injuries in One Eye Can Disrupt Protective Immune Privilege in Both Eyes, Study Finds
Date:2/26/2009

defense.

They found that immune privilege was disrupted in both eyes after six hours and continued to be disrupted even after 56 days.

When they injected the same antigen into the eyes of a group of control mice without burns, they observed no inflammation.

Since created in the 1960s, lasers have found their way onto the battlefield, into the operating rooms and into modern research laboratories. While ophthalmologists have been aware of the local damage done by laser burns to retinas, they have not been tuned into the possibility of long-term loss of immune privilege in one or both eyes.

Understanding mechanisms that destroy or disrupt immune privilege will ultimately lead to novel therapies to restore that special privilege not only in the eye but in the brain and the reproductive system as well, she adds.

The next steps for the team will be to study the novel mechanisms that allow for communication between the injured and non-injured eye.

Other scientists involved in the study include: First author, Hong Qiao, MD, PhD, and second author Kenyatta Lucas, PhD, both scientists at Schepens.

Schepens Eye Research Institute is an affiliate of Harvard Medical School and the largest independent eye research institute in the nation.


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SOURCE Schepens Eye Research Institute
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